The efficacy of intravenous paracetamol versus tramadol for postoperative analgesia after adenotonsillectomy in children

Uysal, Hale Yarkan; Takmaz, Suna Akın; Yaman, Ferda; Baltaci, Bülent; Başar, Hülya

doi:10.1016/j.jclinane.2010.07.001

Cited by 68 publications

(62 citation statements)

References 25 publications

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“…A recent study compared the postoperative pain relief provided by paracetamol and tramadol in children after adenotonsillectomy and reported that paracetamol showed similar analgesic effects and provided early recovery (21). Another study reported that a tramadol/acetaminophen combination was superior to propoxyphene/acetaminophen in postoperative wound pain treatment (22). In the current study, we did not find a significant difference in the postoperative VAS scores of the patients in Group P compared to those in Group T. However, the greater need for additional analgesia in Group P may explain the lack of a significant difference between the VAS scores of the two groups.…”

Section: Discussioncontrasting

confidence: 82%

Comparison of the analgesic effects of paracetamol and tramadol in lumbar disc surgery

Yılmaz¹,

Sarihasan²,

Kelsaka³

et al. 2015

Turk J Med Sci

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IntroductionDespite developments in the pathophysiology and treatment of pain, increased knowledge of pain management, the availability of new drugs, and complex drug delivery systems, the pain management of many patients after surgery remains inadequate. Studies have shown that successful postoperative analgesia after surgery prevents many side effects of pain, such as the inability to breathe at ease, the increase in the workload of the cardiovascular system, the development of thromboembolic events due to a delay in the mobilization of patient, and the increase in stress response due to the activation of the sympathetic nervous and neuroendocrine systems (1,2). Inadequate treatment of acute pain is the most common cause of chronic pain after surgery. The aim after surgery is to ensure that organ functioning returns to normal quickly by controlling pain as soon as possible (3).Today it is possible to achieve successful postoperative analgesia by selecting appropriate methods/routes of administration, agents, dosages, and dosage ranges. Opioids are the most widely used group of drugs in the treatment of postoperative pain due to their strong analgesic activities. However, opioid-related nausea, vomiting, pruritus, urinary retention, respiratory depression, sedation, and central nervous system depression have accelerated the search for analgesic drugs with better pain relief efficacy and fewer side effects (4).Research has reported gastric irritation, erosion, bleeding, and inhibition of platelet aggregation with nonsteroidal antiinflammatory drugs (NSAIDs), in addition to adverse effects on the secretion of uric acid and bleeding (5), thereby restricting their use. Side effects, such as systemic toxicity and prolonged sensory and motor responses, have also been reported with local anesthetic drugs used to provide pain control (6). Tramadol, a weak, effective synthetic opioid, has been shown to have relatively few side effects compared to other opioids, and its abuse or addiction potential is negligible (7). Paracetamol is a Background/aim: To compare the postoperative analgesic efficacy and side effects of paracetamol and tramadol in patients undergoing lumbar disc surgery. Materials and methods: Group P (paracetamol group) was given 1 g of paracetamol intravenously 30 min before the end of the operation and 1 g each day at 6-h intervals. Group T (tramadol group) was given 1.5 mg/kg of tramadol as a loading dose and patient-controlled analgesia for 1 day. Hemodynamic parameters, modified Aldrete score, Ramsay sedation scale score, patient satisfaction scale (PSS) score, visual analog scale (VAS) score, nausea/vomiting scale score, and additional analgesic needs/times were recorded.Results: PSS scores were significantly higher in Group T (P < 0.05). The total analgesic consumption was significantly higher in Group P. There were no significant differences in the VAS scores at any time points. Twenty-one patients in Group P and 8 patients in Group T needed additional analgesia (P < 0.05). The first additional analg...

