The Efficacy of Systemic Doxycycline Administration as an Inhibitor of Intimal Hyperplasia after Balloon Angioplasty Arterial Injury

Mountain, Deidra J.H.; Kirkpatrick, Stacy S.; Arnold, Joshua D.; Buckley, Michael R.; McNally, Michael M.; Stevens, Scott L.; Freeman, Michael B.; Grandas, Oscar H.

doi:10.1016/j.avsg.2018.11.005

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…20 Regarding the exclusive usage of either balloon angioplasty or BMS implantation in carotid artery stenosis, numerous experimental studies have been conducted to assess the preventive impact of a wide variety of pharmaceutical agents on neointimal hyperplasia in the context of post-balloon angioplasty or ISR or IST in carotid arteries. [21][22][23] However, no firm conclusions have been drawn. On the other hand, a plethora of evidence have indicated dual antiplatelet therapy as an effective measure to reduce ISR or IST in patients undergoing coronary stenting, even in the long term.…”

Section: Discussionmentioning

confidence: 99%

Carotid Stent Restenosis and Thrombosis in Rabbits: The Effect of Antiplatelet Agents

Kadoglou

Stasinopoulou

Giannakopoulos

et al. 2020

J Cardiovasc Pharmacol Ther

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Background: The purpose of the study was the comparative assessment of ticagrelor and clopidogrel effects on carotid post-balloon injury (PBI) and on post carotid artery stenting (CAS) rate of in-stent restenosis (ISR) and in-stent thrombosis in atherosclerotic rabbits. Methods: Forty-eight New Zealand white rabbits on high-fat diet were randomized into 4 groups: A1: PBI and clopidogrel (30 mg/kg/d), A2: PBI and ticagrelor (21 mg/kg twice daily), B1: PBI, CAS, and clopidogrel (30 mg/kg/d), B2: PBI, CAS, and ticagrelor (21 mg/kg twice daily). All rabbits received orally aspirin (10 mg/kg/d) and interventions were performed in their right carotid arteries (RCAs). Optical coherence tomography (OCT) and carotid angiography were performed at end point, while platelet aggregation and lipid profile were measured. After euthanasia both carotids were obtained for histological examination. Results: In B1 group, 3 rabbits presented thrombotic total occlusion of the stents, while none such episode was observed in B2 group. The neointimal areas in RCAs, calculated by OCT, did not differ between A1 and A2 groups, and between B1 and B2 groups ( P > .05). From the histological findings, the intima/(media + intima) percentage (%) in RCAs of balloon-injured rabbits did not present any difference between groups ( P = .812). Similarly, the immunohistochemically determined accumulation of endothelial cells and macrophages on vascular walls was equivalent between groups ( P > .05). Conclusion: Following carotid balloon injury and stenting, clopidogrel and ticagrelor did not show any differential effects on the extent of neointimal formation and ISR in atherosclerotic rabbits receiving aspirin. Three thrombotic stent occlusions were noted in the clopidogrel treatment group, but this finding was not statistically significant.

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Section: Discussionmentioning

confidence: 99%

Carotid Stent Restenosis and Thrombosis in Rabbits: The Effect of Antiplatelet Agents

Kadoglou

Stasinopoulou

Giannakopoulos

et al. 2020

J Cardiovasc Pharmacol Ther

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“…69 However, in an in-vivo rodent model of vascular injury, systemic doxycycline administration before or at the time of vascular injury does not significantly reduce the progress of intimal hyperplasia. 70 HMG-CoA reductase inhibitors, widely known as statins, have also been consistently shown to possess a matrix-stabilising effect, through MMPs and TIMPs modulation. 71 This is partially related to the ability of statins to inhibit the isoprenylation of signalling proteins, resulting in modification of proinflammatory and proatherogenic genes.…”

Section: Future Research Areamentioning

confidence: 99%

A Review on the Relationship between Matrix Metalloproteinases (Mmps) and their Natural Inhibitors (Tissue Inhibitors Of Matrix Metalloproteinases [Timps]) and the Success of an Autologous Arteriovenous Fistula (Avf)

Rahman

Othman

2021

imjm

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Since its introduction by Brescia and Cimino in 1966, arteriovenous fistula has been regarded as the best vascular access for haemodialysis purpose. However, it’s not without any drawbacks which has cost over USD1 billion in the United States alone to rectify them. Intimal hyperplasia has been shown to be a major contributory factor to this development. Intimal hyperplasia is a complex molecular process resulting in unwarranted accumulation of contractile smooth muscle cells, myofibroblasts, fibroblasts, and macrophages. There is an increasing amount of evidence suggesting that matrix metalloproteinases (MMPs) and its natural inhibitors (tissue inhibitors of matrix metalloproteinases ([TIMPs]) play a pivotal role in the development of intimal hyperplasia. Our purpose of writing this review article is to examine these evidences and to suggest of what future research questions need to be answered to further strengthen and clarify this relationship.

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“…Doxycycline has shown to be a powerful MMPs inhibitor also it suppresses in vitro migration of vascular smooth muscle cells [27]. Doxycycline also modulates many cellular functions such as cellular proliferation and matrix remodeling [28].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of doxycycline as a combination therapy in the treatment of rheumatoid arthritis: a randomized controlled clinical trial

et al. 2021

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Background This single-center randomized open-label clinical trial evaluates the effectiveness of doxycycline as a combination therapy for active rheumatoid arthritis (RA) with methotrexate (MTX). Materials and methods One hundred and sixty RA patients were recruited who fulfilled the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria. Subjects were randomly allocated in a 1:1 ratio into one of two treatment arms; one group was maintained on MTX alone and the other group on MTX together with doxycycline orally 200 mg daily. Follow-up clinical response, erythrocyte sedimentation rate (ESR), levels of C-reactive protein (CRP), and disease activity score 28 (DAS28-CRP) after 3 months were done. Results There was a significant difference regarding DAS28-CRP between the two groups (median (IQR) 4.26 (3.6–5) for those treated with MTX alone compared with 2.8 (2.37–3.5) for those treated with MTX together with doxycycline) (p = 0.005). A higher number of patients treated with doxycycline in combination with MTX achieved remission (40.5%) compared to patients who received MTX alone (13.5%). The levels of ESR and CRP were lower in patients treated with MTX and doxycycline and this was statistically significant (p = 0.005, p = 0.003 respectively). Conclusion Doxycycline as a cost-effective combination therapy with MTX can achieve higher rates of remission than MTX alone in RA patients without causing increase in the adverse events profile. Trial registration Clinical Trials.gov, NCT03194204. Registered on 21 June 2017

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The Efficacy of Systemic Doxycycline Administration as an Inhibitor of Intimal Hyperplasia after Balloon Angioplasty Arterial Injury

Cited by 4 publications

References 30 publications

Carotid Stent Restenosis and Thrombosis in Rabbits: The Effect of Antiplatelet Agents

Carotid Stent Restenosis and Thrombosis in Rabbits: The Effect of Antiplatelet Agents

A Review on the Relationship between Matrix Metalloproteinases (Mmps) and their Natural Inhibitors (Tissue Inhibitors Of Matrix Metalloproteinases [Timps]) and the Success of an Autologous Arteriovenous Fistula (Avf)

Efficacy of doxycycline as a combination therapy in the treatment of rheumatoid arthritis: a randomized controlled clinical trial

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