The ELAPSE (Evaluation of Long-Term Clopidogrel Antiplatelet and Systemic Anti-Inflammatory Effects) Study

Abstract

Our pilot study showed no attenuation of clopidogrel's effects on platelet aggregation with long-term administration. However, platelet activation receptor expression increased with time and should be further evaluated.

Changes in Inflammatory Biomarkers in Patients Treated With Ticagrelor or Clopidogrel

“…20 In one study of clopidogrel-native patients undergoing coronary stenting, clopidogrel treatment was associated with stable sCD40L levels at day 1 and at month 1 of treatment, and with significantly lower levels at months 6 and 12. 37 In our study, levels of sCD40L were slightly lower at discharge but similar to baseline at 4 weeks.…”

Long-Term Aspirin and Clopidogrel Response Evaluated by Light Transmission Aggregometry, VerifyNow, and Thrombelastography in Patients Undergoing Percutaneous Coronary Intervention

“…Detailed baseline demographic characteristics of these 26 patients have previously been reported (17 ). Of the 7 patients who stopped prematurely (4 before the 1-month visit, and 3 before the 6-month visit), 2 had contraindications to long-term dual antiplatelet therapy (nosebleed and surgery for colon cancer).…”

“…Consequently, we conducted a prospective study to investigate the longterm effects of aspirin and clopidogrel in CAD patients undergoing percutaneous coronary intervention (PCI). We found no general tendency toward development of CLR or ALR during long-term therapy, as assessed by LTA and VerifyNow methods (17 ). We compare 3 platelet-function tests (LTA, VerifyNow, and TEG assays) to evaluate their agreement in assessing and classifying ALR and CLR during long-term follow-up.…”

Effect of ASA dose doubling versus switching to clopidogrel on plasma inflammatory markers concentration in patients with type 2 diabetes and high platelet reactivity: The AVOCADO study

“…Several previous studies demonstrated anti--inflammatory effect of low doses of ASA and clopidogrel, mainly in patients with CAD [18][19][20][21][22][23][24][25]. The results of subanalysis of Physician's Health Study suggested that cardioprotective effect of ASA correlated with its anti-inflammatory effect [26].…”