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Section: Discussioncontrasting

confidence: 82%

Comparison of the analgesic effects of paracetamol and tramadol in lumbar disc surgery

Yılmaz¹,

Sarihasan²,

Kelsaka³

et al. 2015

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…Acetaminophen inhibits cyclooxygenase activity (COX-3) in central nervous system (CNS). In addition, paracetamol is a weak COX-1 and COX-2 inhibitor (anti-inflammatory effect) (8,13,19). In this study, measurements of blood pressure and heart rate in patients throughout the study period suggest that paracetamol does not have cardiovascular effects.…”

Section: Discussionmentioning

confidence: 62%

“…Preventive analgesia includes any intraoperative analgesic agents able to control pain-induced sensitization of the central nervous system (CNS), hence to decrease both the development and the persistence pain (7). Paracetamol (intravenous acetaminophen) is a non-opioid analgesic that is devoid of risks related to opioids (8,9). The postoperative use of paracetamol has been shown to decrease acute pain after various surgical procedures (10).…”

Section: Introductionmentioning

confidence: 99%

Preventive Analgesia with Intravenous Paracetamol for Post-cesarean section Pain Control

Atashkhoyi¹,

Rasouli²,

Fardiazar³

et al. 2014

IJWHR

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Objectives: Effective pain therapy after cesarean section is essential for parturient comfort and to allow early ambulation to facilitate care of her infant. This study evaluated the analgesic effect of preventive 1gr intravenous paracetamol on postoperative pain and analgesic consumption during the 24 hours after cesarean section. Materials and Methods: One-hundred American Society of Anesthesiologists (ASA) I or II status parturient scheduled for elective cesarean section under spinal anesthesia. Patients received 1gr iv paracetamol into 100 ml normal saline (study group; n=50) or normal saline alone (placebo group; n=50) 20 minutes before the end of operation. Results: Pain scores were lower in the study group in the Post anesthesia care unit (PACU) (p<0.001) and up to 4h after operation (p<0.001). Cumulative analgesic consumption was lower in the study group (p<0.001). Conclusion: Preventive administration of 1gr iv paracetamol reduces the intensity of pain in the PACU and until 4h after operation and analgesic consumption following cesarean section.

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“…[19,20] A systematic meta-analysis has revealed that IV acetaminophen reduces nausea when prophylactically administered either before surgery or before arrival in the post-anesthesia care unit; but not when administered after the onset of pain. [15] Consistent with these results; the incidence of nausea and vomiting during the first 0-6 h postoperatively was found to be lower in patients who received preoperative paracetamol than in those who received postoperative paracetamol in our study.…”

Section: Discussionmentioning

confidence: 99%

The effect of intravenous preoperative versus postoperative paracetamol on postoperative nausea and vomiting in patients undergoing strabismus surgery: A prospective randomised study

Aksoy

İnce²,

Ahişkalıoğlu³

et al. 2018

Agri

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SummaryObjectives: This prospective randomized study aimed to compare the efficacy of preoperative versus postoperative paracetamol on postoperative nausea and vomiting (PONV) in children undergoing strabismus surgery. Methods: Ninety-six patients were randomly divided into three equal groups (n=32). In the preoperative paracetamol group, patients received intravenous (IV) infusion of paracetamol [15 mg kg −1 (1.5 ml kg)] 1 h before surgery over 20 min and that of saline (1.5 ml kg −1 ) in the recovery room. In the postoperative paracetamol group, patients received IV infusion of saline (1.5 ml kg )] in therecovery room. In the control group, patients received the IV infusion of saline (1.5 ml kg −1 ) pre-and postoperatively. Postoperative pain condition was evaluated using the Faces Pain Scale. In the recovery room, an observer recorded the pain score, complaints of nausea and vomiting, the need for rescue analgesics, and the need for antiemetic drug during 24 h postoperatively. Results: The incidence of nausea and vomiting during the first 0-6 h postoperatively was significantly lower in the preoperative paracetamol group than in the control and postoperative paracetamol groups (p<0.001). The number of patients requiring antiemetic administration during the first 0-6 and 6-12 h postoperatively was found to be higher in the control group than in the other groups (p<0.001, for all). Conclusion:The preoperative administration of paracetamol reduces PONV incidence in children undergoing strabismus surgery.

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The efficacy of intravenous paracetamol versus tramadol for postoperative analgesia after adenotonsillectomy in children

Cited by 68 publications

References 25 publications

Comparison of the analgesic effects of paracetamol and tramadol in lumbar disc surgery

Comparison of the analgesic effects of paracetamol and tramadol in lumbar disc surgery

Preventive Analgesia with Intravenous Paracetamol for Post-cesarean section Pain Control

The effect of intravenous preoperative versus postoperative paracetamol on postoperative nausea and vomiting in patients undergoing strabismus surgery: A prospective randomised study

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