The efficacy of subthreshold micropulse yellow laser (577 nm) in chronic central serous chorioretinopathy

Uzlu, Dilek; Erdöl, Hidayet; Kola, Mehmet; OZBAY, Ahmet Duhan

doi:10.1007/s10103-020-03129-5

Cited by 16 publications

(11 citation statements)

References 30 publications

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“…Sublethal RPE hyperthermia has been shown to activate different intracellular molecules, such as heat shock protein 70 [ 13 , 14 , 15 ] and water transport protein aquaporine [ 16 ]. Furthermore, it has been shown to increase the antioxidative potential [ 17 , 18 ] and to reduce the thickness of the Bruch’s membrane in an age-related macular degeneration (AMD) mice model [ 19 , 20 , 21 , 22 ]. Thus, sublethal RPE thermal treatment gained increasing attention as a new therapeutic option for different macular disorders, such as CSC, diabetic macular edema and AMD [ 20 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, it has been shown to increase the antioxidative potential [ 17 , 18 ] and to reduce the thickness of the Bruch’s membrane in an age-related macular degeneration (AMD) mice model [ 19 , 20 , 21 , 22 ]. Thus, sublethal RPE thermal treatment gained increasing attention as a new therapeutic option for different macular disorders, such as CSC, diabetic macular edema and AMD [ 20 , 23 ]. In particular, the PLACE trial and a recent meta-analysis demonstrated that SML may be considered as a competitive alternative to PDT for treating chronic CSC, and as the first-line treatment of chronic CSC [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study

Prasuhn

Miura

Tura

et al. 2021

JCM

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Background: Central serous chorioretinopathy (CSC) is a common macular condition characterized by detachment of the neuroretina and is a frequent cause of central vision loss in adults. Among the various therapeutic strategies, subthreshold microsecond pulsed laser (SML) treatment has become a useful option. Despite the suggested involvement of choroidal circulatory disturbances in CSC, the effects of this treatment on macular microperfusion have not been fully evaluated yet. Herein, we report the impact of SML on retinal and choroidal microvascular flow using non-invasive optical coherence tomography (OCT) angiography (OCTA). Methods: In this study, CSC patients with persistent subretinal fluid (SRF) with or without secondary choroidal neovascularization (CNV) were included (referred to as the pachychoroid neovasculopathy (PNV) group and the CSC group, respectively). SML was conducted using a yellow (577 nm) laser with a duty cycle of 10%, spot size of 200 µm and duration of 200 ms. Best corrected visual acuity (BCVA) as well as OCT and OCTA images were evaluated at baseline and 4 weeks after SML. OCTA parameters of interest included full retinal perfusion (FRP), choriocapillaris perfusion (CCP), Sattler’s layer perfusion (SLP), and Haller’s layer perfusion (HLP), which were evaluated longitudinally and compared to unaffected fellow eyes. Results: 27 affected eyes and 17 fellow eyes from 27 patients were included. Before treatment, central retinal thickness (CRT) and subfoveal choroidal thickness (SFCT) of affected eyes were significantly larger than in fellow eyes. Four weeks after SML, CRT decreased significantly, whereas perfusion parameters did not change. In subgroup analyses, the CSC group showed a significant decrease in SFCT, whereas the PNV group did not despite the decrease in CRT. Conclusion: Our results suggest that the SML may affect the SFCT of the CSC, but not the PNV patients at least within four weeks following treatment. This effect seems to be independent of the change in choroidal perfusion measured with OCTA.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study

Prasuhn

Miura

Tura

et al. 2021

JCM

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“…We noticed a significant reduction in CRT after SML (306 vs. 266µm; p=0.024). However, the BCVA and CRT outcome after SML usually change most over a longer period, which is not covered by our study design [7,20,31].…”

Section: Discussionmentioning

confidence: 99%

“…Sublethal RPE hyperthermia has been shown to activate different intracellular molecules, such as heat shock protein 70 [13][14][15] and water transport protein aquaporine [16]. Furthermore, it has been shown to increase the antioxidative potential [17,18] and to reduce the thickness of the Bruch's membrane in an age-related macular degeneration (AMD) mice model [19][20][21][22]. Thus, sublethal RPE thermal treatment gained increasing attention as a new therapeutic option for different macular disorders, such as CSC, diabetic macular edema and AMD [20].…”

Section: Introductionmentioning

confidence: 99%

“…Although there is an increasing clinical evidence in the treatment of CSC using SML [20], the effect of the treatment on the choroid has not been thoroughly investigated to date. Therefore, in the present study, we aimed to investigate structural and functional alterations of the retina and the choroidal sublayers in patients with CSC before and after SML using OCT and OCTA.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study

Prasuhn

Miura

Tura

et al. 2021

Preprint

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Background: Central serous chorioretinopathy (CSC) is a common macular condition characterized by detachment of the neuroretina and is a frequent cause of central vision loss in adults. Among the various therapeutic strategies, subthreshold microsecond pulsed laser (SML) treatment has become a useful option. Despite the suggested involvement of choroidal circulatory disturbances in CSC, effects of this treatment on macular microperfusion have not been fully evaluated yet. Herein, we report the impact of SML on retinal and choroidal microvascular flow using non-invasive optical coherence tomography (OCT) angiography (OCTA). Methods: In this study, CSC patients with persistent subretinal fluid (SRF) with or without secondary choroidal neovascularization (CNV) were included (referred to as pachychoroid neovasculopathy (PNV) group and CSC group, respectively). SML was conducted using a yellow (577 nm) laser with duty cycle of 10%, spot size of 200 µm and duration of 200 ms. Best corrected visual acuity (BCVA) as well as OCT and OCTA images were evaluated at baseline and 4 weeks after SML. OCTA parameters of interest included full retinal perfusion (FRP), choriocapillaris perfusion (CCP), Sattler’s layer perfusion (SLP), and Haller’s layer perfusion (HLP), which were evaluated longitudinally and compared to unaffected fellow eyes. Results: 27 affected eyes and 17 fellow eyes from 27 patients were included. Before treatment, central retinal thickness (CRT) and subfoveal choroidal thickness (SFCT) of affected eyes were significantly larger than in fellow eyes. Four weeks after SML, CRT decreased significantly, whereas perfusion parameters did not change. In subgroup analyses, the CSC group showed a significant decrease of SFCT, whereas the PNV group did not despite the decrease of CRT. Conclusion: Our results suggest that the SML may SFCT of CSC, but not of PNV patients at least within four weeks following treatment. This effect seems to be independent of the change in choroidal perfusion measured with OCTA.

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The effect of nondamaging subthreshold laser therapy in patients with chronic central serous chorioretinopathy

Lee,

Kim

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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The efficacy of subthreshold micropulse yellow laser (577 nm) in chronic central serous chorioretinopathy

Cited by 16 publications

References 30 publications

Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study

Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study

Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study

The effect of nondamaging subthreshold laser therapy in patients with chronic central serous chorioretinopathy

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