The Efficacy of Glucosamine and Chondroitin Sulfate in the Treatment of Osteoarthritis: Are These Saccharides Drugs or Nutraceuticals?

Šimánek,; Křen,; Ulrichová, Jitka; Gallo, Jiří

doi:10.5507/bp.2005.004

Cited by 29 publications

(25 citation statements)

References 39 publications

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“…ХС и глюкозамин с позиций доказательной медицины среди хондропротекторных средств имеют высшую сте-пень доказательности и достоверности результатов -категорию А, в связи с чем на их основе сегодня и произ-водят большинство хондропротекторов, применяющихся в мировой практике [23][24][25][26][27][28]. Поэтому применение глюко-замина и хондроитина сульфата является патогенетиче-ски обоснованным.…”

Section: ключевые слова: дорсалгия спондилоартроз структурно-модифициunclassified

“…Этот метаболит содержится в сыворотке крови, в органах и тканях (боль-ше всего -в почках), в суставном хряще и участвует в биосинтезе гликозаминогликанов. В экспериментальных исследованиях доказано, что глюкозамин стимулирует синтез протеогликанов, ингибирует деградацию протео-гликанов и стимулирует регенерацию хряща после экс-периментально вызванного повреждения [45][46][47][48]. Глюкозамина сульфат входит в состав матрикса хрящевой ткани, участвует в синтезе клеточной мембраны, коллаге-на и костного матрикса, а также в синтезе гликолипидов, гликопротеинов, гликозаминогликанов, суставных протео-гликанов, муцина и гиалуроновой кислоты.…”

Section: препараты структурно модифицирующие хрящ обладают обезболиunclassified

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The place of chondroprotectors in the treatment of osteoarthritis of the spine

Пизова¹

2016

Med. sov.

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Section: ключевые слова: дорсалгия спондилоартроз структурно-модифициunclassified

Section: препараты структурно модифицирующие хрящ обладают обезболиunclassified

The place of chondroprotectors in the treatment of osteoarthritis of the spine

Пизова¹

2016

Med. sov.

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“…Glucosamine and chondroitin promote the biosynthesis of proteoglycan and inhibit the degradative enzymes which are responsible for the premature breakdown of cartilage in OA [29,30]. Clinical studies conducted on glucosamine in the treatment of OA Efficacy of glucosamine in the treatment of OA was reported in earlier clinical trials provided by Rottapharm [31].…”

Section: Modes Of Action Of Glucosamine and Chondroitin In Oamentioning

confidence: 99%

Nutraceutical Formulations Containing Glucosamine and Chondroitin Sulphate in the Treatment of Osteoarthritis: Emphasis on Clinical Efficacy and Formulation Challenges

Agiba¹

2017

Int J Curr Pharm Sci

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Osteoarthritis (OA) is essentially a debilitating disease symptomatized by a gradual loss of articular joint cartilage, causing painful impairment among the population of different ages, particularly patients over the age of 50 y. Nutraceuticals; namely glucosamine and chondroitin have been widely used in the treatment of OA. The chondroprotective properties of the aforementioned agents have been reported, allowing the repair and recovery of the articular surface in OA. The purpose of this review article is to report the current evidence for the use of glucosamine and chondroitin sulphate in the treatment of knee OA with emphasis on their indications for clinical use, effectiveness and safety. It also highlights the role of some advanced formulation technologies in optimizing the delivery of those drugs.

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“…32 Both compounds are synthesized naturally in each joint. 29 The exact mechanism of action of chondroitin sulphate 32 and glucosamine sulphate 24,32 , in the treatment of osteoarthritis, has not been fully elucidated. These substances act synergistically to stimulate glycosaminoglycan synthesis in chondrocytes.…”

Section: E3mentioning

confidence: 99%

“…A daily dose of 1,500 mg, 19,29 divided into three doses (500 mg each) is the protocol of choice in cases of osteoarthritis/osteoarthrosis. Though the recommended dose for long-term use of chondroitin sulphate is 800 29 to 1,200 mg/day, 19 also divided into fractional doses, and associations between the two substances are well tolerated by patients.…”

Section: E4mentioning

confidence: 99%

Use of chondroitin sulphate and glucosamine sulphate in degenerative changes in TMJ: a systematic review

Machado¹,

Machado²,

Cunali

2012

Dental Press J. Orthod.

