The efficiency of methods of diagnosing pulmonary tuberculosis: An investigation in a chest clinic in algiers

Larbaoui, D; Chaulet, P; Grosset, T.; Khélif, Abderrahim; Ait-Mesbah, H.

doi:10.1016/0041-3879(70)90006-1

Cited by 5 publications

(2 citation statements)

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“…Larbaoui et al (1970) observed one patient with generalized purpura thought to be due to 4 months of treatment with rifampicin. Doyle et al (1969) have also found a high incidence of sideeffects (twenty-eight of seventy-four patients, including six with fever) when rifampicin was given in high dosage (1800 mg) twice-weekly.…”

Section: Discussionmentioning

confidence: 99%

Potentially serious side-effects of high-dose twice-weekly rifampicin

Poole

Stradling

Worlledge

1971

Postgraduate Medical Journal

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Summary Daily rifampicin in a single dose of 600 mg, combined with other drugs, usually streptomycin and isoniazid, was given to forty-nine patients for 3 months. It was planned to continue for another 15 months with twice-weekly rifampicin 1200 mg plus isoniazid 900 mg, but the high incidence of side effects led to cessation of the intermittent regimen when only two patients had completed 18 months. Though there was no serious problem with daily treatment, eleven patients (22%) were unable to continue rifampicin on the intermittent regimen. In eight (16%) a pyrexial syndrome occurred. In one of these patients there was also temporary renal failure and in another, precipitous thrombocytopenia led to epistaxis and bleeding into the tongue and lips. Symptomless thrombocytopenia developed in two other patients, making three cases (6%) of thrombocytopenia in all. In sixteen (33%) of the forty-nine patients antibodies to rifampicin were detected in the blood. Side-effects occurred in nine (56%) of these, including the three developing thrombocytopenia, but in only two (6%) of the thirty-three patients with no antibodies detected. This association of toxic reactions with antibodies is highly significant (P < 0·001).

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Section: Discussionmentioning

confidence: 99%

Potentially serious side-effects of high-dose twice-weekly rifampicin

Poole

Stradling

Worlledge

1971

Postgraduate Medical Journal

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“…The main strategy recommended for case detection in developing countries, where 95% of tuberculosis cases occur, is sputum smear microscopy among out-patients with prolonged cough who voluntarily attend health facilities. [1][2][3] Most standard laboratory tests [4] and guide lines [5,6] for mycobacteriology laboratories recommend that at least 3 sputum specimens, preferably collected on successive days, be submitted to the laboratory for AFB smear and culture for patients suspected to have tuberculosis. Unfortunately, there has been a paucity of published data analyzing the validity of this recommendation.…”

Section: Introductionmentioning

confidence: 99%

Screening tuberculosis suspects: How many sputum specimens are adequate?

Salehiniya

Hussain²,

Ali

2012

Ann Trop Med Public Health

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Background:The aim of the study was to assess whether the number of sputum samples for screening of tuberculosis suspects could be minimized. Materials and Methods: It was a hospital-based cross-sectional study conducted from December 2006 to May 2008. Chest symptomatic 2810 patients were screened for tuberculosis (TB) by subjecting them to sputum microscopy using 2 sputum samples as well as 3 samples following standard procedure for sputum collection, staining, and AFB identification. Results: First sputum smear alone could detect 91.8% cases while first 2 samples together could detect 96% cases. Maximum no. of cases were diagnosed by only 2 specimen sputum smears, and added diagnostic value of third specimen was small i.e., 4%. Conclusions: Hence, 2 sputum samples as diagnostic criteria for screening of TB suspects is one way of improving the efficient use of scarce resources.

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The mode of detection of cases of respiratory tuberculosis in Stuttgart (Federal Republic Of Germany), 1964 TO 1970

Neumann

1971

Tubercle

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The efficiency of methods of diagnosing pulmonary tuberculosis: An investigation in a chest clinic in algiers

Cited by 5 publications

References 0 publications

Potentially serious side-effects of high-dose twice-weekly rifampicin

Potentially serious side-effects of high-dose twice-weekly rifampicin

Screening tuberculosis suspects: How many sputum specimens are adequate?

The mode of detection of cases of respiratory tuberculosis in Stuttgart (Federal Republic Of Germany), 1964 TO 1970

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