The Efficacy of Psychedelic-Assisted Therapy in Managing Post-traumatic Stress Disorder (PTSD): A New Frontier?

Mohamed, Arafath; Touheed, Shehla; Ahmed, Muhammad Zaheer; Hor, Mosab; Fatima, Sara

doi:10.7759/cureus.30919

Cited by 6 publications

(3 citation statements)

References 64 publications

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“…In addition, naltrexone can be highly effective in reducing alcohol intake as well as combating non-suicidal self-injury and binge eating (200)(201)(202)(203)(204)(205)(206)(207)(208)(209)(210). Other novel approaches to consider, especially when treatment-refractory major depression is a focus, may include the use of newer psychopharmacologic agents, e.g., 5-HT4 receptor antagonists (211), combining other previously unused evidence-based psychotherapies and psychopharmacologic approaches (142, 212), adjunctive application of neuromodulation tools, such as repetitive transcranial magnetic stimulation (rTMS) (213, 214), deep TMS (215) or electroconvulsive therapy (ECT) (216), novel psychotropic-or psychedelic-assisted therapies, such as ketamine/esketamine, 3,4-methylenedioxymethamphetamine (MDMA), psilocybin, and ayahuasca (12,28,212,(217)(218)(219)(220)(221)(222)(223)(224)(225)(226)(227)(228)(229)(230)(231), as well as deep brain stimulation (DBS) (232-235), although many of these newer approaches continue to be preliminary, experimental and/or challenging to acquire.…”

Section: Nutritional Rehabilitationmentioning

confidence: 99%

The integrated treatment of eating disorders, posttraumatic stress disorder, and psychiatric comorbidity: a commentary on the evolution of principles and guidelines

Brewerton

2023

Front. Psychiatry

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Psychiatric comorbidity is the norm in the assessment and treatment of eating disorders (EDs), and traumatic events and lifetime PTSD are often major drivers of these challenging complexities. Given that trauma, PTSD, and psychiatric comorbidity significantly influence ED outcomes, it is imperative that these problems be appropriately addressed in ED practice guidelines. The presence of associated psychiatric comorbidity is noted in some but not all sets of existing guidelines, but they mostly do little to address the problem other than referring to independent guidelines for other disorders. This disconnect perpetuates a “silo effect,” in which each set of guidelines do not address the complexity of the other comorbidities. Although there are several published practice guidelines for the treatment of EDs, and likewise, there are several published practice guidelines for the treatment of PTSD, none of them specifically address ED + PTSD. The result is a lack of integration between ED and PTSD treatment providers, which often leads to fragmented, incomplete, uncoordinated and ineffective care of severely ill patients with ED + PTSD. This situation can inadvertently promote chronicity and multimorbidity and may be particularly relevant for patients treated in higher levels of care, where prevalence rates of concurrent PTSD reach as high as 50% with many more having subthreshold PTSD. Although there has been some progress in the recognition and treatment of ED + PTSD, recommendations for treating this common comorbidity remain undeveloped, particularly when there are other co-occurring psychiatric disorders, such as mood, anxiety, dissociative, substance use, impulse control, obsessive–compulsive, attention-deficit hyperactivity, and personality disorders, all of which may also be trauma-related. In this commentary, guidelines for assessing and treating patients with ED + PTSD and related comorbidity are critically reviewed. An integrated set of principles used in treatment planning of PTSD and trauma-related disorders is recommended in the context of intensive ED therapy. These principles and strategies are borrowed from several relevant evidence-based approaches. Evidence suggests that continuing with traditional single-disorder focused, sequential treatment models that do not prioritize integrated, trauma-focused treatment approaches are short-sighted and often inadvertently perpetuate this dangerous multimorbidity. Future ED practice guidelines would do well to address concurrent illness in more depth.

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Section: Nutritional Rehabilitationmentioning

confidence: 99%

The integrated treatment of eating disorders, posttraumatic stress disorder, and psychiatric comorbidity: a commentary on the evolution of principles and guidelines

Brewerton

2023

Front. Psychiatry

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“…While large-scale clinical trials to evaluate the safety and efficacy of cannabis use are lacking (Tibbo et al, 2021), a systematic review showed that cannabis and synthetic cannabinoids may have a role in the treatment of PTSD. Similarly, prior research has demonstrated that psychedelic-assisted therapy can benefit people who experienced trauma (Mohamed, Touheed, Ahmed, Hor, & Fatima, 2022). To our knowledge, only one study has focused on using psychedelics in PTSD treatment for first responders.…”

Section: Discussionmentioning

confidence: 99%

Are first responders interested in psychedelics? Assessing previous use, interest, and willingness to participate in psychedelic-assisted therapy

