The Efficacy of Hyperbaric Oxygen Therapy in Improving the Quality of Life in Patients With Problem Wounds

Lin, Li‐Chen; Yau, Grace; Lin, Ting-Li; Lin, Tsung-Kun; Tang, Yuying; Wang, Kwua-Yun

doi:10.1097/01.jnr.0000387580.97092.95

Cited by 16 publications

(8 citation statements)

References 16 publications

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“…Another microsphere system using PLGA and H 2 O 2 /poly(2-vinlypyrridione) liberated approximately 150 mmHg P O2 into a sealed container over several days [52]. Clinical hyperbaric oxygen therapy maintains oxygen pressure at 2.5 times that of atmospheric oxygen for 30 to 120 min, and systemic oxygen levels in the patient are elevated afterward for some time [53]. This exposure must be closely administered since hyperbaric oxygen therapy can lead to complications such as ruptured ear drums, sinus and lung damage, vision changes, and most seriously, oxygen poisoning, which can permanently damage the lungs and the central nervous system [54].…”

Section: Discussionmentioning

confidence: 99%

Fluorinated methacrylamide chitosan hydrogels enhance collagen synthesis in wound healing through increased oxygen availability

et al. 2016

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In this study, methacrylamide chitosan modified with perfluorocarbon chains (MACF) is used as the base material to construct hydrogel dressings for treating dermal wounds. MACF hydrogels saturated with oxygen (+ O2) are examined for their ability to deliver and sustain oxygen, degrade in a biological environment, and promote wound healing in an animal model. The emerging technique of metabolomics is used to understand how MACF + O2 hydrogel dressings improve wound healing. Results indicate that MACF treatment facilitates oxygen transport rate that is two orders of magnitude greater than base MAC hydrogels. MACF hydrogel dressings are next tested in an in vivo splinted rat excisional wound healing model. Histological analysis reveals that MACF + O2 dressings improve re-epithelialization (p < 0.0001) and synthesis of collagen over controls (p < 0.01). Analysis of endogenous metabolites in the wounds using global metabolomics demonstrates that MACF + O2 dressings promotes a regenerative metabolic process directed toward hydroxyproline and collagen synthesis, with confirmation of metabolite levels within this pathway. The results of this study confirm that increased oxygen delivery through the application of MACF + O2 hydrogels enhances wound healing and metabolomics analyses provides a powerful tool to assess wound healing physiology.

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Section: Discussionmentioning

confidence: 99%

Fluorinated methacrylamide chitosan hydrogels enhance collagen synthesis in wound healing through increased oxygen availability

et al. 2016

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“…in 15 patients with foot ulcers (11 patients with diabetes), overall health related quality of life improved after hyperbaric oxygen therapy. This improvement was linked to self‐perceived wound severity [24].…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen therapy improves health‐related quality of life in patients with diabetes and chronic foot ulcer

2011

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“…Overall quality of life improved after HBO therapy in a small study by Lin et al [40] evaluating HRQOL in 15 patients with foot ulcers (11 diabetic patients). HRQOL has also been evaluated in two double-blinded RCTs.…”

Section: Quality Of Lifementioning

confidence: 98%

What is the Role of Hyperbaric Oxygen in the Management of Diabetic Foot Disease?

2011

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Systemic hyperbaric oxygen (HBO) is accomplished when a patient is breathing 100% oxygen in an environment with increased barometric pressure. A typical HBO treatment protocol of diabetic foot ulcer involves 20 to 40 sessions. Treatment is usually given as daily 90- to 120-minute HBO sessions at pressures between 2.0 and 2.5 absolute atmospheres. The wide use of HBO as treatment of diabetic foot ulcers over the past decades has been founded on weak scientific ground (ie, few and small prospective studies with methodologic limitations on top of case series). However, the consistency in positive outcome in these trials evaluating HBO on ulcer healing is noteworthy because these findings are in concert with data from in vitro and physiologic studies supporting the theoretic framework of HBO reversing hypoxia-induced pathology. Two well-designed randomized double-blinded placebo-controlled studies have in recent years put HBO on firmer ground as treatment of a selection of diabetic patients with chronic foot. Some evidence indicates that microvascular parameters such as transcutaneous (partial) oxygen pressure (TcPO(2)) could be useful in predicting which patients will benefit from therapy. Health economic studies suggest potential cost-effectiveness of HBO. But because these analyses are limited by their deficient primary clinical data, they should be interpreted with caution. Thus, HBO is only indicated in a selected group of patients with chronic diabetic foot ulcers. Several key issues remain to be addressed such as developing robust criteria to determine which patients are likely to benefit and when to start and stop treatment.

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The Efficacy of Hyperbaric Oxygen Therapy in Improving the Quality of Life in Patients With Problem Wounds

Cited by 16 publications

References 16 publications

Fluorinated methacrylamide chitosan hydrogels enhance collagen synthesis in wound healing through increased oxygen availability

Fluorinated methacrylamide chitosan hydrogels enhance collagen synthesis in wound healing through increased oxygen availability

Hyperbaric oxygen therapy improves health‐related quality of life in patients with diabetes and chronic foot ulcer

What is the Role of Hyperbaric Oxygen in the Management of Diabetic Foot Disease?

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