The efficacy of resin infiltrant and casein phosphopeptide–amorphous calcium fluoride phosphate in treatment of white spot lesions (comparative study)

Abstract

A BSTRACT Background: White spot lesions (WSLs) are considered as the first sign of the progression of dental caries that can be reversed. Casein phosphopeptide–amorphous calcium fluoride phosphate (CPP-ACFP) varnish can promote remineralization process of the demineralized tooth structure. Also, WSLs can be managed by using caries infiltrant (ICON), which infiltrates etched enamel surface of the WSLs. Objectives: The main aim was to evaluate and compare the efficacy of ICON versus CPP-ACFP varnish to treat WSLs in the same oral environments. Materials and Methods: A total of 30 participants aged 20–40 years with at least two WSLs have participated in this trial. Split-mouth technique has been used in this trial where WSLs on the left side have been treated with ICON, whereas WSLs on the right side have been treated with CPP-ACFP varnish. Clinical evaluation using DIAGNOdent was carried out at baseline, 1 week, 1, 3, 6, and 12 months after application to determine the effectiveness of these materials in treating WSLs. Results: Significant differences were observed between all follow-up DIAGNOdent scores compared to baseline readings of both ICON and CPP-ACFP ( P = 0.000 for all comparisons). Statistically significant differences were observed between DIAGNOdent scores of ICON compared to CPP-ACFP at all follow-up intervals ( P = 0.006, 0.008, 0.045, 0.036, and 0.000). Conclusion: Both ICON and CPP-ACFP were effective in the treatment of WSLs of smooth surfaces but the efficacy of CPP-ACFP was better than ICON.

Roughness and Microhardness of Demineralized Enamel Treated with Resinous Infiltrants and Subjected to an Acid Challenge: An in vitro Study

“…Then, after exposure to pH cycling of the infiltrated samples, the microhardness values were even lower for both the EI and CI, with no statistical difference between them; however, the two groups of infiltrants exhibited a statistically significant difference in terms of microhardness recorded, shortly after they were infiltrated into the white spot lesions. This may have been associated with the degradation and dissolution of the resin material in an aqueous medium after the periods of pH cycling [34]. The large quantity of monomer TEGDMA in the composition of resin infiltrants makes them highly hydrophilic; thus, they have less resistance to deterioration in aqueous media [32].…”

Eficácia do uso de infiltrantes em lesões de mancha branca com diferentes profundidades: uma revisão integrativa

“…A eficácia da resina de infiltração em comparação com outras técnicas de tratamento para lesões dentárias, notadamente manchas brancas e defeitos de esmalte, tem sido objeto de investigação em diversos estudos clínicos. O estudo conduzido por (Baafif et al, 2020) abordou a comparação entre resina de infiltração e um composto à base de caseína fosfopeptídeo-fluoreto de cálcio amorfo. A análise não se restringiu apenas à eficácia imediata, mas incorporou a estabilidade a longo prazo dos resultados e a preferência do paciente quanto à aplicação do tratamento.…”

“…Não obstante, a eficácia em diferentes profundidades dentárias é uma consideração premente na seleção de tratamentos. O estudo de (Baafif et al, 2020) não revelou diferenças significativas na profundidade das lesões tratadas entre resina de infiltração e o composto de caseína estudado. Tal constatação é congruente com as descobertas de (Gençer & Kirzioğlu, 2019), que destacaram a eficácia da resina de infiltração em lesões de esmalte em várias profundidades, consolidando, assim, a adaptabilidade dessa técnica a diferentes contextos clínicos.…”

“…(Sezici et al, 2020) Estudo in vivo Avaliar a eficácia da infiltração de resina fotopolimerizável de baixa viscosidade em lesões de mancha branca pós-ortodôntica em lesões incipientes e avançadas usando fluorescência quantitativa induzida por luz A infiltração de rea de baixa viscosidade melhora a perda de fluorescência, a área da lesão e o impacto em lesões incipientes e avançadas. (Baafif et al, 2020)…”

An in vitro study to evaluate and compare the remineralizing potential among Casein Phosphopeptide-amorphous Calcium Phosphate (CPP-ACP) with fluoride and surface pre-reacted glass (S-PRG) fillers using quantitative analysis

“…The ability to release and recharge fluoride ions is acidity dependent, and under external force, these carious lesions treated by S-PRG Fillers may collapse and lead to cavitation [15,16]. This could be the reason for the low level of remineralisation in the samples treated with S-PRG Fillers.…”