The efficacy of microsurgery in the treatment of cerebral aneurysm rupture and its effect on NF-κB, MCP-1 and MMP-9

Abstract

The clinical efficacy of microsurgical neck clipping for the treatment of cerebral aneurysm rupture and its effect on serum nuclear factor κ-light-chain-enhancer of activated β cells (NF-κB), monocyte chemoattractant protein-1 (MCP-1) and matrix metalloproteinase-9 (MMP-9) levels were investigated. A total of 56 patients with first occurrence of cerebral aneurysm rupture were enrolled from June 2015 to June 2016. These patients were divided into control (25 patients) and observation groups (31 patients) according to treatment received. The patients in the control group were treated with interventional embolization and extraventricular drainage, while the patients in the observation group were treated with microsurgical neck clipping. Serum NF-κB, MCP-1 and MMP-9 levels were measured by ELISA prior to the operation and at 6 h post-operation. Clinical effects were compared at the 6-month follow-up. There was no significant difference in the success rate of the operation between the two groups (p>0.05). The incidence of complications in the observation group was significantly lower than that in the control group (p<0.05). The Glasgow Outcome Scale score was significantly improved in the observation group (p<0.05) compared with the control group. Serum NF-κB, MMP-9 and MCP-1 were significantly decreased in both groups at 6 and 24 h after operation, but the observational group showed significantly lower levels for all three proteins than the control group (p<0.05). The application of early microsurgical neck clipping for the treatment of cerebral aneurysm rupture can reduce complications and improve clinical prognosis, and this may be related to a decrease in serum inflammatory response-related factors (NF-κB and MCP-1) and MMP-9.

Noninvasive Vagus Nerve Stimulation Prevents Ruptures and Improves Outcomes in a Model of Intracranial Aneurysm in Mice

“…MMP-9, the main gelatinase produced by macrophages, is associated with cerebral aneurysm rupture, and may predict poor prognosis. 5,8,24 MMP-9 also plays a critical role in outward vascular remodeling in a mouse common carotid artery ligation model. 25 VNS has been shown to reduce MMP-9 expression in macrophages, 9,26 and prevent abdominal aortic aneurysm formation by suppressing inflammatory cytokines and MMP activity.…”

Increased Levels of Serum IL-15 and TNF-β Indicate the Progression of Human Intracranial Aneurysm

“…Aoki et al (2009) demonstrated that the expression of MCP-1 was up-regulated in human UIAs, which consistent with our study. In patients with ruptured IAs, the serum levels of MCP-1 were also up-regulated and could predict poor outcomes; in contrast, serum MCP-1 levels gradually decreased after these patients were treated with microsurgical clipping (Kim et al, 2008;Zhang et al, 2017). These findings suggest MCP-1 as a potential biomarker in either unruptured or ruptured intracranial aneurysms.…”

Application of three dimensional (3D) curved multi‐planar reconstruction images in 3D printing mold assisted eyebrow arch keyhole microsurgery

“…Multi‐planar reconstruction is a method for displaying 3D datasets and allows for the generation of cross‐sectional images, such as original two‐dimensional coronal, sagittal, and oblique images. The multi‐planar reconstruction of the curve is perpendicular to the cross‐sectional image of a particular curve made by the user (Ota, Matsukawa, & Noda, 2018; Zhang, Chen, Zheng, & Du, 2017). The 3D digital image has been upgraded to form a 3D material object.…”