The efficacy of the second generation triptan migrepam in the treatment of migraine attacks: results of the comparative study

Tabeeva, G. R.; Evdokimova, E. M.; Shagbazyan, A. E.

doi:10.17116/jnevro201911912120

Cited by 3 publications

(1 citation statement)

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“…As far as the current literature is concerned, ours can be considered as the first study conducted in the ED in which the effectiveness of oral paracetamol and zolmitriptan is compared in the treatment of acute migraine without aura. In accordance with our findings, it can be concluded that oral paracetamol and zolmitriptan might act as effective medications in treating acute migraine without aura, and a large body of research substantiates these results [20][21][22]. Nevertheless, our findings did not reveal the superiority of one drug relative to the other, which parallels findings reported by recent studies [19].…”

Section: Discussionsupporting

confidence: 92%

Oral paracetamol versus zolmitriptan to treat acute migraine attack in the emergency department

2021

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Background: Treatment provided in an emergency department is aimed at alleviating pain immediately with minimized adverse effects as well as warding off further migraine attacks. The primary aim of this article is to compare the effectiveness of oral paracetamol versus zolmitriptan in treating acute migraine attacks. Methods: This prospective, randomized, and controlled study was carried out at a tertiary care hospital visited by 95,000 patients annually. The study recruited 200 participants who were randomized into two groups. One group received 1000 mg paracetamol while the other group received 2.5 mg zolmitriptan orally. Baseline pain scores were recorded using the Visual Analogue Scale (VAS) and Numeric Rating Scale (NRS) at 15, 30 and at 60 min following administration of the study drugs. Patients requiring further treatment were provided fentanyl at a dosage of 1 µg/kg as a rescue therapy. Results: A significant decrease was evident in VAS and NRS scores following the administration of the study drugs in both groups (P < 0.001). The change in VAS pain scores after 15, 30 and 60 min was calculated as 17.0 ± 13.9, 41.2 ± 16.3 and 61.2 ± 17.5 mm, respectively, in the paracetamol group and 14.2 ± 11.7, 39.2 ± 17.9 and 59.2± 19.3 mm, respectively, in the zolmitriptan group, which did not indicate significant differences (P = 0.103, P = 0.425, P = 0.483, respectively). Likewise, NRS pain scores showed a downward trend in line with VAS pain scores and did not yield a significant difference (P = 0.422). No significant difference concerning rescue therapy was noted between the two groups (P = 0.596). Conclusion: Oral paracetamol and zolmitriptan prove to be similarly effective and have low incidence of acute side effects in treating acute migraine cases without aura.

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Section: Discussionsupporting

confidence: 92%

Oral paracetamol versus zolmitriptan to treat acute migraine attack in the emergency department

2021

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The pharmacoeconomic efficacy of lurasidone in the treatment of schizophrenia

Zyryanov

Dyakov

Juperin

et al. 2020

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Comorbidity of asthenic syndrome and primary headaches in students of a medical university

Akhmedova,

Mirzaeva,

Zuev

2024

Vrach

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Headache is one of the most frequent complaints in asthenic syndrome. The article presents the results of a study involving students of a medical university, the purpose of which was to assess the incidence of headaches and identify the main provoking factors of this condition. Adaptogens of plant origin are considered as a means of supportive therapy of asthenic syndrome. The prospects of domestic preparation of adaptogenic action in the prevention and overcoming of asthenic conditions are evaluated.

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The efficacy of the second generation triptan migrepam in the treatment of migraine attacks: results of the comparative study

Cited by 3 publications

References 10 publications

Oral paracetamol versus zolmitriptan to treat acute migraine attack in the emergency department

Oral paracetamol versus zolmitriptan to treat acute migraine attack in the emergency department

The pharmacoeconomic efficacy of lurasidone in the treatment of schizophrenia

Comorbidity of asthenic syndrome and primary headaches in students of a medical university

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