The efficacy of supplemental magnesium in reducing atrial fibrillation after coronary artery bypass grafting

Hazelrigg, Stephen R.; Boley, Theresa M.; Cetindag, Ibrahim B.; Moulton, Kreigh P.; Trammell, Gary L.; Polancic, Joan; Shawgo, Tilitha; Quin, Jacquelyn A.; Verhulst, Stephen

doi:10.1016/j.athoracsur.2003.08.027

Cited by 45 publications

(26 citation statements)

References 19 publications

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“…This drug reduced the incidence of AF in 29% and of ventricular arrhythmia in 48% however, it did not reduce the time of hospitalization, the incidence of myocardial infarction or the mortality rate [11]. Another randomized study of 202 patients also concluded that the prophylactic administration of magnesium did not benefit patients sufficiently to recommend its routine utilization in heart surgeries [12].…”

Section: Discussionmentioning

confidence: 99%

Efeito da denervação cardíaca ventral na incidência de fibrilação atrial após revascularização cirúrgica do miocárdio

Breda¹,

Breda²,

Freitas³

et al. 2008

Rev Bras Cir Cardiovasc

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Objective: To evaluate the effect of ventral cardiac denervation on the incidence of atrial fibrillation after coronary artery bypass grafting.Methods: Between September and November 2005, 50 patients from the same institution, without previous diagnosis of atrial arrhythmia, presenting with coronary heart disease with indication for coronary artery bypass grafting were enrolled in a prospective, randomized study. The exclusion criteria were: patients older than 75 years of age, previous history of atrial arrhythmia and associated heart surgeries. Denervation was performed before cardiopulmonary bypass by removing the adipose tissues around the superior vena cava, aorta and pulmonary artery. Patients submitted to denervation were compared with a control group regarding demographic, clinical and operative variables.

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Section: Discussionmentioning

confidence: 99%

Efeito da denervação cardíaca ventral na incidência de fibrilação atrial após revascularização cirúrgica do miocárdio

Breda¹,

Breda²,

Freitas³

et al. 2008

Rev Bras Cir Cardiovasc

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“…Many authors have described the intravenous Mg infusion as a good method to correct hypomagnesaemia [10,[14][15][16]. Fanning et al [17] reported that the infusion of magnesium sulphate at the dose of 84 mmol/96 h reduced AF from 28% to 14.3% [17]; however, the decline was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Prophylactic Magnesium and Rhythm Disorders after Open Cardiac Surgery

Abbas

Khan

Abbas

et al. 2015

JCCR

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Objective: To evaluate the effect of intravenous magnesium, on prevention of postoperative cardiac arrhythmias after open cardiac surgery.Methodology: Prospective interventional study was conducted at Department Of Cardiac Surgery Punjab Institute Of Cardiology, Lahore from 1 st August 2011 to 31 st March 2012. Study groups included 260 consecutive patients undergoing CABG having normal sinus rhythm. They were classified as group I receiving magnesium supplementation perioperatively & group II not receiving magnesium supplementation. Intravenous Magnesium was administered before weaning from CPB and on 1 st postoperative day. Twelve-lead electrocardiograms were obtained immediately after operation and daily until detection of new onset arrhythmias. The distribution of both groups in CABG patients was compared for rhythm disorders. Results:The mean age of patients was 51.73±10.16 years. A total of 41 patients developed arrhythmias postoperatively. There was no mortality during the study in that specific group. Other analysis indicates there is an effect of intravenous Mg on the prevention of post cardiac arrhythmia after open heart surgery. Conclusion:Prophylactic administration of intravenous magnesium is associated with low incidence of postoperative cardiac arrhythmias.

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“…[18][19][20][21] However, several of these studies were limited by small sample size, improper blinding, and the use of a lower dose of Mg than in the current study. In fact, by combining studies on Mg prophylaxis in CABG surgery that were properly blinded and with sufficient patient sample sizes, Hazelrigg et al 34 failed to find an overall reduction in postoperative atrial or ventricular arrhythmias. Cook et al 35 were also unable to demonstrate a difference in the rate of clinically important atrial arrhythmia in patients receiving Mg versus placebo in addition to routine beta-blockade.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative Magnesium Administration Does Not Reduce Postoperative Atrial Fibrillation After Cardiac Surgery

Klinger

Thunberg

White

et al. 2016

Survey of Anesthesiology

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Background-Hypomagnesemia has been associated with an increased risk of postoperative atrial fibrillation (POAF). While earlier studies have suggested a beneficial effect of magnesium (Mg) therapy, almost all of these are limited by small sample size and relatively low Mg dose. We hypothesized that high-dose Mg decreases the occurrence of new-onset POAF, and we tested this hypothesis using data from a prospective trial assessing the effect of Mg on cognitive outcomes in cardiac surgical patients.

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The efficacy of supplemental magnesium in reducing atrial fibrillation after coronary artery bypass grafting

Cited by 45 publications

References 19 publications

Efeito da denervação cardíaca ventral na incidência de fibrilação atrial após revascularização cirúrgica do miocárdio

Efeito da denervação cardíaca ventral na incidência de fibrilação atrial após revascularização cirúrgica do miocárdio

Prophylactic Magnesium and Rhythm Disorders after Open Cardiac Surgery

Intraoperative Magnesium Administration Does Not Reduce Postoperative Atrial Fibrillation After Cardiac Surgery

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