The Efficiency and Dose of Bovine Purified Protein Derivative Tuberculin

Francis, John; Seiler, R. J.; Frost, A.J.

doi:10.1111/j.1751-0813.1978.tb00279.x

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…This is in agreement with the findings of Thoen and coworkers (210) with respect to ELISA reactions in bison experimentally infected with M. bovis using the same homologous antigens. Our results are also in concordance with the findings of several investigators (11,70) with respect to cross-reactivity in ELISA reactions using either M. bovis antigen to test sera of cattle experimentally inoculated with M. avium or M.A.I.S antigens to test sera obtained from cattle naturally infected with M. bovis. However, this does not comply with the findings of Pier and coworkers (167) who found that a nocardial antigen did not produce cross-precipitation with the sera of cattle infected with Mycobacterium spp..…”

Section: Discussionsupporting

confidence: 92%

“…The sensitivities and specificities of O.T and PPD tuberculin used in single caudal fold or in single cervical test as reported by Francis and coworkers (70,71) are presented in Table 6.…”

Section: Tuberculin Skin Testmentioning

confidence: 99%

“…Average sensitivities and specificities of various tuberculins used in the single caudal fold or single cervical intradermal tests for detection of tuberculosis in cattle(70,71) …”

mentioning

confidence: 99%

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Mycobacterium bovis infection in cattle in Morocco: preparation and evaluation of chemical extracts for use in detection of immune responses

Berrada

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for his support, constant encouragement, guidance and invaluable advice throughout the course of this study. My gratitude to and admiration for him are beyond expression. Particular thanks are due to Pr. D.W. Johnson who introduced me to this exciting field of research. He has been an invaluable source of support, advice, encouragement and practical help. I would like to thank Dr. N.F. Cheville, (National Animal Diseases Center, Ames, la.). Dr.

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Section: Discussionsupporting

confidence: 92%

“…The sensitivities and specificities of O.T and PPD tuberculin used in single caudal fold or in single cervical test as reported by Francis and coworkers (70,71) are presented in Table 6.…”

Section: Tuberculin Skin Testmentioning

confidence: 99%

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Mycobacterium bovis infection in cattle in Morocco: preparation and evaluation of chemical extracts for use in detection of immune responses

Berrada

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Leukocyte Adherence Inhibition Testing in Domestic Animals

Jennings¹

1982

Assessment of Immune Status by the Leukocyte Adherence Inhibition Test

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Advances in ante-mortem diagnosis of tuberculosis in cattle

Buddle¹,

Livingstone²,

Lisle

2009

New Zealand Veterinary Journal

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The tuberculin skin test is effective in the early detection of pre-clinical cases of Mycobacterium bovis infection in cattle. This allows the rapid removal of infected animals, thus limiting transmission of the disease, and has resulted in the eradication of bovine tuberculosis (Tb) from many countries. This test is very likely to remain the primary screening test for M. bovis infection in cattle as it is a simple, robust and inexpensive test. However, a number of ancillary tests are being used, or are currently being validated. These ancillary tests are likely to provide a more accurate diagnosis following skin-testing. The blood-based BOVIGAM interferon-gamma (IFN-gamma) test is a cellular immune assay which can detect early infection, and has become the main ancillary test in New Zealand. It can be used for re-testing skin test-positive animals, to improve specificity and minimise wastage from slaughtering animals with false-positive tests. Alternatively, it can be used in locations of increased risk of infection in parallel with skin-testing, for examining skin test-negative animals for pre-movement testing or in problem herds to identify M. bovis-infected animals that do not respond to the skin test. Several modifications of the test are now being used to improve specificity by altering the cut-off or using specific antigens present in virulent mycobacteria such as the 6 kDa early secreted antigenic target (ESAT-6) and 10 kDa culture filtrate protein (CFP-10). While antibody based tests generally lack sensitivity, as high levels of antibodies tend to occur late in the disease process, they may have unique desirable properties such as the ability to be used as a cow-side test. The use of these new ancillary tests in association with skin-testing will improve the detection of M. bovis-infected cattle and reduce the unnecessary slaughter of false-positive reactors.

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The Efficiency and Dose of Bovine Purified Protein Derivative Tuberculin

Cited by 4 publications

References 10 publications

Mycobacterium bovis infection in cattle in Morocco: preparation and evaluation of chemical extracts for use in detection of immune responses

Mycobacterium bovis infection in cattle in Morocco: preparation and evaluation of chemical extracts for use in detection of immune responses

Leukocyte Adherence Inhibition Testing in Domestic Animals

Advances in ante-mortem diagnosis of tuberculosis in cattle

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