The efficacy of Li in bipolar disorder

Influence of hypothyroidism on renal function of lithium-treated patients

“…Indeed, we know that lithium produces thyroid dysfunction (eg, raised thyroid-stimulating hormone and decreased free thyroxine, among other alterations) 4 , 5 in a high proportion of patients. We also know that there is a close relationship between thyroid and renal function, with hypothyroid patients displaying elevated serum creatinine levels, characterized by slower and incomplete recovery after prolonged periods of severe hypothyroidism, and reductions in glomerular filtration rate.…”