The efficacy of mesenchymal stem cells in regenerating structures associated with the temporomandibular joint: A systematic review

Pagotto, Luís Eduardo Charles; Santos, Thiago de Santana; Pastore, Gabriel Pires

doi:10.1016/j.archoralbio.2021.105104

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…Such therapy could shift the indications for arthroscopy and open surgery of TMJs towards more severe morphological disorders [22,29,30]. The latest clinical research sees the most promising solution in the transplantation of autologous mesenchymal stem cells (MSCs), primarily from adipose tissue [23,[31][32][33]. Unfavorably, the implantation of fat preparations carries the risk of iatrogenic embolism, which can even lead to vision loss [34][35][36].…”

Section: Introduction 1rationalementioning

confidence: 99%

Injectable Platelet-Rich Fibrin (I-PRF) Administered to Temporomandibular Joint Cavities: A Scoping Review

Sielski¹,

Chęcińska

Chęciński³

et al. 2023

JCM

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The aim of this review was to systematically map the research on the intra-articular administration of injectable platelet-rich fibrin (I-PRF) to the temporomandibular joints (TMJs). Medical databases covered by the ACM, BASE, Google, NLM, and ResearchGate were searched on 23 February 2023. The assessment of the level of evidence was based on the Oxford Center for Evidence-Based Medicine 2011 scale. The risk of bias was assessed for randomized controlled trials with the RoB2 tool. Extracted data were tabulated, and the changes in effect values were calculated. A total of eight studies qualified, of which five trials on 213 patients were randomized and controlled (RCTs). In each of the RTC study groups, arthrocentesis was performed, and 1–2 mL per joint of I-PRF (700 rpm/3 min/60 g centrifugation) was administered. Articular pain in three months decreased to 0–25% of the initial pre-interventional values in the study and 38–50% in the control groups. Mandible mobility increased to 121–153% and 115–120% in the I-PRF groups and controls, respectively. The main limitations of the evidence were the small number of RCTs and the lack of any RCT study groups receiving I-PRF without prior arthrocentesis. In conclusion, supplementing the temporomandibular joint rinsing with I-PRF administration further relieves pain and improves mandible mobility. The lack of RCTs on the intra-articular administration of I-PRF as a stand-alone procedure encourages further research. This research received no external funding. The review protocol has not been previously published.

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Section: Introduction 1rationalementioning

confidence: 99%

Injectable Platelet-Rich Fibrin (I-PRF) Administered to Temporomandibular Joint Cavities: A Scoping Review

Sielski¹,

Chęcińska

Chęciński³

et al. 2023

JCM

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“…Among these, we can mention non-invasive ones such as patient education, pharmacotherapy, physiotherapy, interocclusal splints, prosthetic rehabilitation, and/or minimally invasive such as arthrocentesis, hyaluronic acid injections, intra-articular injections of corticosteroids, platelet-rich plasma (PRP), oxygen–ozone therapy, and arthroscopy [ 11 , 12 , 13 , 14 ]. In some cases considered as severe, when patients do not respond to the conservative treatments, more invasive and intra-articular surgical interventions are required [ 13 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Stem cells can be derived from two main sources, which are embryonic stem cells (ESCs) and adult stem cells, including mesenchymal stem cells (MSCs), the most widely used in TMJ [ 16 ]. The use of these cells occurs at the process of repairing damaged tissues or those with impaired function, in order to replace and repair their normal physiology, in addition to suppressing and modulating the inflammatory process [ 11 , 15 , 17 ]. This would provide a decrease in painful symptoms, prevent progressive degeneration of cartilage and subchondral bone, therefore favoring the reestablishment of TMJ function [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Global Trends and Future Research Directions for Temporomandibular Disorders and Stem Cells

