The efficacy of Ginkgo special extract EGb 761 in patients with tinnitus

Morgenstern, C.; Biermann, Elmar

doi:10.5414/cpp40188

Cited by 57 publications

(38 citation statements)

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“…There is a growing body of evidence, ranging from in vitro experiments to pathological analyses and epidemiological studies, which indicates the beneficial role of GbE in the treatment of cardiovascular disease (35,36); however, its clinical use is still underrepresented because of the lack of knowledge about its cellular and molecular mechanisms of action (60). The aim of the present study was to elucidate the underlying mechanism by which GbE protects against oxLDL-induced endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 97%

Ginkgo bilobaextract attenuates oxLDL-induced oxidative functional damages in endothelial cells

Ou¹,

Lee²,

Lee³

et al. 2009

Journal of Applied Physiology

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Section: Discussionmentioning

confidence: 97%

Ginkgo bilobaextract attenuates oxLDL-induced oxidative functional damages in endothelial cells

Ou¹,

Lee²,

Lee³

et al. 2009

Journal of Applied Physiology

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“…The indication for the use of Ginkgo extract that is best documented by clinical trials is dementia of various origins [13]. A second field of application for Ginkgo biloba is represented by diseases that are connected to dysregulation of vascular tone and endothelial dysfunction, such as intermittent claudication [14], Raynaud's disease [15], or tinnitus [16]. Despite its growing popularity and the increasing number of studies communicating a beneficial role of Ginkgo biloba extract in the treatment of cardiovascular diseases [14][15][16], its clinical use is still underrepresented due to the lack of knowledge about its cellular and molecular mechanisms of action [17].…”

Section: Discussionmentioning

confidence: 99%

Ginkgo biloba extract EGb® 761 increases endothelial nitric oxide production in vitro and in vivo

Koltermann

Hartkorn

Koch

et al. 2007

Cell. Mol. Life Sci.

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Beneficial effects of Ginkgo biloba on peripheral arterial occlusive disease have been repeatedly shown in clinical trials, especially after use of EGb 761, a standardized special extract. Since the underlying mechanisms are widely unknown, we aimed to elucidate the molecular basis on which EGb 761 protects against endothelial dysfunction in vitro and in vivo. Application of therapeutically feasible doses of EGb 761 for 48 h caused endothelial nitric oxide (NO) production by increasing endothelial nitric oxide synthase (eNOS) promoter activity and eNOS expression in vitro. Phosphorylation of eNOS at a site typical for Akt (Ser 1177) was acutely enhanced by treatment with EGb 761, as was Akt phosphorylation at Ser 478. Furthermore, the extract caused acute relaxation of isolated aortic rings and NO-dependent reduction of blood pressure in vivo in rats. These influences on eNOS represent a putative molecular basis for the protective cardiovascular properties of EGb 761.

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“…De acordo com os resultados dos ensaios clínicos randomizados, duplos-cegos e controlados, esses medicamentos são efi cazes no tratamento da claudicação intermitente (Pittler & Ernst, 2000;Jacoby& Mohler, 2004) e da insufi ciência cerebral (doença caracterizada por sintomas típicos, tais como difi culdades de concentração e memória, confusão, indisposição, cansaço, redução da performance física, ansiedade, tontura, zumbido e cefaléia) (Gerhardt et al, 1990;Kleijnen & Knipschild, 1992;Hopfenmüller, 1994), podendo constituir uma alternativa terapêutica para o tratamento de demências do tipo Alzheimer e multi-infarto (Oken et al, 1998;Rogers et al, 1998;Wettstein, 2000;Le Bars et al, 2002;Schulz, 2003) e do zumbido (Ernst & Stevinson, 1999;Drew & Davies, 2001;Morgenstern & Biermann, 2002;Rejali et al, 2004;Smith et al, 2005). Os constituintes químicos considerados ativos do ginkgo são os fl avonóides (glicosídeos de quercetina, canferol e isoramnetina) e as lactonas terpênicas (ginkgolídeos e bilobalídeo) (DeFeudis, 1998).…”

Section: Ginkgounclassified

Interações entre fármacos e medicamentos fitoterápicos à base de ginkgo ou ginseng

Alexandre¹,

Bagatini²,

Simões³

2008

Rev. bras. farmacogn.

