2020
DOI: 10.1186/s13019-020-01098-y
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The efficacy of hydrogel foams in talc Pleurodesis

Abstract: Background: Malignant pleural effusions are a serious complication of many late stage cancers that adversely affect quality of life. Pleurodesis with talc slurry is a standard treatment option, but clinical failures occur, possible due to poor talc delivery. A novel drug-delivery system was developed that fills the entire thoracic cavity with a liquid foam containing talc. The foam is designed to gel and adhere to the tissue walls at body temperature, to improve talc deposition and efficacy. Methods: Rheology,… Show more

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Cited by 3 publications
(1 citation statement)
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“…Hydrogel foams are very attractive for biomedical [ 1 , 2 , 3 , 4 , 5 ], cosmetic [ 6 ], food [ 7 ], and agricultural applications [ 8 ] thanks to their absorption capacity, low density, large surface-to-volume ratio, biocompatibility, and mechanical properties. Since they are obtained by the gelling of an initially liquid foam via a method called “liquid foam templating” [ 9 , 10 , 11 ], a reliable foam generation process requires the fine-tuning of a wide range of interrelated timescales: foaming time, gelation time, and foam ageing time.…”
Section: Introductionmentioning
confidence: 99%
“…Hydrogel foams are very attractive for biomedical [ 1 , 2 , 3 , 4 , 5 ], cosmetic [ 6 ], food [ 7 ], and agricultural applications [ 8 ] thanks to their absorption capacity, low density, large surface-to-volume ratio, biocompatibility, and mechanical properties. Since they are obtained by the gelling of an initially liquid foam via a method called “liquid foam templating” [ 9 , 10 , 11 ], a reliable foam generation process requires the fine-tuning of a wide range of interrelated timescales: foaming time, gelation time, and foam ageing time.…”
Section: Introductionmentioning
confidence: 99%