The Eggshell Waste Transformed Green and Efficient Synthesis of K-Ca(OH)<sub>2</sub> Catalyst for Room Temperature Synthesis of Chalcones

Tanpure, Sagar; Ghanwat, Vishvanath B.; Shinde, Bipin; Tanpure, Kiran; Lawande, Shamrao

doi:10.1080/10406638.2020.1776740

Cited by 28 publications

(24 citation statements)

References 40 publications

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“…We employ a fluorescence assay with the solvatochromic chemosensor, benzofuranyl uridine (BFU), which was initially incorporated into 16 RNA structures with variable sequences. [28][29][30][31][32][33][34] The BFU modification is less bulky than other fluorophores, making it possible to modify more sites within compact RNA structures. Using the raw fluorescence data in principal component analysis (PCA), an unbiased statistical method, we were able to classify the five motifs with 100% predictive power and gained insight into the important topological differences that allowed structural differentiation.…”

Section: Introductionmentioning

confidence: 99%

Visualizing RNA Conformational Changes via Pattern Recognition of RNA by Small Molecules

Eubanks¹,

Zhao²,

Thompson³

et al. 2019

J. Am. Chem. Soc.

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Conformational changes in RNA play vital roles in the regulation of many biological systems, yet these changes can be challenging to visualize. Previously, we demonstrated that Pattern Recognition of RNA by Small Molecules (PRRSM) can unbiasedly cluster defined RNA secondary structure motifs utilizing an aminoglycoside receptor library. In this work, we demonstrate the power of this method to visualize changes in folding at the secondary structure level within two distinct riboswitch structures. After labeling at three independent positions on each riboswitch, PRRSM accurately classified all apo and ligand-bound riboswitch structures, including changes in the size of a structural motif, and revealed modification sites that prevented folding and/or led to a mixture of states. These data underscore the utility and robustness of the PRRSM assay for rapid assessment of RNA structural changes and for gaining ready insight into nucleotide positions critical to RNA folding.

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Section: Introductionmentioning

confidence: 99%

Visualizing RNA Conformational Changes via Pattern Recognition of RNA by Small Molecules

Eubanks¹,

Zhao²,

Thompson³

et al. 2019

J. Am. Chem. Soc.

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“…1)]. [1][2][3][4][5][6][7] The structures of these molecules are reminiscent of the natural products colchicine and combretastatin A-4 ( Fig. 1), [8][9][10] which are potent inhibitors of tubulin polymerization.…”

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confidence: 99%

“…Associated with their tubulin-based mechanism of action, these compounds also disrupt tumor-associated vasculature and thus function as vascular disrupting agents (VDAs). 1,3,4,12,13 Solid tumors increasingly require nutrients and oxygen provided by a network of vasculature, which has distinct structural and architectural differences compared with vasculature associated with normal healthy tissue. 14 Tumor-associated vasculature is highly disorganized with abnormal bulges, blind ends and shunts.…”

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confidence: 99%

“…1,[3][4][5][6] The synthesis of compounds 1 and 3 was later reported by other groups utilizing different synthetic approaches to these molecular scaffolds. [16][17][18] Our reported 1,3,7 synthetic routes towards compounds 1 and 2 were quite similar and involved a Wittig reaction followed by Eaton's reagent mediated intramolecular Friedel-Crafts acylation to provide the six-seven fused ring system (Scheme 1). One of the critical steps in the synthesis of compound 1 involved microwave assisted regioselective demethylation of an aromatic methoxy group using an ionic liquid [TMAH][Al 2 Cl 7 ] to generate the corresponding free phenol.…”

mentioning

confidence: 99%

“…While our original synthetic methodology towards dihydronaphthalene analogues involved reactions that initiated from existing fused aromatic-cycloalkane or -alkanone six-membered ring systems, 5,6 we subsequently envisioned the synthesis of dihydronaphthalene analogues 3 and 4 through ring-forming methodology similar to that depicted in Scheme 1 for the related benzosuberene analogues. 3,4 Unfortunately, efforts to coax the requisite Wittig reaction (Scheme 3) to proceed using (2-carboxyethyl)triphenylphosphonium bromide with NaH or KOtBu in various solvents (THF, CH 3 OH, and DMF) mimicking our previous methodology 1 proved unsuccessful. The reaction was typically complicated by the formation of a mixture of various by-products which appeared to result primarily from decomposition of the Wittig salt under basic conditions.…”

