The efficacy of intradermal injections of botulinum toxin in the management of enlarged facial pores and seborrhea: a split face-controlled study

Sayed, Khadiga S; Hegazy, Rehab A.; Gawdat, Heba I.; Hay, Rania Abdel; Ahmed, Mona; Mohammed, Faisal; Allam, Riham S H M; Fahim, Aya

doi:10.1080/09546634.2019.1708241

Cited by 25 publications

(46 citation statements)

References 18 publications

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“…Treatment: BoNT‐A, often used in a hyperdiluted form, can be useful for pore tightening in patients with increased sebum production, such as acne and rosacea. 39 , 40 HA can reduce pore size, 41 , 42 and hyperdiluted CaHA 43 can improve overall skin quality that encompasses pore size.…”

Section: Consensus Results/recommendationsmentioning

confidence: 99%

Skin Quality – A Holistic 360° View: Consensus Results

Goldie¹,

Kerscher²,

Fabi³

et al. 2021

CCID

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Introduction Skin quality is an important component of human attractiveness. To date, there are no standardized criteria for good skin quality. To establish a consensus for good skin quality parameters and measurement and treatment options, a virtual skin quality advisory board consisting of a global panel of highly experienced aesthetic dermatologists/aesthetic physicians was convened. Methods A total of 10 dermatologists/aesthetic physicians served on the advisory board. A modified version of the Delphi method was used to arrive at consensus. Members accessed an online platform to review statements on skin quality criteria from their peers, including treatment and measurement options, and voted to indicate whether they agreed or disagreed. Statements that did not have agreement were modified and the members voted again. Consensus was defined as: strong consensus = greater than 95% agreement; consensus = 75% to 95% agreement; majority consent = 50% to 75% agreement; no consensus = less than 50% agreement. Results There was strong consensus that good skin quality is defined as healthy, youthful in appearance (appearing younger than a person’s chronological age), undamaged skin and that skin quality can be described across all ethnicities by four emergent perceptual categories (EPCs): skin tone evenness, skin surface evenness, skin firmness, and skin glow. The EPCs can be affected by multiple tissue layers (ie, skin surface quality can stem from and be impacted by deep structures or tissues). This means that topical approaches may not be sufficient. Instead, improving skin quality EPCs can require a multilayer treatment strategy. Conclusion This global advisory board established strong consensus that skin quality can be described by four EPCs, which can help clinicians determine the appropriate treatment option(s) and the tissue or skin layer(s) to address. Skin quality is important to human health and wellbeing and patients’ perception for the need for aesthetic treatment.

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Section: Consensus Results/recommendationsmentioning

confidence: 99%

Skin Quality – A Holistic 360° View: Consensus Results

Goldie¹,

Kerscher²,

Fabi³

et al. 2021

CCID

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“…11,12 Although intradermal injection of 50 U/side ONA or 125 U/side ABO failed to show significant efficacy in sebum and facial pore reduction, 15 a recent split-face study showed that the intradermal BTX injectedside showed a significantly greater reduction in seborrhea at 1 month compared to that of the saline injected-side. 10 However, there was a limitation in that seborrhea was evaluated by a 4-point score rather than by objective quantification.…”

Section: Discussionmentioning

confidence: 99%

“…5 More recently, intradermal injection of BTX has been used off-label for various aesthetic conditions, including facial skin laxity, excess sebum production, and enlarged facial pores. [8][9][10][11][12][13] These effects could be attributed to the paralysis of arrector pili muscles or decreased sebum production via acetylcholine inhibition. 10,13,14 However, previous studies relied on subjective evaluation and lacked long-term clinical data.…”

mentioning

confidence: 99%

“…[8][9][10][11][12][13] These effects could be attributed to the paralysis of arrector pili muscles or decreased sebum production via acetylcholine inhibition. 10,13,14 However, previous studies relied on subjective evaluation and lacked long-term clinical data. Regarding sebum production or facial pore reduction, some studies showed conflicting results.…”

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confidence: 99%

“…Regarding sebum production or facial pore reduction, some studies showed conflicting results. 10,15 Additionally, previous studies applied intradermal injections of Abobotulinumtoxin-A (ABO) or Onaboulinumtoxin-A (ONA), but no currently published study used Incobotulinumtoxin-A (INCO) for these indications.…”

mentioning

confidence: 99%

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Intradermal Microdroplet Injection of Diluted Incobotulinumtoxin-A for Sebum Control, Face Lifting, and Pore Size Improvement

Park¹,

Cho²,

Hur³

et al. 2020

JDD

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Background: Intradermal injections of botulinum toxin have been reported to improve sebum secretion, facial skin laxity, and facial pores. However, the effects of Incobotulinumtoxin-A for these indications have not been reported. Objective: To evaluate the efficacy of Incobotulinumtoxin-A for the improvement of sebum secretion, face laxity, and facial pores. Materials and Methods: This single-center retrospective study included patients treated with Incobotulinumtoxin-A to improve facial skin laxity, sebum secretion, and facial pores. The microdroplet injection protocol included injection points on the lateral face, anterior medial cheek, mandibular line, depressor anguli oris points, mid-glabella area, and chin. Outcomes were measured using a Sebumeter and three-dimensional scanner and were evaluated by facial laxity ratings and the Global Aesthetic Improvement Scale. Results: Twenty patients were included in the analysis. Sebum secretion, mandibular length, facial pores, and facial laxity ratings were improved at 1 week and results were sustained through 12 weeks. All outcomes showed maximum improvement after 4 weeks. Evaluation using the Global Aesthetic Improvement Scale showed that all subjects reported at least a score of 2 (improved) after 4 weeks. Conclusion: This study showed that intradermal injection with Incobotulinumtoxin-A could be effective for face lifting, reduced sebum production, and improved facial pores.

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The history of botulinum toxin and its relationship to the skin

Couvillion¹,

Allen

2022

Dermatological Reviews

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Botulinum toxin was first identified as the cause of muscle paralysis in cases of food poisoning in the 1800s. Further study of the toxin gained insight into its mechanism of action and potential for therapeutic use. “Oculinum,” now known as onabotulinumtoxinA (Botox), was approved for clinical use in 1989 for the treatment of strabismus, blepharospasm, and hemifacial spasm. The first published cosmetic use was in 1992 describing successful treatment of glabellar lines. OnabotulinumtoxinA became approved for treatment of rhytides in 2002, followed by abobotulinumtoxinA (Dysport), incobotulinumtoxinA (Xeomin), and prabotulinumtoxinA‐xvfs (Jeuveau) in 2009, 2010, and 2019, respectively. Since the initial approval of onabotulinumtoxinA 20 years ago, neuromodulator injection has become the most popular nonsurgical aesthetic procedure in the world.

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The efficacy of intradermal injections of botulinum toxin in the management of enlarged facial pores and seborrhea: a split face-controlled study

Cited by 25 publications

References 18 publications

Skin Quality – A Holistic 360° View: Consensus Results

Skin Quality – A Holistic 360° View: Consensus Results

Intradermal Microdroplet Injection of Diluted Incobotulinumtoxin-A for Sebum Control, Face Lifting, and Pore Size Improvement

The history of botulinum toxin and its relationship to the skin

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