The efficacy of laser-assisted hair removal in the treatment of acne keloidalis nuchae; a pilot study

Esmat, Samia; Hay, Rania Abdel; Zeid, Ola M. Abu; Hosni, Hasnaa A.

doi:10.1684/ejd.2012.1830

Cited by 37 publications

(22 citation statements)

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“…9 Laser-assisted hair removal causes coagulation necrosis of the viable hair follicles and hair shafts in the deep dermis, and has shown positive results for AKN. 10,11 In tattoos, using nanosecond Q-switched laser pulses, the ink particles are fragmented into smaller pieces, which can then be phagocytosed by macrophages and cleared from the skin via the lymph vessels to the draining lymph nodes. 12 The aim of this study was to evaluate the efficacy of LT cream compared with LP cream in reducing self-reported pain during laser treatments of AKN (study A) and tattoos (study B).…”

Section: What Does This Study Add?mentioning

confidence: 99%

“…AKN is a chronic, scarring folliculitis in which hair follicles are the principle contributors to inflammation . Laser‐assisted hair removal causes coagulation necrosis of the viable hair follicles and hair shafts in the deep dermis, and has shown positive results for AKN . In tattoos, using nanosecond Q‐switched laser pulses, the ink particles are fragmented into smaller pieces, which can then be phagocytosed by macrophages and cleared from the skin via the lymph vessels to the draining lymph nodes …”

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confidence: 99%

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Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anaesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials

et al. 2016

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SummaryBackground Pain is a common adverse effect of dermatological laser procedures. Currently, no standard topical anaesthetic cream exists for deeper dermal laser procedures. Objectives To compare the efficacy of lidocaine/tetracaine cream and lidocaine/ prilocaine cream in reducing self-reported pain during deeper dermal laser treatment of acne keloidalis nuchae (AKN) and tattoos. Methods We conducted two randomized, double-blind, controlled clinical trials with intrapatient, split-lesion designs: study A included patients with AKN (n = 15); study B included patients with black tattoos (n = 15). The primary end point was the patients' self-reported pain on a 10-cm visual analogue scale (VAS). Secondary objectives were the percentage of patients with adequate pain relief, willingness to pay €25 for the cream that provided the best pain relief and safety of the creams. Results In both studies, VAS scores were lower for lidocaine/prilocaine cream, with a mean VAS difference in study A of 1Á9 [95% confidence interval (CI) 1Á0-2Á8] and in study B of 0Á6 (95% CI À0Á7 to 1Á9). In study A, adequate pain relief was achieved in 13% (n = 2) with lidocaine/tetracaine cream vs. 73% (n = 11) with lidocaine/prilocaine cream (P = 0Á004), and in study B in 53% (n = 8) vs. 80% (n = 12), respectively (P = 0Á289). In study A, 47% (n = 7) were willing to pay an additional €25 vs. 73% (n = 11) in study B. No serious adverse events occurred. Conclusions Lidocaine/prilocaine cream under plastic occlusion is the preferred topical anaesthetic during painful laser procedures targeting dermal chromophores.

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Section: What Does This Study Add?mentioning

confidence: 99%

mentioning

confidence: 99%

Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anaesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials

et al. 2016

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“…Intralesional corticosteroids should be considered for a resistant cases and for the treatment of keloidal scarring (10). Laser therapy should be considered for the hair removal and/or softening of the keloidal plaques (17,18). Several authors have reported that laser hair removal is an option to prevent relapsing folliculitis (13).…”

Section: Discussionmentioning

confidence: 99%

Acne Keloidalis Nuchae – Case Report

Ogorelica

Gajinov

Matović

et al. 2019

Serbian Journal of Dermatology and Venereology

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Acne keloidalis nuchae (AKN) / folliculitis keloidalis nuchae (FKN) is a chronic inflammatory condition which involves hair follicles localized predominantly in occipital scalp and posterior neck area leading to hypertrophic scarring alopecia. We present a 59-year-old factory worker, Caucasian male with a whitish alopecic oval plaque about 10 cm in diameter in the occipital region. The peripheral part of plaque was mildly inflammated, with groups of tufted terminal hairs, while the central part showed cicatricial alopecia and discrete non-adherent dry scales. Skin changes firstly occurred 6 years earlier, as itchy papules and pustules that sometimes healed with scarring. The applied relevant diagnostic and therapeutical measures are discussed in this report.

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“…Despite the high prevalence of AKN in men of African descent, there have been only very few interventional studies examining the effects of nonsurgical, minimally invasive treatments. One recent study assessed the efficacy of neodymium‐doped yttrium aluminium garnet (Nd‐YAG) laser‐assisted hair removal in AKN and concluded that the destruction of hair follicles after five treatments over 4 months had potential in improving both papules and plaques in AKN . The rationale for laser hair removal for AKN is that destruction of the hair follicle removes the nidus of inflammation and may prevent subsequent fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Improving acne keloidalis nuchae with targeted ultraviolet B treatment: a prospective, randomized, split‐scalp comparison study

et al. 2014

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Background Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis with fibrotic papules on the occipital scalp. Its treatment is limited and unsatisfactory. Objectives To determine if targeted ultraviolet B (tUVB) phototherapy will (1) improve the clinical appearance of AKN and (2) induce extracellular matrix remodeling in affected lesions. Methods Eleven patients with AKN were enrolled in a prospective, randomized, split-scalp comparison study. One randomly selected side of the scalp was treated with tUVB up to three times weekly for eight weeks. After week 8, both sides were treated for eight additional weeks. Assessment included lesion counts in two 3×3 cm regions of interest (ROI), one on each side of the scalp (ROI-1: tUVB week 0–16, ROI-2: tUVB week 9–16), patient self-assessment, and analysis of MMP-1, MMP-9, TGF-β1, and Col1a1 mRNA expression by qRT-PCR. Results Before treatment, the mean lesion count was similar between tUVB-treated and untreated sides (14.8 vs. 15.0). After eight weeks of tUVB, the mean lesion count decreased significantly to 9.4±1.2 (P=0.03), with no change on the untreated side. With continued treatment, the mean lesion count in ROI-1 decreased further to 7±1.5 (P=0.04) after 16 weeks of tUVB. Conclusion Targeted UVB significantly improved clinical appearance of AKN, led to patient satisfaction, and was well tolerated.

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The efficacy of laser-assisted hair removal in the treatment of acne keloidalis nuchae; a pilot study

Cited by 37 publications

References 0 publications

Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anaesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials

Comparison of lidocaine/tetracaine cream and lidocaine/prilocaine cream for local anaesthesia during laser treatment of acne keloidalis nuchae and tattoo removal: results of two randomized controlled trials

Acne Keloidalis Nuchae – Case Report

Improving acne keloidalis nuchae with targeted ultraviolet B treatment: a prospective, randomized, split‐scalp comparison study

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