The efficacy of Ultra-High Frequency Ultrasonography in the diagnosis of intraoral lesions

Izzetti, Rossana; Vitali, Saverio; Aringhieri, Giacomo; Caramella, Davide; Nisi, Marco; Oranges, Teresa; Dini, Valentina; Graziani, Filippo; Gabriele, Mario

doi:10.1016/j.oooo.2019.09.012

Cited by 29 publications

(40 citation statements)

References 24 publications

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“…21 Previous studies have reported that the boundaries of T 1 N 0 M 0 oral lesions may not be clearly discerned from the surrounding healthy tissue using US alone, unless combined with Doppler imaging or high-frequency US imaging. [22][23][24] Ultimately the combination of US with surface fluorescence imaging may provide a better metric for estimating the lesion size than either modality alone.…”

Section: Protoporphyrin IX Fluorescence Imaging Of Oral Lesionsmentioning

confidence: 99%

Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer

et al. 2020

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Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer," J. AbstractSignificance: India has one of the highest rates of oral cancer incidence in the world, accounting for 30% of reported cancers. In rural areas, a lack of adequate medical infrastructure contributes to unchecked disease progression and dismal mortality rates. Photodynamic therapy (PDT) has emerged as an effective modality with potential for treating early stage disease in resourcelimited settings, while photosensitizer fluorescence can be leveraged for treatment guidance.Aim: Our aim was to assess the capability of a simple smartphone-based device for imaging 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence for treatment guidance and monitoring as part of an ongoing clinical study evaluating low-cost technology for ALA-based PDT treatment of early oral cancer.Approach: A total of 29 subjects with <2 cm diameter moderately/well-differentiated microinvasive (< 5 mm depth) oral squamous cell carcinoma lesions (33 lesions total, mean area ∼1.23 cm 2 ) were administered 60 mg∕kg ALA in oral solution and imaged before and after delivery of 100 J∕cm 2 total light dose to the lesion surface. Smartphone-based fluorescence and white light (WL) images were analyzed and compared with ultrasound (US) imaging of the same lesions.Results: We present a comparative analysis of pre-and post-treatment fluorescence, WL, and US images of oral lesions. There was no significant difference in the distribution of lesion widths measured by fluorescence and US (mean widths of 14.5 and 15.3 mm, respectively) and linear regression shows good agreement (R 2 ¼ 0.91). In general, PpIX fluorescence images obtained prior to therapeutic light delivery are able to resolve lesion margins while dramatic photobleaching (∼42%) is visible post-treatment. Segmentation of the photobleached area confirms the boundaries of the irradiated zone. Conclusions:A simple smartphone-based approach for imaging oral lesions is shown to agree in most cases with US, suggesting that this approach may be a useful tool to aid in PDT treatment guidance and monitoring photobleaching as part of a low-cost platform for intraoral PDT.

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Section: Protoporphyrin IX Fluorescence Imaging Of Oral Lesionsmentioning

confidence: 99%

Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer

et al. 2020

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“…4,5 In particular, intraoral use has been widely applied for the evaluation of both normal anatomy and several oral lesions. [6][7][8][9][10] In particular, previous literature described the applicability of UHFUS to the study of salivary glands. 4,11,12 In this proof-of-concept study, we aimed at exploring the usefulness of UHFUS for obtaining valuable labial salivary gland samples for the assessment of the histopathological features of SS patients, thus optimizing the information obtained by a relatively invasive procedure.…”

Section: Introductionmentioning

confidence: 99%

Ultra‐high frequency ultrasonography (UHFUS)‐guided minor salivary gland biopsy: A promising procedure to optimize labial salivary gland biopsy in Sjögren’s syndrome

Izzetti

Ferro

Vitali

et al. 2021

J Oral Pathology Medicine

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Background: Sjögren's syndrome (SS) is an autoimmune disease characterized by an inflammatory infiltrate of exocrine salivary and lachrymal glands. Diagnosis is complex, and minor salivary gland biopsy and subsequent focus score (FS) calculation appear of extreme importance in the diagnostic work-up of the disease. Ultra-high frequency ultrasonography (UHFUS) is a recently introduced diagnostic technique, which is gaining an increasingly important role in intraoral imaging. This study aims at exploring the usefulness of UHFUS for obtaining valuable labial salivary gland samples to assess the histopathological features of SS patients. Methods:Patients with clinical suspect of SS and eligible for minor salivary gland biopsy were enrolled. UHFUS scan of the lower lip was performed. Glandular echostructure was classified according to Outcome Measures in Rheumatology (OMERACT) scoring system. The glands to be sampled were selected on the basis of UHFUS evaluation and biopsied. The areas of the samples were recorded and compared with those obtained without UHFUS guidance. The correlation between UHFUS grade and labial gland FS was also assessed. Results:The areas of the samples obtained with UHFUS guidance were significantly higher (7.25 ± 3.98 mm 2 ) than those obtained by conventional procedures (5.79 ± 3.49 mm 2 , P = .02). UHFUS correlated significantly with the salivary gland FS (r = .532, P = .001). Conclusion:UHFUS seems a promising tool in SS diagnostic algorithm, being able to provide a valuable support to the biopsy procedure. Further studies are mandatory to confirm the role of UHFUS in SS.

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“…In the literature, some attempts to apply UHFUS to the study of ulcerative diseases have been reported with encouraging results. 32,34,44-46 For example, UHFUS allows to correctly stage and diagnose patients affected by hidradenitis suppurativa, and to decide the therapeutic approach. 32 In particular, a potential role in the monitoring following medical treatment and in the presurgical mapping appear feasible.…”

Section: Insights Into a Role For Uhfus In Wound Assessmentmentioning

confidence: 99%

“…34 Interestingly, UHFUS has also been reported to be an effective diagnostic tool also in cases of mucocutaneous diseases involving the oral mucosa. 44-46 From this perspective, such an evaluation appears of great importance as it can provide a quantitative information on the lesion’s echogenicity, thus allowing to better differentiate normal and affected tissue. It is also worth mentioning the effectiveness of texture analysis that can provide the retrieval of information on gray-scale distribution in a selected region of interest.…”

Section: Insights Into a Role For Uhfus In Wound Assessmentmentioning

confidence: 99%

The Application of Ultra-High-Frequency Ultrasound in Dermatology and Wound Management

Izzetti

Oranges

Janowska

et al. 2020

The International Journal of Lower Extremity Wounds

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The management of lower extremity wounds is frequently performed by means of clinical examination, representing a challenge for the clinician due to the various conditions that can potentially enter differential diagnosis. Several diagnostic techniques are available in the dermatologist’s arsenal as a support to diagnosis confirmation, including dermoscopy and ultrasonography. Recently, a novel ultrasonographic technique involving the use of ultra-high ultrasound frequencies has entered the scene, and appears a promising tool in the diagnostic workup of skin ulcerative lesions. The focus of this review is to discuss the potential role of ultra-high-frequency ultrasonography in the diagnostic workup of wounds in the light of the current applications of the technique.

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The efficacy of Ultra-High Frequency Ultrasonography in the diagnosis of intraoral lesions

Cited by 29 publications

References 24 publications

Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer

Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer

Ultra‐high frequency ultrasonography (UHFUS)‐guided minor salivary gland biopsy: A promising procedure to optimize labial salivary gland biopsy in Sjögren’s syndrome

The Application of Ultra-High-Frequency Ultrasound in Dermatology and Wound Management

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