Silva

Melo

Ferreira

et al. 2023

JFB

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Temporomandibular disorder (TMD) is an umbrella term used to describe various conditions that affect temporomandibular joints, masticatory muscles, and associated structures. Although the most conservative and least invasive treatment is preferable, more invasive therapies should be employed to refractory patients. Tissue engineering has been presented as a promising therapy. Our study aimed to investigate trends and point out future research directions on TMD and stem cells. A comprehensive search was carried out in the Web of Science Core Collection (WoS-CC) in October 2022. The bibliometric parameters were analyzed through descriptive statistics and graphical mapping. Thus, 125 papers, published between 1992 and 2022 in 65 journals, were selected. The period with the highest number of publications and citations was between 2012 and 2022. China has produced the most publications on the subject. The most frequently used keywords were “cartilage”, “temporomandibular joint”, “mesenchymal stem cells”, and “osteoarthritis”. Moreover, the primary type of study was in vivo. It was noticed that using stem cells to improve temporomandibular joint repair and regeneration is a significant subject of investigation. Nonetheless, a greater understanding of the biological interaction and the benefits of using these cells in patients with TMD is required.

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“…In its course, it was possible to collect bone marrow MSCs, differentiate them in vitro towards chondrocytes and implant them into the joints of animals [ 24 ]. A systematic review of the use of stem cells in the treatment of TMJs was published in 2021 by Pagotto et al [ 62 ]. These researchers qualified six animal studies and two clinical studies [ 62 ].…”

Section: Introductionmentioning

confidence: 99%

“…A systematic review of the use of stem cells in the treatment of TMJs was published in 2021 by Pagotto et al [ 62 ]. These researchers qualified six animal studies and two clinical studies [ 62 ]. During the initial searches in preparation for this paper, it was found that adopting different criteria allowed for the inclusion of more human studies and thus for other systematic review objectives.…”

Section: Introductionmentioning

confidence: 99%

Autologous Stem Cells Transplants in the Treatment of Temporomandibular Joints Disorders: A Systematic Review and Meta-Analysis of Clinical Trials

Chęciński¹,

Chęcińska

Turosz³

et al. 2022

Cells

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This systematic review aims to analyze the outcomes of the treatment of temporomandibular joint (TMJ) articular pain (AP) and restricted maximum mouth opening (MMO) with intra-articular administration of mesenchymal stem cells (MSCs). The inclusion criteria allowed primary studies involving AP and/or MMO pre-treatment and post-intervention values. Medical databases that were covered by ACM Digital, BASE, EBSCOhost, Google Scholar, PubMed, Scopus, and Web of Science engines were searched. The risk of bias was assessed with RoB 2 and ROBINS-I tools. The results were tabulated, plotted, and analyzed for regression. A total of 5 studies involving 51 patients/69 TMJs were identified, and 4 studies on 50 patients/67 TMJs were synthesized. Interventions were each time effective in decreasing AP and increasing MMO in a 6-month follow-up period by an average of about 85% and over 40%, respectively. Regression analysis showed a good fit of the logarithmic model for AP relief (5.8 − 0.8 ln x; R2 = 0.90) and MMO increase (33.5 + 2.4 ln x; R2 = 0.89). The results for AP and MMO were based on 3 studies in 39 patients and 4 studies in 50 patients, respectively, all at high risk of bias. The intra-articular administration of MSCs to TMJs, based on weak evidence, may be highly effective in reducing AP and improving MMO. This study received no funding.

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The efficacy of mesenchymal stem cells in regenerating structures associated with the temporomandibular joint: A systematic review

Cited by 6 publications

References 26 publications

Injectable Platelet-Rich Fibrin (I-PRF) Administered to Temporomandibular Joint Cavities: A Scoping Review

Injectable Platelet-Rich Fibrin (I-PRF) Administered to Temporomandibular Joint Cavities: A Scoping Review

Global Trends and Future Research Directions for Temporomandibular Disorders and Stem Cells

Autologous Stem Cells Transplants in the Treatment of Temporomandibular Joints Disorders: A Systematic Review and Meta-Analysis of Clinical Trials

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