The efficacy of EGb 761 in patients with senile dementia of the alzheimer type, a double‐blind, placebo‐controlled study on different levels of investigation

Hofferberth, B.

doi:10.1002/hup.470090308

Cited by 127 publications

(99 citation statements)

References 10 publications

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“…Improvement was significantly higher in the ginkgo treatment group. Similar improvement in cognitive performance has been demonstrated in other doubleblind placebo controlled studies (Rai 1991;Hofferberth 1994).…”

Section: Carotenoids (Eg Vitamin A)supporting

confidence: 85%

The ‘Natural Health Service’: natural does not mean safe

Dunne¹

2009

Adv. psychiatr. treat

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SummaryPlants have been used for medicinal purposes for centuries, treating everything from non-specific ailments such as backache and colds to serious conditions, including depression and cancer. In this review, a few commonly known plants with psychotropic effects (St John's wort, Ginkgo biloba, kava, ginseng and valerian) are discussed by way of illustration. The readers' attention is brought to important interactions between herbal remedies and conventional drugs. A background to the constituents of herbs, possible mechanisms of action and an explanation of their antioxidant properties is given.

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Section: Carotenoids (Eg Vitamin A)supporting

confidence: 85%

The ‘Natural Health Service’: natural does not mean safe

Dunne¹

2009

Adv. psychiatr. treat

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“…Numerous trials have found small but significant beneficial effects of EGb (120 to 240 mg/d) on memory and social function in early dementia. [31][32][33][34] Potential bleeding complications of EGb are a concern since this population is also at increased risk for ICH because of coexisting hypertension and cerebral amyloid angiopathy. A recent case report described bilateral hematoma formation presumably due to EGb.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Antioxidant Therapies in Transient Focal Ischemia in Mice

Clark

Rinker

Lessov

et al. 2001

Stroke

128

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Background and Purpose-Ginkgo biloba extract (EGb) and ␣-lipoic acid (LA) are commercially available "antioxidant supplements" with a variety of actions that may be beneficial during acute stroke. These actions include inhibiting platelet and leukocyte activation and adhesion, reducing free radical generation, and increasing cerebral blood flow. Both EGb and LA have been shown to be neuroprotective in cell culture and global central nervous system ischemia models. In this study we investigated the neuroprotective efficacy of EGb and LA in a clinically relevant, transient focal central nervous system ischemic model. Methods-In the EGb study, 60 adult C57blk mice were randomized to treatment with EGb given orally (via gavage) for 7 days: low dose, 50 EGb mg/kg daily; high dose, 100 mg/kg daily; matched placebo. On day 7, reversible middle cerebral artery occlusion was produced by advancing a silicone-coated 8-0 filament into the internal carotid artery for 45 minutes followed by reperfusion. At 24 hours, the animals were evaluated on a 28-point clinical scale, and infarct volume was determined with the use of triphenyltetrazolium chloride. In the LA study, 24 C57blk mice were treated with 100 mg/kg SC of LA or placebo 1.5 hours before transient MCAO, as in the EGb study.

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“…One study involving 40 patients investigated the efficacy of ginkgo in Alzheimer's disease at 1, 2 and 3 months (Hofferberth, 1994). Table 1 illustrates the results from the primary outcome measure, the SKT and the Sandoz Clinical Assessment Geriatric Scale (SCAG), which rated psychopathological changes (Shader et al, 1974).…”

Section: Clinical Studiesmentioning

confidence: 99%

The use of ginkgo biloba in the treatment of dementia

Maidment

2001

Psychiatr. bull.

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Aims and MethodTo assess and update the available data on use of ginkgo to treat dementia. A Medline search as conducted for the period January 1985 to October 2000. The search included other aspects of the usage of ginkgo, such as side-effects, mechanism of action and drug interactions.ResultsMost of the trials using ginkgo were to treat cerebral insufficiency. Only five trials could be identified that used ginkgo to treat dementia. There are no trials comparing ginkgo to cholinesterase inhibitors such as donepezil.Clinical ImplicationsGinkgo is generally well-tolerated and appears to ease the symptoms of dementia. Although it has been suggested that the effect is comparable to donepezil, confirmation from controlled studies is required.

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The efficacy of EGb 761 in patients with senile dementia of the alzheimer type, a double‐blind, placebo‐controlled study on different levels of investigation

Cited by 127 publications

References 10 publications

The ‘Natural Health Service’: natural does not mean safe

The ‘Natural Health Service’: natural does not mean safe

Efficacy of Antioxidant Therapies in Transient Focal Ischemia in Mice

The use of ginkgo biloba in the treatment of dementia

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