Educational scholars continue to emphasize the confirmed value of high-impact course experiences to enhance learning (Kuh, 2008). Kuh reports that impactful experiences designed to develop diversity and global learning often include explorations of "difficult differences" that expose students to " : : : cultures, life experiences, and worldviews different from their own." Although exploration of "difficult differences" is a worthy goal, it can vary in how it is executed and, consequently, vary in strength of impact. Over the past decade, we applied the Scientist-Educator Model (SEM) in Biopsychology, Sensation and Perception, and Class, Race and Ethnicity in Society courses to design and assess high-impact learning experiences. We used SEM to design interventions that would develop Respect for Human Dignity (RFHD) and assessments to evaluate results. We drew from the literature on prejudice reduction to develop interventions, which involved face-to-face (F2F) experiences with "others" who had sensory challenges, brain/spinal cord injuries, or homelessness. SEM was useful because it guided us through systematic, iterative steps focused on improving student learning. This article discusses how we used SEM to make evidence-based decisions about developing/assessing RFHD through high-impact F2F experiences, as well as how these interventions and assessments can be adapted to other courses.