The efficacy of human papillomavirus prophylactic vaccination after conization in preventing cervical intraepithelial neoplasia recurrence: A prospective observational study in China

Chen, Ming; Li, Cheng; Cui, Qiulin; Cheng-li, Zhou; Chen, Peisong; Yao, Shuzhong

doi:10.1016/j.ejogrb.2023.04.014

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…Chen et al's prospective cohort study, with a 2-year follow-up, investigated the vaccine's influence on CIN2+ recurrence [15]. The analysis, which included HPV testing at 6 months, 1 year, and 2 years, defined recurrence through histologically confirmed CIN2+.…”

Section: Discussionmentioning

confidence: 99%

“…Emerging research suggests that the HPV vaccine has the potential to prevent recurrence of high-grade cervical dysplasia post-conization [15][16][17][18], and yet there is a lack of consensus or national guidelines endorsing post-treatment HPV vaccination for CIN2+ [19]. Consequently, the decision to recommend vaccination post-conization is left to individual gynecologists, which, combined with out-of-pocket costs [14], leads to disparities in vaccine uptake among treated women.…”

Section: Introductionmentioning

confidence: 99%

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Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022

Rykkelid,

Wennberg,

Richardsen

et al. 2024

Pathogens

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Human papillomavirus (HPV) is associated with cellular changes in the cervix leading to cancer, which highlights the importance of vaccination in preventing HPV infections and subsequent cellular changes. Women undergoing the loop electrosurgical excision procedure (LEEP), a treatment for high-grade cervical intraepithelial neoplasia (CIN2+), remain at risk of recurrence. This study assessed the effect of post-conization HPV vaccination on the viral status of women at six months post-conization, aiming to evaluate the vaccine’s effectiveness in preventing recurrence of CIN2+. A retrospective cohort study was conducted among women in Troms and Finnmark who underwent conization in 2022. Using the SymPathy database and the national vaccination register (SYSVAK), we analyzed the vaccination statuses and HPV test results of women born before 1991, who had not received the HPV vaccine prior to conization. Out of 419 women undergoing conization, 243 met the inclusion criteria. A significant association was found between post-conization HPV vaccination and a negative HPV test at six months of follow-up (ARR = 12.1%, p = 0.039). Post-conization HPV vaccination significantly reduced the risk of a positive HPV test at the first follow-up, suggesting its potential in preventing the recurrence of high-grade cellular changes. However, the retrospective design and the insufficient control of confounding variables in this study underscore the need for further studies to confirm these findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022

Rykkelid,

Wennberg,

Richardsen

et al. 2024

Pathogens

View full text Add to dashboard Cite

show abstract

“…Emerging research suggests the HPV vaccine has potential to prevent recurrence of high-grade cervical dysplasia post-conization [15][16][17][18], yet there is a lack of consensus or national guidelines endorsing post-treatment HPV vaccination for CIN2+ [19]. Consequently, the decision to recommend vaccination post-conization is left to individual gynecologists, which combined with out-of-pocket costs [14], leads to disparities in vaccine uptake among treated women.…”

Section: Introductionmentioning

confidence: 99%

Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022

Rykkelid,

Wennberg,

Richardsen

et al. 2024

Preprint

View full text Add to dashboard Cite

Human papillomavirus (HPV) is associated with cellular changes of the cervix leading to cancer, which highlights the importance of vaccination in preventing HPV infections and subsequent cellular changes. Women undergoing treatment (LEEP) for high-grade cervical intraepithelial neoplasia (CIN2+) remain at risk for recurrence. This study assesses the effect of post-conization HPV vaccination on the viral status of women six months post-conization, aiming to evaluate the vaccine's effectiveness in preventing recurrence of CIN2+. A retrospective cohort study was conducted among women in Troms and Finnmark who underwent conization in 2022. Using the SymPathy database and the national vaccination register (SYSVAK), we analyzed the vaccination status and HPV test results of women born before 1991, who had not received the HPV vaccine prior to conization. Out of 419 women undergoing conization, 243 met the inclusion criteria. A significant association was found between post-conization HPV vaccination and a negative HPV test at six months follow-up (ARR = 12.1%, P = 0.039). Post-conization HPV vaccination significantly reduced the risk of a positive HPV test at the first follow-up, suggesting its potential in preventing recurrence of high-grade cellular changes. The retrospective design and the insufficient control of confounding variables underscore the necessity for further studies to confirm these findings.

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Effect of 5-aminolevulinic acid photodynamic therapy versus loop electrosurgical excision procedure for cervical intraepithelial neoplasia grade 2 treatment

Cai,

Yang,

Ding

et al. 2024

Photodiagnosis and Photodynamic Therapy

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The efficacy of human papillomavirus prophylactic vaccination after conization in preventing cervical intraepithelial neoplasia recurrence: A prospective observational study in China

Cited by 7 publications

References 31 publications

Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022

Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022

Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022

Effect of 5-aminolevulinic acid photodynamic therapy versus loop electrosurgical excision procedure for cervical intraepithelial neoplasia grade 2 treatment

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