The efficiency of human umbilical cord mesenchymal stem cells as a salvage treatment for steroid-refractory acute graft-versus-host disease

Ding, Yihan; Liu, Chang; Cai, Yiming; Chao-zhen, Hou; Chen, Guanghua; Xu, Yang; Hu, Shaoyan; Wu, Depei

doi:10.1007/s10238-022-00983-1

Cited by 4 publications

(7 citation statements)

References 44 publications

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“…These studies employed bone marrow as the source of MSC. Nevertheless, the use of the umbilical cord as a source seems to be associated with similar results [34].…”

Section: Introductionmentioning

confidence: 70%

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Umbilical Cord Mesenchymal Stromal Cells for Steroid-Refractory Acute Graft-versus-Host Disease

et al. 2023

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Background: Steroid-refractory acute graft-vs.-host disease (SR-aGVHD) is a complication of allogeneic hematopoietic stem cell transplantation with a dismal prognosis and for which there is no consensus-based second-line therapy. Ruxolitinib is not easily accessible in many countries. A possible therapy is the administration of mesenchymal stromal cells (MSCs). Methods: In this retrospective study, 52 patients with severe SR-aGVHD were treated with MSCs from umbilical cord (UC-MSCs) in nine institutions. Results: The median (range) age was 12.5 (0.3–65) years and the mean ± SD dose (×106/kg) was 4.73 ± 1.3 per infusion (median of four infusions). Overall (OR) and complete response (CR) rates on day 28 were 63.5% and 36.6%, respectively. Children (n = 35) had better OR (71.5% vs. 47.1%, p = 0.12), CR (48.6% vs. 11.8%, p = 0.03), overall survival (p = 0.0006), and relapse-free survival (p = 0.0014) than adults (n = 17). Acute adverse events (all of them mild or moderate) were detected in 32.7% of patients, with no significant difference in children and adult groups (p = 1.0). Conclusions: UC-MSCs are a feasible alternative therapy for SR-aGVHD, especially in children. The safety profile is favorable.

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“…These studies employed bone marrow as the source of MSC. Nevertheless, the use of the umbilical cord as a source seems to be associated with similar results [34].…”

Section: Introductionmentioning

confidence: 70%

“…These studies employed bone marrow as the source of MSC. Nevertheless, the use of the umbilical cord as a source seems to be associated with similar results [34]. MSC administration has been associated with a few adverse events, usually of mild presentation [29,30,33].…”

Section: Patients' Characteristics Infused Cell Dose and Schedulementioning

confidence: 94%

Umbilical Cord Mesenchymal Stromal Cells for Steroid-Refractory Acute Graft-versus-Host Disease

et al. 2023

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“…94 An array of studies has demonstrated that the transplantation of hUCB-MSCs can address a spectrum of diseases. [95][96][97] Transplantation of hUCB-MSCs onto the dorsal surface of C57BL mice significantly ameliorated Dex-induced hair loss. 98 Enhanced autophagy in the HFs of the transplanted mice suggested a link between Dex-induced HF damage and decreased autophagy.…”

Section: Dovepressmentioning

confidence: 97%

Autophagy Dysfunction: The Kernel of Hair Loss?

Jin,

Song

2024

CCID

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Autophagy is recognized as a crucial regulatory process, instrumental in the removal of senescent, dysfunctional, and damaged cells. Within the autophagic process, lysosomal digestion plays a critical role in the elimination of impaired organelles, thus preserving fundamental cellular metabolic functions and various biological processes. Mitophagy, a targeted autophagic process that specifically focuses on mitochondria, is essential for sustaining cellular health and energy balance. Therefore, a deep comprehension of the operational mechanisms and implications of autophagy and mitophagy is vital for disease prevention and treatment. In this context, we examine the role of autophagy and mitophagy during hair follicle cycles, closely scrutinizing their potential association with hair loss. We also conduct a thorough review of the regulatory mechanisms behind autophagy and mitophagy, highlighting their interaction with hair follicle stem cells and dermal papilla cells. In conclusion, we investigate the potential of manipulating autophagy and mitophagy pathways to develop innovative therapeutic strategies for hair loss.

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“…Esses estudos empregaram a medula óssea como fonte de CMEs. No entanto, a utilização do cordão umbilical como fonte parece estar associada a resultados semelhantes (DING et al, 2023).…”

Section: Células Mesenquimais Estromaisunclassified

“…Somente os pacientes que sobreviveram além do dia 100 do TCPH (44 pacientes, 84,6%) foram avaliados para a ocorrência da DECH crônica, que foi observada em 10 (22,7%) dos pacientes, dos quais 7/34 (20,6%) crianças e 3/10 (30%) adultos (p= 0,67). Aproximadamente, um terço dos nossos pacientes apresentou EA agudo, em sua maioria de leve intensidade (graus 1 e 2, de acordo com o CTCAE); no entanto, esta foi uma taxa maior do que a observada por outros (KURTZBERG et al, 2020a;DING et al, 2023;LALU et al, 2012;THOMPSON et al, 2020) ZEISER et al, 2020).…”

Section: Dech Crônicaunclassified

Células mesenquimais de cordão umbilical em doença enxerto-contra hospedeiro aguda corticorrefratária

Donadel

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The efficiency of human umbilical cord mesenchymal stem cells as a salvage treatment for steroid-refractory acute graft-versus-host disease

Cited by 4 publications

References 44 publications

Umbilical Cord Mesenchymal Stromal Cells for Steroid-Refractory Acute Graft-versus-Host Disease

Umbilical Cord Mesenchymal Stromal Cells for Steroid-Refractory Acute Graft-versus-Host Disease

Autophagy Dysfunction: The Kernel of Hair Loss?

Células mesenquimais de cordão umbilical em doença enxerto-contra hospedeiro aguda corticorrefratária

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