The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus

Shetty, Rahul; Burde, Krishna; Guttal, Kruthika S

doi:10.7860/jcdr/2016/15934.7101

Cited by 11 publications

(39 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results showed a significant reduction in soreness (up to 4 hours post‐application) and size of lesions. Similar results were seen in Shetty et al's study, where the authors found a significant reduction in the VAS scores, degree of erythema, and size of the lesions in the HA group compared to the placebo group. Both results are similar to those of the present study, indicating that 0.2% HA could be a potential treatment option for OLP.…”

Section: Discussionsupporting

confidence: 87%

“…It is an ideal biomaterial for cosmetic, medical, and pharmaceutical applications due to its versatile properties, such as its biocompatibility, non‐immunogenicity, biodegradability, and viscoelasticity. Evidence from measuring the size of the erosive/ulcerated area suggests that there are benefits from using 0.2% HA in promoting healing . Both clinical and animal studies have confirmed the effect of HA on tissue healing.…”

Section: Discussionmentioning

confidence: 96%

“…The potential of topical HA to promote the healing process is confirmed by the healing of leg ulcers and the nasal mucosa after surgery . It has also been shown to reduce the incidence of high‐grade radioepithelitis in patients who have undergone head and neck radiotherapy or breast or pelvic carcinomas . In dentistry, HA has been used for the acceleration of the healing process in tooth sockets, the treatment of temporomandibular joint osteoarthritis, maintaining space in non‐grafted sinus lifting, the management of soreness of recurrent aphthous ulceration (RAU), as monotherapy, or as an adjunct to non‐surgical and/or surgical periodontal treatment to reduce inflammation and promote wound healing…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Topical hyaluronic acid in the management of oral lichen planus: A comparative study

Hashem

Issrani

Elsayed

et al. 2018

J of Invest & Clin Dent

View full text Add to dashboard Cite

Lichen planus is a chronic mucocutaneous inflammatory disorder that is estimated to affect 0.5%-2.2% of the general population. 1 The cause is unknown in most cases; however, in a minority of patients, precipitating factors have been suggested, including dental materials, drugs, stress, and infectious agents. 2 It primarily affects middleaged adults, and the prevalence is greater among women. There are four forms of oral lichen planus (OLP) that relate to clinical appearance: reticular, atrophic, bullous, and erosive. 3 Symptoms arising from OLP vary markedly and often relate to the specific category.Patients with an atrophic/erosive form of OLP often present with symptoms ranging from burning sensation to severe pain, interfering with speaking, eating, and swallowing. 4Patients with symptomatic OLP often require therapy and should be treated if symptoms are significant. 5 Various treatments have Abstract Aim: Oral lichen planus (OLP) is a chronic mucocutaneous disorder seen in clinical dental practice. Despite the progress in research and advances in knowledge, the successful management of OLP is still difficult to achieve. The aim of the present study was to compare the therapeutic effects of triamcinolone (TA) preparation (0.1%) with hyaluronic acid (HA) preparation (0.2%) in the management of OLP. Methods:In total, 40 patients of any age or sex who had symptomatic OLP were selected and randomly divided into two groups. Group I received topical 0.1% TA, and group II received topical 0.2% HA preparation three times per day for a period of 4 weeks. Basement data were recorded for each patient. Patients were evaluated on days 14 and 21, and after completing the course of treatment. The visual analog scale (VAS) was used for evaluating pain and burning sensation, along with an evaluation of the degree of erythema and mean area of the lesion. Data were analyzed by SPSS 17.0 software using Mann-Whitney and t test. P ≤ 0.05 was considered statistically significant. Results:Our results showed considerable improvement in all of the parameters evaluated. Baseline characteristics, including pain score, size, and clinical characteristics of the lesions, were not different between the two treatment groups. Both TA and HA were found to reduce the VAS score, the degree of erythema, and size of the lesions after treatment. Conclusion:The application of HA is suggested, and is an effective substitute for TA in the treatment of OLP. K E Y W O R D Scorticosteroid, hyaluronic acid, mucocutaneous, oral lichen planus, triamcinolonePatients were asked to return to the clinic for review at 14, 21, and 28 days' post-baseline. During these visits, any changes in the VAS values and site of lesion, color, size, or appearance of the lesions were duly noted on the proforma. The entire data were then entered into the proforma. | Statistical analysisAll data were tabulated and analyzed using SPSS version 17.0 (Chicago, IL, USA). The results are presented as mean ± standard deviation. Comparison between the groups for VAS and degree of erythe...