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confidence: 99%

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Efficient synthetic methodology for the construction of dihydronaphthalene and benzosuberene molecular frameworks

Mondal

Niu

Pinney

2019

Tetrahedron Letters

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Benzosuberene analogues (1 and 2) and dihydronaphthalene analogues (3 and 4) function as potent inhibitors of tubulin polymerization, demonstrate pronounced cytotoxicity (low nM to pM range) against human cancer cell lines, and are promising vascular disrupting agents (VDAs). As such, these compounds represent lead anticancer agents with potential translatability towards the clinic. Methodology previously established by us (and others) facilitated synthetic access to a variety of structural and functional group modifications necessary to explore structure activity relationship considerations directed towards the development of these (and related) molecules as potential therapeutic agents. During the course of these studies it became apparent that the availability of synthetic methodology to facilitate direct conversion of the phenolic-based compounds to their corresponding aniline congeners would be beneficial. Accordingly, modified synthetic routes toward these target phenols (benzosuberene 1 and dihydronaphthalene 3) were developed in order to improve scalability and overall yield [45-57% (1) and 32% (3)]. Moreover, benzosuberene-based phenolic analogue 1 and separately dihydronaphthalene-based phenolic analogue 3 were successfully converted into their corresponding aniline analogues 2 and 4 in good yield (>60% over three steps) using a palladium catalyzed amination reaction.

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Facing Seawater Splitting Challenges by Regeneration with Ni−Mo−Fe Bifunctional Electrocatalyst for Hydrogen and Oxygen Evolution

et al. 2021

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Hydrogen, produced by water splitting, has been proposed as one of the main green energy vectors of the future if produced from renewable energy sources. However, to substitute fossil fuels, large amounts of pure water are necessary, scarce in many world regions. In this work, we fabricate efficient and earth-abundant electrodes, study the challenges of using real seawater, and propose an electrode regeneration method to face undesired salt deposition. NiÀ MoÀ Fe trimetallic electrocatalyst is deposited on non-expensive graphitic carbon felts both for hydrogen (HER) and oxygen evolution reactions (OER) in seawater and alkaline seawater. Cl À pitting and the chlorine oxidation reaction are suppressed on these substrates and alkalinized electrolyte. Precipitations on the electrodes, mainly CaCO 3 , originating from seawater-dissolved components have been studied, and a simple regeneration technique is proposed to rapidly dissolve undesired deposited CaCO 3 in acidified seawater. Under alkaline conditions, NiÀ MoÀ Fe-based catalyst is found to reconfigure, under cathodic bias, into NiÀ MoÀ Fe alloy with a cubic crystalline structure and Ni : Fe(OH) 2 redeposits whereas, under anodic bias, it is transformed into a follicular Ni: FeOOH structure. High productivities over 300 mA cm À 2 and voltages down to 1.59 V@10 mA cm À 2 for the overall water splitting reaction have been shown, and electrodes are found stable for over 24 h without decay in alkaline seawater conditions and with energy efficiency higher than 61.5 % which makes seawater splitting promising and economically feasible.

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The Eggshell Waste Transformed Green and Efficient Synthesis of K-Ca(OH)₂ Catalyst for Room Temperature Synthesis of Chalcones

Cited by 28 publications

References 40 publications

Visualizing RNA Conformational Changes via Pattern Recognition of RNA by Small Molecules

Visualizing RNA Conformational Changes via Pattern Recognition of RNA by Small Molecules

Efficient synthetic methodology for the construction of dihydronaphthalene and benzosuberene molecular frameworks

Facing Seawater Splitting Challenges by Regeneration with Ni−Mo−Fe Bifunctional Electrocatalyst for Hydrogen and Oxygen Evolution

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The Eggshell Waste Transformed Green and Efficient Synthesis of K-Ca(OH)2 Catalyst for Room Temperature Synthesis of Chalcones

Cited by 28 publications

References 40 publications

Visualizing RNA Conformational Changes via Pattern Recognition of RNA by Small Molecules

Visualizing RNA Conformational Changes via Pattern Recognition of RNA by Small Molecules

Efficient synthetic methodology for the construction of dihydronaphthalene and benzosuberene molecular frameworks

Facing Seawater Splitting Challenges by Regeneration with Ni−Mo−Fe Bifunctional Electrocatalyst for Hydrogen and Oxygen Evolution

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The Eggshell Waste Transformed Green and Efficient Synthesis of K-Ca(OH)₂ Catalyst for Room Temperature Synthesis of Chalcones