2023
DOI: 10.3390/molecules28093943
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The Efficient Synthesis and Anti-Fatigue Activity Evaluation of Macamides: The Unique Bioactive Compounds in Maca

Abstract: Macamides are a class of amide alkaloids that are only found in maca and are widely considered to be its bioactive marker compounds. More than thirty macamide monomers have been identified in recent years; however, it is difficult to obtain a single macamide monomer from the maca plant because of their similar structures and characteristics. We used the carbodiimide condensation method (CCM) to efficiently synthesize five typical macamides, including N-benzyl-hexadecanamide (NBH), N-benzyl-9Z,12Z,15Z-octadecen… Show more

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Cited by 7 publications
(4 citation statements)
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“…Macamides and macaenes are benzylated alkamides, which are natural compounds often used to identify maca accurately [ 39 , 125 ]. However, macamides are considered unique to maca [ 47 ], whereas macaenes can be found in other plants such as tomatoes and eggplants [ 125 ]. A review of analytical research using liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) for L. meyenii extracts reported three macaenes ( C -18 fatty acid derivatives) and twenty-three macamides (fatty acid amides) [ 19 ].…”
Section: Select Maca Phytochemicalsmentioning
confidence: 99%
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“…Macamides and macaenes are benzylated alkamides, which are natural compounds often used to identify maca accurately [ 39 , 125 ]. However, macamides are considered unique to maca [ 47 ], whereas macaenes can be found in other plants such as tomatoes and eggplants [ 125 ]. A review of analytical research using liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) for L. meyenii extracts reported three macaenes ( C -18 fatty acid derivatives) and twenty-three macamides (fatty acid amides) [ 19 ].…”
Section: Select Maca Phytochemicalsmentioning
confidence: 99%
“…A slightly older study using different analytical methods (UHPLC-ESI-Orbitrap MS and UHPLC-ESI-QqQ MS) on a methanolic extract of maca cited only eleven macaenes [ 104 ]. Macamides are a unique class of maca phytochemicals, with more than thirty compounds identified and explored for their anti-fatigue effects [ 9 , 47 ]. There is a suggestion in the scientific literature that macaene and macamide compounds could be (partly) responsible for the bioactive effects of maca on sexual performance in male animals [ 17 , 126 ].…”
Section: Select Maca Phytochemicalsmentioning
confidence: 99%
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“…Among them, over the past 20 years, there has been a growing interest in and demand for Lepidium meyenii Walp, or maca, due to its health benefits [ 9 ]. Recent studies indicate that maca may improve endurance, help with autism, and have anti-inflammatory and anticancer properties [ 10 , 11 , 12 , 13 ]. Maca’s secondary metabolites provide neuroprotective and cytoprotective benefits [ 14 ] and improve energy metabolism [ 15 ].…”
Section: Introductionmentioning
confidence: 99%