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Introduction: Degenerative changes in Temporomandibular Joint (TMJ) have increased in prevalence and severity over the years. Within this context, it's necessary to obtain safe and effective therapies for control and management of the patient in cases of osteoarthritis and osteoarthrosis of the TMJ. Therapeutic options range from intra-articular infiltration protocols, occlusal splints, pharmacological therapies and physiotherapy and educational measures. The alternative treatment with structure-modifying agents, like as chondroitin and glucosamine sulphates, showed promising results, and especially safety. Thus, through a systematic literature review, this study aimed to analyze and discuss effectiveness and safety of chondroitin and glucosamine in degenerative changes of the TMJ.Methods: Survey in research bases MEDLINE, Cochrane, EMBASE, Pubmed, Lilacs and BBO, between the years of 1966 and January 2009, with focus in randomized clinical trial (RCTs) and quasi-randomized clinical trials, systematic reviews and meta-analysis. Results:After application of the inclusion criteria 2 articles were selected, both randomized controlled double-blind clinical trials, which evaluated the effectiveness of chondroitin and glucosamine in degenerative changes of the TMJ. Conclusions:There is the necessity of further RCT, with representative samples and long follow-up time, to obtainment more precise cause-effect relationships and to achieve an effective and objective protocol involving chondroitin and glucosamine in cases of degenerative changes of the TMJ. Introdução: as alterações degenerativas da Articulação Temporomandibular (ATM) têm aumentado em prevalência e em severidade ao longo dos anos. Dentro desse contexto, surge a necessidade de se obter terapêuticas efetivas e seguras para o controle e o manejo do paciente em situações de osteoartrite e osteoartrose da ATM. As opções terapêuticas variam desde protocolos de infiltrações articulares, dispositivos interoclusais, terapias farmacológicas e medidas fisioterápicas e educacionais. A alternativa de tratamento com agentes modificadores de estrutura -tais como o sulfato de condroitina e o sulfato de glicosamina -apresenta resultados promissores e, principalmente, seguros. KeywordsObjetivo: através de uma revisão sistemática da literatura, este trabalho teve como objetivo analisar e discutir a efetividade e a segurança da condroitina e da glicosamina nas alterações degenerativas da ATM.Métodos: levantamento nas bases de dados MEDLINE, Cochrane, Embase, PubMed, LILACS e BBO, no período compreendido entre 1966 e 2009, com enfoque em estudos clínicos randomizados (RCTs) e quase-randomizados, revisões sistemáticas e meta-análises.Resultados: após a aplicação dos critérios de inclusão, chegou-se a dois artigos (estudos clínicos randomizados controlados e duplo-cegos), que avaliaram a efetividade da condroitina e da glicosamina nas alterações degenerativas da ATM.Conclusão: existe a necessidade da realização de novos RCTs -com amostras representativas e tempo de acompanhament...

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The Efficacy of Glucosamine and Chondroitin Sulfate in the Treatment of Osteoarthritis: Are These Saccharides Drugs or Nutraceuticals?

Cited by 29 publications

References 39 publications

The place of chondroprotectors in the treatment of osteoarthritis of the spine

The place of chondroprotectors in the treatment of osteoarthritis of the spine

Nutraceutical Formulations Containing Glucosamine and Chondroitin Sulphate in the Treatment of Osteoarthritis: Emphasis on Clinical Efficacy and Formulation Challenges

Use of chondroitin sulphate and glucosamine sulphate in degenerative changes in TMJ: a systematic review

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