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Topical hyaluronic acid in the management of oral lichen planus: A comparative study

Hashem

Issrani

Elsayed

et al. 2018

J of Invest & Clin Dent

View full text Add to dashboard Cite

show abstract

“…However, both placebo and HA had no effect on the extent and severity of the OLP as described by Thongprasom's criteria for clinical healing score. Similarly in 2016 Shetty et al (24) have reported reduction in VAS scores and a significant improvement in relief of symptoms in the HA treated OLP patients as compared to placebo. Statistically significant improvements were observed in the objective criteria which involved the degree of erythema and the mean area of the lesions with HA application when compared to the control group on placebo.…”

Section: Discussionmentioning

confidence: 82%

The Effect of Topically Applied Hyaluronic Acid Gel Versus Topical Corticosteroid in the Treatment of Erosive Oral Lichen Planus

Youssef

Darwish

Fahmy

et al. 2019

Alexandria Dental Journal

View full text Add to dashboard Cite

INTRODUCTION: Oral lichen planus is a common chronic inflammatory muco-cutaneous disease. Although the cause of oral lichen planus is not well known, T-lymphocyte infiltrate suggests a cell mediated immunological damage to basal cell layer of the epithelium. Its suggested treatment is topical corticosteroid. A promising new treatment for oral lichen planus [OLP] is the topical application of hyaluronic acid [HA], which has shown beneficial effect on wound healing. OBJECTIVES: to evaluate the effect of hyaluronic acid gel in the treatment of erosive oral lichen planus in comparison with topically applied corticosteroids. MATERIALS AND METHODS: a randomized, parallel, controlled clinical study was conducted on twenty patients who were randomly divided into two groups. Group I received topical application of corticosteroid (triamcinolone acetonide) 4-5 daily, for 28 days and Group II was similarly treated using hyaluronic acid 0.2% gel. Subjective symptom and Visual Analogue Scale (VAS) were recorded at base line, after 10 days and at 3 months. The objective sign clinical score was recorded at baseline, 1 and 3 months post-treatment. RESULTS: Both groups showed decrease in the lesion size and symptoms of OLP. The HA treated group showed a significantly higher decrease in the pain score in comparison to the corticosteroid treated group. Regarding the healing score, the corticosteroid group showed superior results than that shown with the HA. CONCLUSIONS: HA 0.2% gel is effective in the treatment of OLP, it resulted in a decrease in symptoms and signs of the disease. HA resulted in more control of pain when compared to topical corticosteroid.

show abstract

“…Therapeutic interventions could also be monitored by the determination of various biomarkers possibly related to the pathogenesis of OLP. The pro-inflammatory cytokine interleukin-6 (IL-6) is thought to be of major pathobiological importance in OLP; therefore, it was shown that salivary IL-6 might represent a useful diagnostic and therapeutic biomarker in OLP [28]. Calprotectin, a protein released during inflammatory conditions by activated polymorphonuclear leukocytes, monocytes, and macrophages, was shown to be increased in the saliva of OLP patients, and might be also used as a monitoring marker [29,30].…”

Section: Introductionmentioning

confidence: 99%

Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study

Bruckmann

Seemann²,

Rappersberger

et al. 2020

Applied Sciences

View full text Add to dashboard Cite

Hyaluronic acid (HA) has anti-inflammatory and anti-edematous effects and, thus, could be promising in the treatment of oral lichen planus (OLP). The aim of the study was to evaluate the effects of topical hyaluronic acid, compared to placebo, on salivary levels of calprotectin, interleukin-6 (IL-6), and bacteria, as well as clinical and subjective parameters. Fourteen patients with confirmed OLP were included. After random selection, patients started with either 0.2% hyaluronic acid or a placebo gel for 6 weeks. Following a wash-out period, the groups changed the application. Whole saliva, clinical parameters, and questionnaires were evaluated before and after the intervention, as well as after the crossover phase. Salivary calprotectin, IL-6, and inflammation-related bacteria were determined by ELISA and PCR, respectively. There were no significant differences in clinical or subjective outcome parameters, salivary levels of IL-6, calprotectin, or bacteria after the application of hyaluronic acid, compared to placebo. However, only nine patients completed the study, as five out of seven patients starting with placebo were lost to follow-up. Significant effects of HA on inflammatory mediators and clinical parameters in OLP patients could not be proven, although a trend in clinical severity improvement could be observed.

show abstract

The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus

Abstract: Topical application of 0.2% Hyaluronic acid showed a significant clinical response when compared to topical placebo. It is easy to use; hence a frequent application scheme should be advised to improve the efficacy of hyaluronic acid.

Cited by 11 publications

References 18 publications

Topical hyaluronic acid in the management of oral lichen planus: A comparative study

Topical hyaluronic acid in the management of oral lichen planus: A comparative study

The Effect of Topically Applied Hyaluronic Acid Gel Versus Topical Corticosteroid in the Treatment of Erosive Oral Lichen Planus

Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study

Contact Info

Product

Resources

About