Brodie,

Stunden,

Olson

et al. 2024

JPS

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Background and aimsFirst responders such as firefighters and police officers often experience traumatic events as part of their work. As a result, they are more likely to have mental health issues such as post-traumatic stress disorder, depression, and anxiety compared to the general population. Psychedelic-assisted therapy has emerged as a promising avenue to alleviate these issues, but little is currently known about first responders' interest in, and barriers to, these treatments. Here, we aimed to document first responders' attitudes towards LSD-assisted therapy and previous use of psychoactive drugs.MethodsWe recruited 102 participants through mailing lists of first responders' unions. Respondents were typically male firefighters in western Canada; others were police officers, paramedics, and military personnel across Canada and the United States. They were asked about their attitudes towards LSD- and marijuana-assisted therapies, previous psychiatric diagnoses, psychosocial impairments, and substance use.ResultsRespondents showed higher rates of distress and illicit drug use compared to the general population. Of those who sought professional treatment, a minority reported that the treatment had helped them. The respondents were generally interested in taking part in therapy or research involving LSD or marijuana. The setting (e.g., at home vs. a clinic), therapist presence, and drug dose were commonly reported to influence this participation.ConclusionsFirst responders may particularly benefit from psychedelic therapy given their high interest in psychedelic drugs and high rates of treatment-relevant disorders. Better understanding the needs of this population will help inform future clinical trials and psychedelic therapies.

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“…Zarzutem wobec stosowania substancji psychodelicznych w leczeniu zaburzeń psychicznych, w tym PTSD, jest ich potencjalna neurotoksyczność i zwiększone ryzyko późniejszego nadużywania substancji podawanych w trakcie terapii. Lecz biorąc pod uwagę rosnące zainteresowanie badawcze tym kierunkiem leczenia, wynikające z obiecujących wstępnych wyników, niewątpliwie terapia PTSD wspomagana psychodelikami stanowi obszar wymagający pogłębionej analizy [78].…”

Section: Substancje Psychodeliczne W Leczeniu Ptsdunclassified

The position statement of the Working Group on the treatment of post-traumatic stress disorders in adults

Koweszko,

de Barbaro,

Izydorczyk

et al. 2023

Psychiatr Pol

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Zespół stresu pourazowego (ang. post-traumatic stress disorder, PTSD) to zaburzenie psychiczne występujące po udziale w traumatycznym wydarzeniu, takim jak doświadczenie klęski żywiołowej, udział w wypadku, zamach terrorystyczny lub konflikt zbrojny, bycie ofiarą gwałtu, tortur lub przemocy fizycznej, doznanie urazu lub znalezienie się w innej sytuacji niosącej wysokie ryzyko utraty życia. Ofiara traumy nie zawsze musi być w pozycji osoby bezpośrednio zagrożonej fizyczną krzywdą. Zaburzenie może rozwinąć się także na skutek ostrej reakcji na stres spowodowanej udziałem w sytuacji, w której to inny człowiek doznaje cierpienia na tyle niewyobrażalnego, że dalsze normalne życie świadka staje się niemożliwe. Chorzy często są przekonani, że bezpowrotnie utracili zdolność wcześniejszej egzystencji. W skali globalnej zespół stresu pourazowego stanowi coraz częściej rozpoznawane zaburzenie. Można przewidywać, że w Europie w związku z trwającą wojną na Ukrainie oraz kryzysem migracyjnym częstość występowania ciężkich zaburzeń związanych ze stresem traumatycznym będzie systematycznie rosła. Na przestrzeni ostatnich lat nastąpił znaczny postęp wiedzy i rozwoju metod służących przeciwdziałaniu PTSD. Potwierdzone empirycznie formy leczenia obejmują oddziaływania psychoterapeutyczne i farmakoterapeutyczne. Zaproponowane rekomendacje zostały opracowane przez zespół ekspertów z obszaru psychiatrii, psychologii klinicznej, psychoterapii i medycyny rodzinnej w celu przedstawienia wytycznych dotyczących postępowania terapeutycznego w praktyce lekarskiej i psychologicznej. Stanowisko grupy roboczej zostało opracowane zgodnie z wiedzą opartą na dowodach (evidence-based practice) w ramach trzyetapowego postępowania obejmującego: przegląd literatury, dyskusję dotyczącą zagadnienia oraz wypracowanie wspólnego stanowiska eksperckiego.

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The Efficacy of Psychedelic-Assisted Therapy in Managing Post-traumatic Stress Disorder (PTSD): A New Frontier?

Cited by 6 publications

References 64 publications

The integrated treatment of eating disorders, posttraumatic stress disorder, and psychiatric comorbidity: a commentary on the evolution of principles and guidelines

The integrated treatment of eating disorders, posttraumatic stress disorder, and psychiatric comorbidity: a commentary on the evolution of principles and guidelines

Are first responders interested in psychedelics? Assessing previous use, interest, and willingness to participate in psychedelic-assisted therapy

The position statement of the Working Group on the treatment of post-traumatic stress disorders in adults

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