The efficacy of sarang semut extract (Myrmecodia pendens Merr & Perry) in inhibiting Porphyromonas gingivalis biofilm formation

Abstract

Background: Porphyromonas gingivalis (P. gingivalis) is a pathogenic bacteria present in the oral cavity involved in the pathogenesis

Antibacterial alternatives using the potential of the ant nest plant (Myrmecodia spp.)

“…Ant nest plants display antibacterial properties. Alibasyah et al [40] found that compounds derived from M. pendans ethyl acetate extract, specifically diterpenoids and biflavonoids, exhibit antibacterial properties against P. gingivalis, as determined by the Kirby-Bauer method. In the study, six iridoids showed antibacterial activity against S. aureus, each with a minimum inhibitory concentration (MIC) above 100 μg/mL, while the MICs for the other two were 19.57 and 39.06 μg/mL.…”

Medicinal Properties of Ant Nest Plant (Myrmecodia Genus): A Comprehensive Review

“…Several species of them have been successfully identified, M. pendens contained kaempferol, luteolin, rutin, quercetin and apigenin, rosmarinic acid, procyanidin B1, the polymer of procyanidin B1, gallic acid, (+)-catechin, caffeic acid, p-coumaric acid, and ferulic acid [7], [31], [32]. Some researchers reported that phenolic glycoside with aliphatic moiety [13], dibenzo-p-dioxin-2,8-dicarboxylic acid [33], guaiacol, 1,4-di-tert-butoxybenzene, 4-methylcatechol and 2,6-dimethoxy-phenol [34], anthocyanin [35] and biflavonoid [36] have been isolated from M. pendens. Other isolates of flavonoid and phenolic compounds were found in M. platytyrea such as, acylated flavanone, flavanone (liquiritigenin or isoliquiritigenin), O-methylated isoflavone (calycosin) and 2-(2-methylbutyryl) phloroglucinol glucoside [37].…”

“…and Bacillus sp. [15], Candida albicans, Staphylococcus aureus [38], Streptococcus mutans [39], Shigella dysenteriae [40], Streptococcus sanguinis [41], [42], [43], Enterococcus faecalis [34], [44], Porphyromonas gingivalis [45] and Treponema denticola [42]. activity against P. gingivalis pathogen using Kirby-Bauer method with minimum inhibitory concentration (MIC) of 19.57 µg/mL and 39.06 µg/mL, respectively [36].…”

“…[15], Candida albicans, Staphylococcus aureus [38], Streptococcus mutans [39], Shigella dysenteriae [40], Streptococcus sanguinis [41], [42], [43], Enterococcus faecalis [34], [44], Porphyromonas gingivalis [45] and Treponema denticola [42]. activity against P. gingivalis pathogen using Kirby-Bauer method with minimum inhibitory concentration (MIC) of 19.57 µg/mL and 39.06 µg/mL, respectively [36]. Six compounds phenolic and terpenoid group have been found in M. pendens and some of them gave antibacterial activity by Kirby-Bauer method with the inhibition zone of isolates at concentration of 5000 µg/mL, such as dibenzo-p-dioxin-2,8-dicarboxylic acid against E. faecalis (8.55 mm), stigmast-4-ene-3-one and pomolic acid against S. mutans were 9.00 mm and 10.24 mm respectively and phloroglucinol sesquiterpene against P. gingivalis (12.31 mm).…”

Effect of Purple Leaf Extract (Graptophyllum Pictum (L.) Griff) on the Number of Macrophage Cells in Pulp Perforation

“…Mechanical trauma to the pulp treatment procedure cannot be avoided especially if caries expand to deep depths. The action of cavity preparation or removal of carious tissue in deep cavities can cause pulp perforation 1 . Pulp perforation can be caused by the use of burs or other dental tools.…”