The Efficacy of Intravenous 0.15 Versus 0.25 mg/kg Intraoperative Morphine for Immediate Postoperative Analgesia After Remifentanil-Based Anesthesia for Major Surgery

Abstract

The administration of 0.15 or 0.25 mg/kg perioperative morphine during remifentanil-based anesthesia for major surgery does not preclude additional morphine administration in the postanesthesia care unit. The larger dose of 0.25 mg/kg slightly improves postoperative analgesia; however, it may be responsible for postoperative respiratory depression.

Remifentanil-propofol versus fentanyl-propofol for monitored anesthesia care during hysteroscopy

“…In the present study, remifentanil infusion was started at 0.05 μg/kg per minute initially and then adjusted between 0 and 0.1 μg/ kg per minute based on patient responses, which were chosen from previous studies of monitored anesthesia care [13,14]. Although remifentanil-based intraoperative analgesia has been associated with increased postoperative analgesic requirements [15,16], we did not see this situation in this study. This difference may be due to the unique pain characteristics of hysteroscopy.…”

Desflurane–remifentanil–nitrous oxide anaesthesia for abdominal surgery: optimal concentrations and recovery features

“…During intra-abdominal surgery, several authors have suggested to maintain an infusion rate of 0.5 mg kg À1 .min À1 (corresponding to a concentration around 15 ng ml À1 ) to block any response to surgical stimuli (24)(25)(26) but this may lead to hypotension (27) or severe bradycardia (24). A pharmacodynamic modelling performed by Drover and colleagues estimated the remifentanil EC 50 to block response between 5 and 7 ng ml À1 , and the EC 95 just above (21).…”

The Effect of Sufentanil Administration on Remifentanil-Based Anaesthesia during Laparoscopic Gynaecological Surgery: A Double-Blind Randomized Controlled Trial

“…However, this protocol presents problems, such as delayed recovery and postoperative respiratory depression [16, 17]. Haemodynamic instability is frequently encountered during emergence from remifentanil-based anaesthesia [18].…”