The efficacy of topical hyaluronic acid in the management of oral lichen planus

Abstract

Topical HA (0.2%) does appear to be of some benefit in the management of erosive lichen planus providing efficacy for up to 4 h after administration. Very frequent applications should be considered to obtain a more significant clinical benefit. Topical HA gel may be a useful addition to the treatment option for OLP.

Medical Management of Oral Lichen Planus: A Systematic Review

“…There was no evidence of difference in mean pain score after treatment between active intervention & placebo in three trials [18,19,30]. A statistically significant reduction in mean pain score favouring the active intervention was seen in the remaining nine trials [3,17,21,[24][25][26]32,33,37].…”

“…Twelve trials compared an active intervention with placebo: cyclosporine [3], clobetasol & miconazole [19], curcuminoids as an adjunct to prednisone [18], pimecrolimus [17,24,33], aloe vera [21,30], hyaluronic acid [26], ignatia [25], lycopene [32] & MuGard [37]. There was no evidence of difference in mean pain score after treatment between active intervention & placebo in three trials [18,19,30].…”

“…Other treatments included: aloe vera in three trials [21,30,31], hyaluronic acid [26], curcuminoids as adjunctive treatment to prednisone [18], Bacillus Calmette-Guerin polysaccharide nucleic acid [28], topical retinoic acid [6], topical thalidomide [29], lycopene [32], topical isotretinoin [12], ignatia [25] & MuGard [37].…”

The Use of Hyaluronic Acid Hydrogels for Tissue Regeneration in Oral Surgery: A Review

“…The researchers indicated that HA might be a successful agent to decrease symptoms of oral lichen planus and provide healing more quickly in erosive lesions. According to the results of the trials of Nolan et al 22,23 , HA may be useful in erosive mucosal and gingival lesions due to its barrier function. Also its bacteriostatic affect might be pro-moted this positive results in the trials of Nolan et al Koray et al 24 , have compared the use of HA and benzydamin hydrochloride sprays after impacted third molar surgery.…”

“…Authors implied that HA showed the barrier function due to the viscoelastic structure and because of the anti-inflammatory properties, HA may be used as a successful therapeutic agent in the treatment of recurrent aphthous ulcers. Either a similar randomized double-blind study was carried out by Nolan et al 23 to…”