The efficacy of two dosage regimens of omeprazole, amoxicillin and metronidazole for cure of Helicobacter pylori infection: The hera study

7‐Day Triple Therapy of Helicobacter pylori Infection with Levofloxacin, Amoxicillin, and High‐Dose Esomeprazole in Patients with Known Antimicrobial Sensitivity

“…It appears that in vitro metronidazole resistance may in part be overcome in vivo by quadruple therapy of longer duration (14 days) involving a higher dose of metronidazole [6,32]. A higher cure rate has also been reported for 1600 mg of metronidazole used in combination with amoxicillin – a regimen known as English triple therapy [33]. Another rescue treatment currently used in Germany and other European countries [4,34,35] is dual therapy with high‐dose omeprazole (120 mg daily) and amoxicillin (2.25–3 g), which was developed in the mid‐1990s [36].…”