The Efficacy of Varied Oral Steroid Doses on the Treatment of Sudden Sensorineural Hearing Loss

Liu, Chenlin; Ho, Kuen‐Yao; Wang, Ling‐Feng; Chien, Chen‐Yu; Wang, Hsun-Mo

doi:10.5152/iao.2014.26

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Afterwards, to study the synergistic effect of CL extract with Prednisolone, the effect of Prednisolone was studied and results showed the inhibition of cell proliferation, a decline in viability of Nalm-6 cells in relation to dosage (0.5 to 100 ) and time (24 and 48 hours), and the lack of effect of prednisolone on REH cells ( Figure 1C-D). To study the synergistic effect, the 1 µM of Prednisolone was used, since it was lower than the maximum clinical dose and it was used in other studies (1,19,20). Examinations of the synergistic effect revealed that CL extract amplified the effect of prednisolone on inhibition of cell proliferation and the decrease in viability of Nalm-6 cells in combination with Prednisolone, but no synergistic effect was observed in REH cells (Figure 1E-F).…”

Section: Resultsmentioning

confidence: 99%

Analysis of Cytotoxic Activity and Synergistic Effect of Curcuma Longa Extract in Combination with Prednisolone on Acute Lymphoblastic Leukemia Cell Lines

et al. 2017

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Background: Curcuma Longa (CL) extract is a natural compound derived from the roots of Curcuma Longa. Prednisolone is a synthetic glucocorticoid and one of the most important pharmaceutical agents used for treatment of acute lymphoblastic leukemia. Methods: We investigated the cytotoxic effect of Curcuma Longa extract and the synergistic effect of Curcuma Longa extract in combination with Prednisolone on acute lymphoblastic leukemia Nalm-6 and REH cell lines. Results:The obtained results of this research revealed that CL extract led to the death of Nalm-6 and REH cells, while Prednisolone demonstrated cytotoxic effects solely on the Nalm-6 cells. In addition, after combining CL extract and Prednisolone, the synergistic effect was observed only on Nalm-6 cells. The outcome of treatment on normal MDBK cells was the viability of most of the cells. CL extract induced apoptosis and increased expression of the Bax gene and caspase-3 activity. It also reduced Bcl-2 gene expression in Nalm-6 cells, and the aforementioned effects were amplified in the presence of prednisolone. In REH cells, CL extract induced apoptosis and increased Bax gene expression and caspase-3 activity. It also reduced expression of the Bcl-2 gene. Conclusions: In general, our findings suggest that CL extract has cytotoxic effects on acute lymphoblastic leukemia cells and it also amplifies the cytotoxic effect of prednisolone on Nalm-6 cells.

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Section: Resultsmentioning

confidence: 99%

Analysis of Cytotoxic Activity and Synergistic Effect of Curcuma Longa Extract in Combination with Prednisolone on Acute Lymphoblastic Leukemia Cell Lines

et al. 2017

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A Retrospective Study of the Clinical Characteristics and Post-Treatment Hearing Outcome in Idiopathic Sudden Sensorineural Hearing Loss

Ganesan¹,

Kothandaraman²,

Swapna

et al. 2017

Audiology Research

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The purpose of this retrospective study was to analyze the clinical characteristics and document hearing recovery in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). 122 patients diagnosed with unilateral ISSNHL, from March 2009 to December 2014, were treated with oral steroids and pentoxifylline. Hearing change was evaluated by comparing pre-treatment and post-treatment pure-tone average (PTA) (500, 1K, and 2K Hz), and categorized into complete, partial, and no recovery of hearing. T-test, Wilcoxon Signed Rank test and Regression analysis were employed to analyze the statistical significance. Of the 122 patients, seventy-one (58%) had complete recovery and 34 (28%) had partial recovery. The average pre-treatment PTA was 78.3±16.9 dB whereas post-treatment average was 47.0±20.8 dB, showing statistically significant improvement (t=24.89, P≤0.001). The factors such as presence of tinnitus (P=0.005) and initial milder hearing loss (P=0.005) were found to be significant predictors for hearing recovery. Conventional steroid regimes produced a recovery rate in ISSNHL, which exceeds the spontaneous recovery rate. The current study results highlight the importance of medical treatment in the management of ISSNHL.

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The Efficacy of Varied Oral Steroid Doses on the Treatment of Sudden Sensorineural Hearing Loss

Cited by 2 publications

References 20 publications

Analysis of Cytotoxic Activity and Synergistic Effect of Curcuma Longa Extract in Combination with Prednisolone on Acute Lymphoblastic Leukemia Cell Lines

Analysis of Cytotoxic Activity and Synergistic Effect of Curcuma Longa Extract in Combination with Prednisolone on Acute Lymphoblastic Leukemia Cell Lines

A Retrospective Study of the Clinical Characteristics and Post-Treatment Hearing Outcome in Idiopathic Sudden Sensorineural Hearing Loss

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