The Efficiency of Intravenous Theophylline on the Headache Which Occurs After Spinal Anesthesia

Akdere,

doi:10.4021/jnr71e

Cited by 1 publication

(4 citation statements)

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“…It has been reported that the use of theophylline for PDPH should be repeated in different studies. In one study, it was reported that 6 patients (35.3%) with a VAS value of <50% needed a second theophylline infusion and in the other study, 5 (25%) of 20 patients required second theophylline infusion (12,23) . In our study, 22 (33.8%) patients received more than one infusion.…”

Section: Discussionmentioning

confidence: 98%

“…There were 6 studies evaluating theophylline activity in PDPH in our literature search (12,13,23,24) . Theophylline was administered intravenously in 4 of these studies and orally in 2 of them.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, satisfaction of the patients were evaluated with the "patient global impression of change" (PGIC) scale and more than 50% of the patients described themselves as being healed or very healed (13) . In another study, Akdere et al (23) compared theophylline with combination of paracetamol-caffeine and placebo in the treatment of PDPH. They stated that other medication group did not detect a significant change and in theophylline group, pre-, and post-treatment mean VAS scores were 7±2.15 and 2.2±2.04 points, respectively (23) .…”

Section: Discussionmentioning

confidence: 99%

“…In another study, Akdere et al (23) compared theophylline with combination of paracetamol-caffeine and placebo in the treatment of PDPH. They stated that other medication group did not detect a significant change and in theophylline group, pre-, and post-treatment mean VAS scores were 7±2.15 and 2.2±2.04 points, respectively (23) . We observed that while standing VAS scores were 6.0±1.6 and 1.8±1.4 points before, and after the infusion, respectively, and we think that theophylline has an important role in the treatment of PDPH.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Theophylline Efficiency in Post-Dural Puncture Headache

Yıldırım¹,

Bakır²,

Atıcı³

2020

jarss

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Objective: In clinical studies, intravenous theophylline has been reported to be effective in the treatment of postdural puncture headache (PDPH), but its efficacy is not clear to some clinicians due to the small number of patients in these studies. This treatment can be used as an intermediate step in the treatment of PDPH, if the efficacy and safety of theophylline is proven. We aimed to evaluate the efficacy and safety of an intravenous (IV) injection of theophylline on PDPH. Methods: Sixty-five PDPH patients who were injected with IV theophylline according to our "Postdural Puncture Headache Algorithm" were evaluated retrospectively. The primary and secondary endpoints were the degree of headache and the patient's overall response to the treatment, respectively. Treatment safety was evaluated based on the occurrence of adverse reactions. Results: Before the initial theophylline administration, the visual analog scale (VAS) score was 6.0±1.6 points. The VAS scores at one hour post-treatment were 1.8±1.4 points. The mean VAS scores of the patients after theophylline infusion decreased significantly compared to before (p=0.001). Hemodynamic changes due to theophylline were not statistically significant (p>0.05). There were no reports of theophylline-related adverse events in the patient records. Conclusion: An iv injection of theophylline is an effective and safe treatment for PDPH. Intravenous theophylline treatment may find a place between the conservative treatment and invasive interventional therapy in step therapy of PDPH.

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Section: Discussionmentioning

confidence: 98%