The Efficacy of Dextrose Prolotherapy for Temporomandibular Joint Hypermobility: A Preliminary Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Refai, Hamida; Altahhan, Obada; Elsharkawy, Rehab

doi:10.1016/j.joms.2011.02.128

Cited by 60 publications

(84 citation statements)

References 15 publications

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“…Recently, prolotherapy with 10% dextrose was demonstrated successful in reducing pressure-induced pain at the TMJ in the hypermobile subject [159]; with caution, its use may be considered in other joints also.…”

Section: Principles Of Managementmentioning

confidence: 99%

Ehlers-Danlos Syndrome, Hypermobility Type: An Underdiagnosed Hereditary Connective Tissue Disorder with Mucocutaneous, Articular, and Systemic Manifestations

Castori¹

2012

ISRN Dermatology

176

239

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Ehlers-Danlos syndrome, hypermobility type, constituting a phenotypic continuum with or, perhaps, corresponding to the joint hypermobility syndrome (JHS/EDS-HT), is likely the most common, though the least recognized, heritable connective tissue disorder. Known for decades as a hereditary condition with predominant rheumatologic manifestations, it is now emerging as a multisystemic disorder with widespread manifestations. Nevertheless, the practitioners' awareness of this condition is generally poor and most patients await years or, perhaps, decades before reaching the correct diagnosis. Among the various sites of disease manifestations, skin and mucosae represent a neglected organ where the dermatologist can easily spot diagnostic clues, which consistently integrate joint hypermobility and other orthopedic/neurologic manifestations at physical examination. In this paper, actual knowledge on JHS/EDS-HT is summarized in various sections. Particular attention has been posed on overlooked manifestations, including cutaneous, mucosal, and oropharyngeal features, and early diagnosis techniques, as a major point of interest for the practicing dermatologist. Actual research progresses on JH/EDS-HT envisage an unexpected link between heritable dysfunctions of the connective tissue and a wide range of functional somatic syndromes, most of them commonly diagnosed in the office of various specialists, comprising dermatologists.

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Section: Principles Of Managementmentioning

confidence: 99%

Ehlers-Danlos Syndrome, Hypermobility Type: An Underdiagnosed Hereditary Connective Tissue Disorder with Mucocutaneous, Articular, and Systemic Manifestations

Castori¹

2012

ISRN Dermatology

176

239

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“…26,30,46,60 Additional treatments repeat this process, allowing a gradual build-up of tissue to restore the original strength of the area. Studies report that prolotherapy is helpful in treating tendinopathies and ligament sprains, 12,38,39,44,72 joint instabilities, 20,25,32,62,68,75,83 osteoarthritis, [57][58][59]61 and chronic musculoskeletal pain and low back pain when coupled with spinal manipulation or corticosteroid injections. 23,56 However, studies on the effectiveness of prolotherapy for foot and ankle injuries are limited, and blinded studies are lacking.…”

Section: Case Description Historymentioning

confidence: 99%

Conservative Management of Second Metatarsophalangeal Joint Instability in a Professional Dancer: A Case Report

Ojofeitimi¹,

Bronner²,

Becica³

2016

J Orthop Sports Phys Ther

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“…11 At the inception of the present study, the efficacy of DPT for TMD had been reported in 1 small (n¼12) randomized trial by using a method targeting both intra-articular and extraarticular sites. 12 Intra-articulareonly injection of the temporomandibular joint (TMJ) for TMD has been recommended for reproducibility and simplicity and is commonly used. 13 We tested the hypothesis that DPT using an intra-articulareonly protocol will result in significant improvement in TMD pain and dysfunction and increase maximal interincisal opening (MIO).…”

mentioning

confidence: 99%

Treatment of Temporomandibular Dysfunction With Hypertonic Dextrose Injection (Prolotherapy): A Randomized Controlled Trial With Long-term Partial Crossover

Louw

Reeves²,

Lam

et al. 2019

Mayo Clinic Proceedings

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Objective: To assess the efficacy and longer-term effectiveness of dextrose prolotherapy injections in participants with temporomandibular dysfunction. Patients and Methods: A randomized controlled trial with masked allocation was conducted from January 14, 2013, through December 19, 2015. Forty-two participants (with 54 joints) meeting temporomandibular dysfunction criteria were randomized (1:1) to 3 monthly intra-articular injections (20% dextrose/0.2% lidocaine or 0.2% lidocaine) followed by as-needed dextrose/0.2% lidocaine injections through 1 year. Primary and secondary outcome measures included a 0 to 10 Numerical Rating Scale score for facial pain and jaw dysfunction; maximal interincisal opening (MIO) measured in millimeters, percentage of joints with 50% or more change (improvement) in pain and function, and satisfaction.

show abstract

The Efficacy of Dextrose Prolotherapy for Temporomandibular Joint Hypermobility: A Preliminary Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Cited by 60 publications

References 15 publications

Ehlers-Danlos Syndrome, Hypermobility Type: An Underdiagnosed Hereditary Connective Tissue Disorder with Mucocutaneous, Articular, and Systemic Manifestations

Ehlers-Danlos Syndrome, Hypermobility Type: An Underdiagnosed Hereditary Connective Tissue Disorder with Mucocutaneous, Articular, and Systemic Manifestations

Conservative Management of Second Metatarsophalangeal Joint Instability in a Professional Dancer: A Case Report

Treatment of Temporomandibular Dysfunction With Hypertonic Dextrose Injection (Prolotherapy): A Randomized Controlled Trial With Long-term Partial Crossover

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