1994
DOI: 10.1046/j.1525-1438.1994.04020084.x
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The efficacy of postoperative vaginal irradiation in preventing vaginal recurrence in endometrial cancer

Abstract: Between 1960 and 1985 hysterectomy was performed on 811 FIGO stage I and 116 stage II endometrial cancers which were divided into three groups: low-risk stage Ii (grade 1 and 2 lesions confined to the inner third of the myometrium; high-risk stage Iii (grade 3 and/or invading to the middle third of the myometrium or beyond); and FIGO stage II tumors (also high-risk). Hysterectomy was the only treatment in 492; in 145 the vaginal vault alone was radiated and in 290 the whole vagina, in each instance by an intra… Show more

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Cited by 94 publications
(36 citation statements)
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“…Our results were comparable with those of other centers and, as in other series, the most important prognostic factors tended to be the tumor grade and depth of myometrial invasion [6,9,[12][13][14]. There was a trend toward an association between the final BED for rectal tissue and late complications, but without statistical significance.…”
Section: Discussionsupporting
confidence: 89%
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“…Our results were comparable with those of other centers and, as in other series, the most important prognostic factors tended to be the tumor grade and depth of myometrial invasion [6,9,[12][13][14]. There was a trend toward an association between the final BED for rectal tissue and late complications, but without statistical significance.…”
Section: Discussionsupporting
confidence: 89%
“…The most common location of recurrence is at the vaginal apex, with a relative frequency of 4:1 [6,9].…”
Section: Discussionmentioning
confidence: 99%
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“…In clinical stage I, approximately 5-20% of patients who were treated with TAH and bilateral salpingo-oophorectomy alone develop vaginal and pelvic recurrences, which were associated with deep myometrial invasion, undifferentiated tumors, lymphovascular space invasion and advanced stage [7,8,9,10,11,12,13]. …”
Section: Introductionmentioning
confidence: 99%
“…Therapeutic modalities include the use of vault brachytherapy (vaginal cylinders), standard external pelvic and/or extended field irradiation and intensity modulated radiotherapy. The incidence of major complications after radiotherapy approaches 4-5% and can be even higher following transperitoneal lymphadenectomies [6].…”
Section: Introductionmentioning
confidence: 99%