The efficacy of tranexamic acid in hip hemiarthroplasty surgery: An observational cohort study

Major Complications and Transfusion Rates After Hemiarthroplasty and Total Hip Arthroplasty for Femoral Neck Fractures

“…Other trials have further shown similar short-term overall complication rates but significantly better functional outcome scores in patients randomized to THA compared to HA [32,33]. Our results showing high transfusion rates in patients after a femoral neck fracture are consistent with those previously published in the literature [16][17][18][19][20]. Complications related to blood transfusions include hematogenic infections (human immunodeficiency virus, hepatitis) and transfusion-related immunomodulation, which has been associated with increased local and general infection rates [34][35][36].…”

“…Although meta-analysis studies of randomized controlled studies have shown no difference in 1-year mortality between HA and THA [6,14,15], there is lack of information regarding perioperative major life-threatening complications. These complications often result in longer hospital stay, prolonged disability, and increased utilization of health care resources.Blood transfusion requirements after hip fractures have been reported to range between 19% and 69% [16][17][18][19][20]. Blomfeldt et al [21] noted significantly greater intraoperative blood loss after THA compared to HA for femoral neck fractures in the elderly.…”

“…Blood transfusion requirements after hip fractures have been reported to range between 19% and 69% [16][17][18][19][20]. Blomfeldt et al [21] noted significantly greater intraoperative blood loss after THA compared to HA for femoral neck fractures in the elderly.…”

A systematic review of tranexamic acid in hip fracture surgery

“…There was a wide variation in the frequency and dose of TXA given peri‐operatively. Of the seven studies, three did not differentiate fracture type or management; two studies examined patients undergoing intracapsular hip fracture treatment (hemi‐arthroplasty) alone and two studies focused on extracapsular hip fractures (one utilized sliding hip screw fixation , the other a short intramedullary nail device ).…”

“…Scientific rationale and supporting evidence suggests that TXA may be useful in reducing blood loss and transfusion rates in hip fracture surgery. Studies into TXA and hip fracture surgery have so far provided variable assessments of efficacy in reducing blood loss and thromboembolic risk with no clear consensus . This topic has yet to be investigated in the form of a systematic review.…”