The Efficacy of Laparoscopic Sleeve Gastrectomy in Treating Adolescent Obesity

Al-Sabah, Salman; Almazeedi, Sulaiman; Dashti, Shaimaa A.; Al-Mulla, Ahmed; Ali, Daliya AlMohammad; Jumaa, Talib

doi:10.1007/s11695-014-1340-9

Cited by 42 publications

(20 citation statements)

References 12 publications

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“…These findings may explain our borderline association of the rs9939609 with the BMI; however, this needs to be replicated further in other cohorts in the population. The FTO variant has been reported to be involved in weight regain after bariatric surgery [23] which is considered a common obesity intervention in the Kuwaiti population [24], and therefore identifying patients at high risk of weight regain prior to intervention may help in planning the course of treatment.…”

Section: Discussionmentioning

confidence: 99%

Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

et al. 2018

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Objective: To investigate the effect of the common fat mass and obesity-associated (FTO) gene polymorphism rs9939609 on body mass index (BMI) in one of the most obese populations worldwide. Subjects and Methods: Genotypic data for FTO rs9939609 were available for 1,034 unrelated Kuwaiti adults obtained from Kuwait’s Dasman Diabetes Institute and Kuwait University. The association between the FTO polymorphism with BMI as continuous and categorical (normal BMI [< 25] vs. overweight/obese [> 25]) variables was analyzed using both linear and logistic regression models, respectively, with the assumption of both dominant and additive genetic models performed using the SNPassoc package from R statistics. Results: The A allele was associated with increased BMI (β = 1.21; 95% CI = 0.16–2.26; p = 0.023). In concordance, the categorical BMI (normal vs. overweight/obese) also showed a significant association between the A allele and overweight/obesity (OR = 1.47; 95% CI = 1.01–2.12; p = 0.041). However, no association between the FTO variant was observed with cardiometabolic traits. Conclusion: We observed an association between the common FTO rs9939609 polymorphism and increased BMI (overweight/obesity) in Kuwaiti adults, which is consistent with previous research in other populations. Our findings encourage further investigation of genetic variants to elucidate the mechanisms involved in the development of obesity in such an obesogenic population.

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Section: Discussionmentioning

confidence: 99%

Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

et al. 2018

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“…In morbidly obese adolescent with coexisting comorbidities and no response to non-surgical therapy, surgery should be offered early in life before these conditions become irreversible. [14][15][16] In present study, overall post-operative complication rate was 5.0 % (two cases). These included one cases of gastroesophageal reflux disorder, and two cases of protein caloric malnutrition were identified.…”

Section: Discussionmentioning

confidence: 78%

OAGB/MGB for childhood and adolescent patients: a report of 20 cases done at a single centre in India

Bhandari

Mathur

et al. 2018

Int Surg J

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INTRODUCTIONThe prevalence of obesity among adolescents is rising in the recent decades specifically in developed countries around the world. Childhood obesity can lead to adulthood obesity, which reduces lifespan and decreases the quality of life. 1 Nowadays, the incidence of obesity at all ages have been doubled in the developing countries including India. According to a report from urban South India, 21.4 % of boys and 18.5% of girls aged 13-18 years were overweight or obese. 2 The prevalence of obesity among school children in India has been reported between 5.74% and 8.82%. 3,4 Overweight childhood and adolescent have augmented risk of being overweight as adults. The various factors like genetics, behavior, and family environment play a role in childhood overweight. Childhood overweight increases the risk for certain medical and psychological conditions. 5 Multiple ABSTRACT Background: Morbid obesity has risen in an alarming rate in children and adolescent patients. Bariatric surgery is playing an increasing role in pediatric surgery. However, current evidence is limited regarding its safety and outcome. The aim of this study is to evaluate the efficacy of Mini/One Anastomosis Gastric Bypass (MGB/OAGB) in treating obesity and its co-morbidities among childhood and adolescent patients. Methods: A retrospective study was conducted of patients aged <18 who underwent OAGB/MGB in this series at Mohak Bariatric and Robotic Surgery Center (MBRSC) is a tertiary-care center. The major outcome measures were percent excess body weight loss (%EBWL) over a 2-year follow-up period, resolution of co-morbidities, and occurrence of complications. Results: A total of 20 childhood and adolescent patients underwent the procedure, of which, 11 (55.0%) of being males. The patients had a median age of 15 years (range 6-18). The average age was 15.5±3.17 year (range 6-18 years). The initial average weight and BMI was 112.13±26.52 Kgs and 40.86±8.17 kg/m 2 respectively. Postoperative average weight loss was 28 kgs, 33 kgs and 37.2 kgs in 6 months, 1 st year and 2 nd year respectively. The %EBWL at 1st and 2nd years was 75% and 80% respectively. Overall post-operative complication rate was 5.0% (two cases) of which one had gastroesophageal reflux and the other had protein caloric malnutrition. There was no mortality in this series at any time. Conclusions: The OAGB/MGB operation is a safe and effective option for childhood and adolescent patients with severe obesity. There is need for both long-term follow up, prospective, multicentre and larger series studies to confirm the findings in this study.

