The efficacy of speed of processing training for improving processing speed in individuals with multiple sclerosis: a randomized clinical trial

Chiaravalloti, Nancy D.; Costa, Silvana L.; Moore, Nancy B.; Costanza, Kristen; DeLuca, John

doi:10.1007/s00415-022-10980-9

“…FDA-approved dementia medications donepezil and memantine failed to reduce cognitive dysfunction in MS trials [4,5]. The popular supplements gingko biloba and vitamin D similarly failed in clinical trials for that purpose [6,7]. Cognitive behavioral therapy can improve processing speed dysfunction in people with MS, but suffers from limited access due to factors like proximity to services, health insurance coverage, and time required to participate [8].…”

Section: Introductionmentioning

confidence: 99%

Centella asiatica promotes antioxidant gene expression and mitochondrial oxidative respiration in experimental autoimmune encephalomyelitis

Kundu,

Yasuhara,

Brandes

et al. 2023

Preprint

0

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Centella asiatica (Centella) is a traditional botanical medicine that shows promise in treating dementia based on behavioral alterations seen in animal models of aging and cognitive dysfunction. In order to determine if Centella could similarly improve cognitive function and reduce disease burden in multiple sclerosis (MS), we tested its effects in the neuroinflammatory experimental autoimmune encephalomyelitis (EAE) model of MS. In two independent experiments, C57BL/6J mice were treated following induction of EAE with either a standardized water extract of Centella (CAW) or placebo for 2 weeks. At the dosing schedule and concentrations tested, CAW did not improve behavioral performance, EAE motor disability, or degrees of demyelination. However, CAW-treated mice demonstrated increases in nuclear factor (erythroid-derived 2)-like 2 and other antioxidant response element genes, and increases in mitochondrial respiratory activity. Caw also decreased spinal cord inflammation. Our findings indicate that CAW can increase antioxidant gene expression and mitochondrial respiratory activity in mice with EAE, supporting investigation of the clinical effects of CAW in people with MS.

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“…FDA-approved dementia medications donepezil and 2 memantine failed to reduce cognitive dysfunction in MS trials [4,5]. Cognitive behavioral therapy can improve processing speed dysfunction in people with MS, but suffers from limited access [6].…”

Section: Introductionmentioning

confidence: 99%

Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis

Kundu,

Yasuhara,

Brandes

et al. 2023

Preprint

0

View full text Add to dashboard Cite

Centella asiatica (Centella) is a traditional botanical medicine that shows promise in treating dementia based on behavioral alterations seen in animal models of aging and cognitive dysfunction. In order to determine if Centella could similarly improve cognitive function and reduce disease burden in multiple sclerosis (MS), we tested its effects in the neuroinflammatory experimental autoimmune encephalomyelitis (EAE) model of MS. In two independent experiments, C57BL/6J mice were treated following induction of EAE with either a standardized water extract of Centella (CAW) or placebo for 2 weeks. At the dosing schedule and concentrations tested, CAW did not improve behavioral performance, EAE motor disability, or degrees of demyelination. However, CAW-treated mice demonstrated increases in nuclear factor (erythroid-derived 2)-like 2 and other antioxidant response element genes, and increases in mitochondrial respiratory activity. Caw also decreased spinal cord inflammation. Our findings indicate that CAW can increase antioxidant gene expression and mitochondrial respiratory activity in mice with EAE, supporting investigation of the clinical effects of CAW in people with MS.

show abstract

The Efficacy of the Speed of Processing Training Program in Improving Functional Outcome: From Restoration to Generalization

Goverover

¹

,

Costa

²

,

DeLuca

³

et al. 2023

Archives of Physical Medicine and Rehabilitation

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0

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The efficacy of speed of processing training for improving processing speed in individuals with multiple sclerosis: a randomized clinical trial

Cited by 8 publications

References 48 publications

Centella asiatica promotes antioxidant gene expression and mitochondrial oxidative respiration in experimental autoimmune encephalomyelitis

Centella asiatica promotes antioxidant gene expression and mitochondrial oxidative respiration in experimental autoimmune encephalomyelitis

Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis

The Efficacy of the Speed of Processing Training Program in Improving Functional Outcome: From Restoration to Generalization

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