The Efficacy of Serum Carcinoembryonic Antigen (CEA), Cancer Antigen 125 (CA125), Carbohydrate Antigen 19-9 (CA19-9), Carbohydrate Antigen 15-3 (CA15-3), α-Fetoprotein (AFP) and Human Chorionic Gonadotropin (hCG) Levels in Determining the Malignancy of Solitary Pulmonary Nodules

Bekci, TT; Şenol, Taylan; Maden, Emin

doi:10.1177/147323000903700219

Cited by 21 publications

(11 citation statements)

References 14 publications

(16 reference statements)

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“…In addition, the diagnostic performance of the combination panel of miR-148/152 family (AUC, 0.789) was significantly higher than that of CEA (AUC, 0.506). As a widely used diagnostic biomarker for NSCLC patients, CEA is found to confer good specificity but relatively poor sensitivity for the diagnosis of NSCLC [ 13 ]. In addition to having a higher diagnostic value, the sensitivity of the miR-148/152 family panel was also higher (72.2%) than that of CEA.…”

Section: Discussionmentioning

confidence: 99%

Expression of miR-148/152 Family as Potential Biomarkers in Non-Small-Cell Lung Cancer

Chen

et al. 2015

Med Sci Monit

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BackgroundAltered miR-148/152 family expression contributes to human carcinogenesis. This study was designed to detect the potential for using miR-148/152 family as biomarkers for NSCLC patients.Material/MethodsThe relative expression levels of miR-148/152 family (miR-148a, miR-148b, and miR-152) in serum of 36 non-small-cell lung carcinoma (NSCLC) patients, 20 patients with benign pulmonary diseases (BPD), and 10 healthy individuals were assessed by real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR).ResultsThe expression of all three miRNAs were significantly lower in the serum of NSCLC than that of BPD and healthy controls (all p<0.01), and their expression levels were strongly correlated with each other (r=0.781, 0.720, and 0.645, respectively). Downregulation of miR-148/152 family was found to be corrected with more aggressive tumors. The area under the receiver operating characteristic curves (AUCs) for miR-148a, miR-148b, and miR-152 discriminating NSCLC from BPD were 0.775, 0.725, and 0.774, respectively, all higher than that of CEA (0.506). Combining the three miRNAs increased the discrimination performance, yielding an AUC of 0.789 (95% confidence interval, 0.643 to 0.895), with a sensitivity of 72.2% and a specificity of 90.0%.ConclusionsThe results of present study suggest that the expression levels of circulating miR-148/152 family may serve as biomarkers for NSCLC.

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Section: Discussionmentioning

confidence: 99%

Expression of miR-148/152 Family as Potential Biomarkers in Non-Small-Cell Lung Cancer

Chen

et al. 2015

Med Sci Monit

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“…In the Swensen model, factors such as age, smoking history, history of other cancers, diameter, spiculation, and location of the nodules have important significance in judging between benign and malignant nodules [15]. We found that age, smoking history, emphysema, diameter, spiculation, and vascular sign have statistical significance in differentiating benign and malignant nodules.…”

Section: Discussionmentioning

confidence: 97%

Combining serum miRNAs, CEA, and CYFRA21-1 with imaging and clinical features to distinguish benign and malignant pulmonary nodules: a pilot study

Zhang

Jin

et al. 2017

World J Surg Onc

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BackgroundOur study was designed to improve the accuracy of determining whether pulmonary nodules are benign or malignant.MethodsWe evaluated the clinical and imaging features and serum markers: neuron specific enolase (NSE), carcino-embryonic antigen (CEA), cytokeratin fragment antigen 21–1 (CYFRA 21–1), miRNA-21-5p, and miR-574-5pof in 39 patients with pathology information. Factors that differed significantly between those with benign versus malignant pulmonary nodules were used to establish a prediction model for identifying malignant nodules.ResultsThe studied nodules were 51.3% malignant and 48.7% benign. Age, smoking status, nodule diameter, history of emphysema, vascular sign, burr sign, CYFRA21-1, CEA, miRNA-21-5p, and miRNA-574-5p differed significantly between the benign and malignant nodule groups. Serum levels of CYRFA21-1 and CEA could be used to distinguish between malignant and benign nodules with a positive predictive value (PPV) of 80.0%, a negative predictive value (NPV) of 84.2%, and an area under the receiver operating characteristics curve (AUC) of 0.863. Using the serum levels of miRNA-21-5p and miRNA-574-5p, the PPV was 55%, the NPV was 84.2%, and the AUC was 0.797. When all four serum markers were combined, the PPV was 80%, the NPV was 89.5%, and the AUC was 0.921. We established a prediction model for malignant nodules, including clinical features, imaging features, and serum markers. In cross-validation, the ratio of discriminant conformance was 95%.ConclusionsSerum levels of miRNA-21-5p and miRNA-574-5p are significantly higher in patients with malignant nodules than in patients with benign nodules and are potential serum biomarkers. Our prediction model could improve malignant nodule diagnosis.

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“…The diagnosis of malignant SPN remains a clinical challenge at present. Although numerous studies have demonstrated that multiple serum biomarkers, including CEA, cytokeratin 19 fragment and CA125, are elevated in malignant SPN, the diagnostic performance of these biomarkers alone is not sufficient for clinical application. We describe, for the first time, measurement of serum MIC‐1 expression from malignant SPN patients, and benign SPN patients including tuberculosis, pneumonia, and patients with hamartoma.…”

Section: Discussionmentioning

confidence: 99%

The value of macrophage inhibitory cytokine‐1 level in differentiating benign from malignant solitary pulmonary nodules

Xue

Zhang

et al. 2017

Clinical Respiratory J

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The Efficacy of Serum Carcinoembryonic Antigen (CEA), Cancer Antigen 125 (CA125), Carbohydrate Antigen 19-9 (CA19-9), Carbohydrate Antigen 15-3 (CA15-3), α-Fetoprotein (AFP) and Human Chorionic Gonadotropin (hCG) Levels in Determining the Malignancy of Solitary Pulmonary Nodules

Cited by 21 publications

References 14 publications

Expression of miR-148/152 Family as Potential Biomarkers in Non-Small-Cell Lung Cancer

Expression of miR-148/152 Family as Potential Biomarkers in Non-Small-Cell Lung Cancer

Combining serum miRNAs, CEA, and CYFRA21-1 with imaging and clinical features to distinguish benign and malignant pulmonary nodules: a pilot study

The value of macrophage inhibitory cytokine‐1 level in differentiating benign from malignant solitary pulmonary nodules

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