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RESUMO:Os medicamentos fi toterápicos são amplamente utilizados, principalmente, pelos portadores de doenças crônicas e em associações medicamentosas com diversos fármacos. As possíveis interações entre eles estão sendo muito estudadas, pois podem alterar os perfi s de efi cácia e segurança de muitos fármacos. Nesta revisão, as informações foram localizadas, avaliadas e sistematizadas e contêm as principais interações entre fármacos e medicamentos fi toterápicos elaborados com ginkgo ou ginseng. Verifi cou-se que os medicamentos fi toterápicos elaborados com tais plantas podem interferir na farmacocinética e/ou farmacodinâmica de diversos fármacos, podendo provocar conseqüências graves aos pacientes. O ginkgo pode interferir com anticoagulantes orais, antiplaquetários e com fármacos metabolizados pelo sistema P450-CYP3A4. O ginseng pode interagir com antidepressivos inibidores da monoamino oxidase, anticoagulantes orais, anti-hipertensivos, e contraceptivos à base de estrogênios. Além disso, não é recomendada a administração concomitante de ginkgo ou ginseng com antineoplásicos. Nesse sentido, o uso concomitante de medicamentos fi toterápicos à base de ginkgo ou ginseng com outros fármacos deve ser adequadamente monitorado. Unitermos: Ginkgo biloba, Panax ginseng, ginkgo, ginseng, interações medicamentosas.ABSTRACT: "Interactions between drugs and ginkgo or ginseng herbal medicines". Herbal medicines are widely used especially by patients with chronic diseases, often administered concomitantly with synthetic drugs, raising the potential of pharmacokinetic and pharmacodynamic drug-herb interactions. From the last years, there is an increasing interest in this subject refl ected by the great number of documented case reports, in vivo studies, and also clinical trials evaluating drug-herb interactions. The aim of this paper was to review the literature in order to identify reported interactions between ginkgo or ginseng herbal medicines and drugs as well as to evaluate and summarize these information. Interactions between ginkgo or ginseng herbal medicines and drugs can occur and may lead to serious consequences. Ginkgo has the potential to cause signifi cant interactions with anticoagulant and antiplatelet drugs, and also with drugs metabolized by the cytochrome P450 enzyme system, especially by CYP3A4. Ginseng has the potential to cause signifi cant interactions with monoamine oxidase inhibitors, warfarin, antihypertensive agents and estrogens. Additionally, both should be avoided with anticancer drugs. Based on these data and regarding patient's safety, the concomitant use of herbal medicines and drugs has to be properly surveyed by physicians and/or other health care professionals.Keywords: Ginkgo biloba, Panax ginseng, ginkgo, ginseng, drug-herb interactions. INTRODUÇÃOA utilização de plantas medicinais e medicamentos fi toterápicos para a recuperação da saúde é uma prática generalizada, sendo o resultado do acúmulo secular de conhecimentos empíricos sobre a ação dos vegetais por diversos grupos étnicos (Simõe...

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The efficacy of Ginkgo special extract EGb 761 in patients with tinnitus

Cited by 57 publications

References 0 publications

Ginkgo bilobaextract attenuates oxLDL-induced oxidative functional damages in endothelial cells

Ginkgo bilobaextract attenuates oxLDL-induced oxidative functional damages in endothelial cells

Ginkgo biloba extract EGb® 761 increases endothelial nitric oxide production in vitro and in vivo

Interações entre fármacos e medicamentos fitoterápicos à base de ginkgo ou ginseng

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