The efficiency of platelet-rich plasma treatment in patients with knee osteoarthritis

Elik, Hüseyin; Doğu, Beril; Yılmaz, Figen; Begoğlu, Feyza Akan; Kuran, Banu

doi:10.3233/bmr-181374

Cited by 56 publications

(80 citation statements)

References 30 publications

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“…PRP was first shown to be more effective in reducing pain than HA injections at six months follow-up in a randomized controlled trial by Sánchez et al [30] in 2012. e same results were confirmed in the same year by Cerza et al [31] in a large randomized controlled trial on 120 patients. In the following years, a recent review [24] and several other trials confirmed these findings [12,14,17,32] showing, besides no increased risk of adverse events, a significant improvement in short-term exceeding what is considered a minimum clinically important difference. However, the literature currently lacks evidence on the potential of PRP for the treatment of knee OA in sport-active patients.…”

Section: Discussionmentioning

confidence: 75%

“…e use of PRP to treat knee OA is being supported by increasing evidence. Its safety and efficacy were proved in randomized controlled trials versus placebo, proving the effects of PRP, with pain reduction and improvement in function and clinical scores at short-term follow-up [12,14,15,[26][27][28][29]. However, in terms of efficacy in addressing OA joints, the evidence about any possible superiority of PRP versus hyaluronic acid (HA) is more controversial.…”

Section: Discussionmentioning

confidence: 99%

“…Intra-articular injective treatments emerged as an alternative minimally invasive option to provide a clinical benefit and delay more sacrificing procedures while avoiding the impact and risks of surgical treatments in these active patients. In the past few years, platelet-rich plasma (PRP) has been proposed for the treatment of knee OA and its use is now supported by increasing evidence [12][13][14][15][16][17]. Its rational lays on its anabolic and anti-inflammatory properties due to growth factors and cytokines released by platelets [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Platelet-Rich Plasma for Sport-Active Patients with Knee Osteoarthritis: Limited Return to Sport

Altamura

Martino

Andriolo

et al. 2020

BioMed Research International

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Objective. To evaluate a cohort of sport-active patients suffering from cartilage degeneration and OA, in terms of clinical outcome and return to sport (RTS) after platelet-rich plasma (PRP) injective treatment. Design. is study included forty-seven sport-active patients ≤50 years old with unilateral symptomatic knee cartilage degeneration or OA. Patients received 3 PRP injections and were prospectively evaluated at baseline and then at 2, 6, 12, and 24 months follow-up by IKDC subjective EQ-VAS, and Tegner scores. Furthermore, patients were asked about their RTS, in terms of return to any sport level or to their activity level before symptoms onset. Results. IKDC subjective score improved significantly at all follow-ups, changing from 59.2 ± 13.6 to 70.6 ± 13 at 12 months and to 76.7 ± 12.5 at 24 months (p < 0.0005). A similar outcome was observed with the EQ-VAS score. Tegner score improved from 3.6 ± 1.4 to 4.8 ± 0.9 at 24 months (p < 0.0005), but only 76.6% of patients returned to some sport activity and 48.9% to the same activity level. A lower presymptoms Tegner score was associated with a higher RTS rate, both at any level (p � 0.024) and at the same presymptoms level (p < 0.0005). Conclusions. Sport-active patients affected by knee OA can benefit from PRP injections, with pain and function improvement over time. However, results are less satisfactory in terms of RTS since only half can achieve the same sport level as before the onset of symptoms. Patients undergoing PRP treatment should be made aware of their low chances to go back to high-impact sport activities.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Platelet-Rich Plasma for Sport-Active Patients with Knee Osteoarthritis: Limited Return to Sport

Altamura

Martino

Andriolo

et al. 2020

BioMed Research International

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“…The superiority of PRP was also established by comparison with normal saline (physiological control), as indicated by early improving WOMAC (the Western Ontario and McMaster Universities Osteoarthritis) scores, and maintained up to six months [153,158,163], but slightly decreased afterward, in agreement with the anti-inflammatory action supposed for PRP [172].…”

Section: Knee Osteoarthritismentioning

confidence: 54%

Platelet Concentrates in Musculoskeletal Medicine

Mariani

Pulsatelli

2020

IJMS

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Platelet concentrates (PCs), mostly represented by platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are autologous biological blood-derived products that may combine plasma/platelet-derived bioactive components, together with fibrin-forming protein able to create a natural three-dimensional scaffold. These types of products are safely used in clinical applications due to the autologous-derived source and the minimally invasive application procedure. In this narrative review, we focus on three main topics concerning the use of platelet concentrate for treating musculoskeletal conditions: (a) the different procedures to prepare PCs, (b) the composition of PCs that is related to the type of methodological procedure adopted and (c) the clinical application in musculoskeletal medicine, efficacy and main limits of the different studies.

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“…These platelets have α-granules that contain a multitude of bioactive proteins and growth factors such as transforming growth factor-β1 (TGF-β1), platelet-derived growth factor (PDGF), and insulinlike growth factor (IGF-1). 86 There are very few clinical trials of this treatment for knee OA and all with marked differences in sample preparation, centrifugation speed, dosage, and frequency of injections. However, PRP has displayed some efficacy in treating pain, function, and morphology of the regenerated tissue in comparison to…”

Section: Regenerative Medicinementioning

confidence: 99%

Nonsurgical Management of Cartilage Defects of the Knee: Who, When, Why, and How?

2020

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The nonoperative practitioner managing individuals with cartilage defects should use a patient-centered, multifaceted approach that aims to individualize treatment to provide optimal benefit. These include addressing modifiable risk factors for disease progression and instituting interventions such as weight loss, nutrition, physical activity, and potentially regenerative medicine strategies. This review will focus on these nonoperative treatment strategies with a focus on when treatments are necessary, who will benefit from these approaches, why they are specifically appropriate, and, finally, how these treatments directly modify the structure of a patient's cartilage and resulting symptoms.

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The efficiency of platelet-rich plasma treatment in patients with knee osteoarthritis

Cited by 56 publications

References 30 publications

Platelet-Rich Plasma for Sport-Active Patients with Knee Osteoarthritis: Limited Return to Sport

Platelet-Rich Plasma for Sport-Active Patients with Knee Osteoarthritis: Limited Return to Sport

Platelet Concentrates in Musculoskeletal Medicine

Nonsurgical Management of Cartilage Defects of the Knee: Who, When, Why, and How?

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