The efficacy of oral cyproterone acetate in combination with ethinyloestradiol in acne tarda of the facial type

Gollnick, Harald; Albring, Manfred; Brill, K.

doi:10.3109/09546639809161376

Cited by 26 publications

(19 citation statements)

References 14 publications

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“…Diese Präparate sind zur Behandlung androgenabhängiger Erkrankungen der Frau, einschließlich der mittetschweren bis schweren Aknebehandlung zugelassen, hat aber gleichzeitig eine volle kontrazeptive Wirkung. Mit dem Ende einer 6-monatigen Therapie war neben einer Besserung der Akne bei 64,3 % auch eine Verschlechterung bei 4,9 % der Frauen zu beobachten (Evidenzebene 4 -eine Studie n = 890 [38]). Alternativ kann zu Beginn des Menstruationszyklus eine einzelne i.m.-Injektion mit 100 bis 300 mg Cyproteronacetat (Androcur ® Depot) verabreicht werden.…”

Section: Cyproteronacetatunclassified

Hormonelle Antiandrogene in der Aknetherapie

Zouboulis

Rabe

2010

J Deutsche Derma Gesell

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Hormonal antiandrogen treatment is limited to female patients who present additional signs of peripheral hyperandrogenism or hyperandrogenemia. In addition, females with acne tarda, persistent acne recalcitrant to treatment, with parallel wish of contraception, and as a requirement for a systemic isotretinoin treatment can be treated with hormonal antiandrogens. Hormonal antiandrogen treatment is not a primary monotherapy for uncomplicated acne.

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Section: Cyproteronacetatunclassified

Hormonelle Antiandrogene in der Aknetherapie

Zouboulis

Rabe

2010

J Deutsche Derma Gesell

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“…Only one study was a randomized trial, but used subjective dermatological measurements, such as "complete healing" and "definitive healing" to assess treatment efficacy (76). Other studies were not randomized trials (77,78) and only one used an objective dermatological measure such as lesion count to assess treatment efficacy (78). In ail, these studies reported 60% to 73% in improvement compared to baseline (76)(77)(78).…”

Section: 62t1 Tetracycune Minocycline and Doxycycljnementioning

confidence: 99%

“…Other studies were not randomized trials (77,78) and only one used an objective dermatological measure such as lesion count to assess treatment efficacy (78). In ail, these studies reported 60% to 73% in improvement compared to baseline (76)(77)(78).…”

Section: 62t1 Tetracycune Minocycline and Doxycycljnementioning

confidence: 99%

Isotretinoin and the Risk of Depression in Patients With Acne Vulgaris

Azoulay¹,

Blais²,

Koren³

et al. 2008

J. Clin. Psychiatry

129

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“…Several studies have demonstrated that combined oral contraceptives (OC) can be an effective treatment for acne in women. [2][3][4][5] Recent epidemiological studies from Denmark suggest that use of OC appears to be associated with a reduced prevalence of acne in adolescent girls. 6 The antiandrogen effects of OC are due to a reduction of ovarian androgen production (due to inhibition of follicle-stimulating and luteinizing hormones) and a decrease in circulating testosterone (due to elevating sex hormoneebinding globulin).…”

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confidence: 98%