The efficacy of wax solvents:<i>in vitro</i>studies and a clinical trial

Jg, Fraser

doi:10.1017/s0022215100072856

Cited by 25 publications

(27 citation statements)

References 4 publications

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“…These trials fell into three categories: studies undertaken in primary care (14 studies [41][42][43][44][45][46][47][48][49][50][51][52][53][54] ), studies undertaken in secondary care (eight studies 4,[54][55][56][57][58][59][60] ), and studies of self-care or those undertaken in other care settings (four studies [61][62][63][64] ). Where the setting was in emergency care this has been grouped under primary care in the present review because it was assumed that this was the first point of contact with a health professional.…”

Section: Quantity and Quality Of Research Availablementioning

confidence: 99%

“…In some studies the overall population sample size was not reported, rather the numbers of ears were presented. 42,43,60 Seventeen studies were two-arm comparisons, [41][42][43][44][45][48][49][50][51][52][53][54]56,58,59,63,64 five were three-arm studies, 46,47,55,57,62 and there was one study each with four, 4 five 61 and six 60 intervention arms.…”

Section: Quantity and Quality Of Research Availablementioning

confidence: 99%

“…Care is recommended when interpreting the outcomes of these studies, as it is unclear whether valid statistical analyses (where reported) will have been undertaken (see Cochrane Handbook for Systematic Reviews of Interventions for discussion of appropriate analyses of these types of data 65 ). Finally, there was a wide range in the publication dates of the included studies , and eleven studies were undertaken more than 20 years ago, 41,43,48,50,51,54,57,[59][60][61]64 which may affect the generalisability of the studies to current practice (and account for some of the other issues already raised above). It is likely in current practice that an irrigator rather than a metal syringe will be used for the removal of earwax; however, syringes were used for many of the included studies, although this may not always be clear because 'syringing' and 'irrigation' may sometimes be used interchangeably.…”

Section: Chaptermentioning

confidence: 99%

“…Of the seven RCTs, none of the studies was assessed as having an adequate generation of the randomisation sequence. In one RCT the generation of the randomisation schedule was judged to be partially met, 56 in three this was judged to be inadequate, 57,58,60 and in the remainder it was not possible to judge due to a lack of information. 4,55,59 Only one RCT adequately met the criteria for concealment of allocation.…”

Section: Studies In Secondary Care Settingsmentioning

confidence: 99%

“…One study, 60 that assessed the use of a softening agent and irrigation over a delayed period of time in an unknown population, was included. This study compared sodium bicarbonate, olive oil, Cerumol, Waxsol, TP and dioctyl with a same participant control (of no treatment in one ear) over a 3-day period.…”

Section: Mixed or Unknown Populationsmentioning

confidence: 99%

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The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation

Clegg

Loveman²,

Gospodarevskaya³

et al. 2010

Health Technol Assess

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address. Paying by credit cardYou can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume. How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects...

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Section: Quantity and Quality Of Research Availablementioning

confidence: 99%

Section: Quantity and Quality Of Research Availablementioning

confidence: 99%

Section: Chaptermentioning

confidence: 99%

Section: Studies In Secondary Care Settingsmentioning

confidence: 99%

Section: Mixed or Unknown Populationsmentioning

confidence: 99%

See 3 more Smart Citations

The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation

Clegg

Loveman²,

Gospodarevskaya³

et al. 2010

Health Technol Assess

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Ear drops for the removal of ear wax

Burton¹,

Doree²

2003

The Cochrane Database of Systematic Reviews

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Evidence of any efficacy of vitamin B12 in improving the cognitive function of people with dementia and low serum B12 levels is insufficient. The two trials of acceptable methodology (Fourniere 1997; Seal 2002) were restricted to a small number of patients with Alzheimer's disease and other types of cognitive impairment. No trials involving people without dementia or using other definitions of vitamin B12 deficiency were found.

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Ear drops for the removal of ear wax

Burton

Dorée

2009

Cochrane Database of Systematic Reviews

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Trials have been heterogeneous and generally of low or moderate quality, making it difficult to offer any definitive recommendations on the effectiveness of cerumenolytics for the removal of symptomatic ear wax. Using drops of any sort appears to be better than no treatment, but it is uncertain if one type of drop is any better than another. Future trials should be of high methodological quality, have large sample sizes, and compare both oil-based and water-based solvents with placebo, no treatment or both.

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The efficacy of wax solvents:in vitrostudies and a clinical trial

Cited by 25 publications

References 4 publications

The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation

The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation

Ear drops for the removal of ear wax

Ear drops for the removal of ear wax

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