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“…Bariatric surgery is, in fact, highly effective within the adolescent population and can result in loss of 58–73% of excess weight(18, 33–40) (Figure 1). Although fewer studies have been performed in this population and long-term follow-up data are only now evolving, the initial studies(15–18, 41) show that T2D remission mirrors that which is observed in older patients. In a large, recent 3-year longitudinal study of adolescent bariatric surgery(16) (Table 1), 95% of patients with T2D at baseline exhibited remission by 3 years; prevalence of remission did not differ after VSG versus RYGB, but this may reflect the relatively small numbers of patients with T2D in the study (13%).…”

Section: Bariatric Surgery As a T2d Treatmentmentioning

confidence: 98%

“…Inspired by success as a treatment for adult obesity, bariatric surgery has recently emerged as a treatment for adolescent patients as well. Clinical studies (10–14) demonstrate a clear effect of bariatric surgery to improve glycemic control and often elicit complete remission of T2D, including in adolescents (15–18). This review will discuss the potential for bariatric surgery as a treatment for T2D in obese and overweight adolescents.…”

Section: Introductionmentioning

confidence: 99%

Bariatric Surgery for Adolescents with Type 2 Diabetes: an Emerging Therapeutic Strategy

Stefater

Inge

2017

Curr Diab Rep

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Purpose of Review Type 2 diabetes (T2D) is a growing public health problem in youth, but conventional treatments are often insufficient to treat this disease and its comorbidities. We review evidence supporting an emerging role for bariatric surgery as a treatment for adolescent T2D. Recent Findings Paralleling what has been seen in adult patients, bariatric surgery dramatically improves glycemic control in patients with T2D. In fact, remission of T2D has been observed in as many as 95–100% of adolescents with diabetes after bariatric surgery, particularly vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) surgery. This striking outcome may be due to both weight-dependent- and weight-independent factors and recent studies suggest T2D-related comorbidities may also improve after surgery. Summary Bariatric surgery including RYGB and VSG is a powerful therapeutic option for obese adolescents with T2D. Benefits must be weighed against risk for postoperative complications such as nutritional deficiencies, but earlier surgical intervention might lead to more complete metabolic remission in obese patients with T2D.

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The Efficacy of Laparoscopic Sleeve Gastrectomy in Treating Adolescent Obesity

Abstract: SG seems to be an effective and safe bariatric procedure in obese adolescents, as it can significantly decrease excess body weight and reduce co-morbidities in a relatively short period of time.

Cited by 42 publications

References 12 publications

Association of <b><i>FTO</i></b> rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

Association of <b><i>FTO</i></b> rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

OAGB/MGB for childhood and adolescent patients: a report of 20 cases done at a single centre in India

Bariatric Surgery for Adolescents with Type 2 Diabetes: an Emerging Therapeutic Strategy

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