The Electrical Potential Difference Across Human Ileostomy Mucosa

Isaacs, Peter; Horth, C. E.; Turnberg, L A

doi:10.1016/s0016-5085(76)80402-7

Cited by 20 publications

(7 citation statements)

References 21 publications

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“…No patient was receiving steroids and none was taking salt or potassium supplements. From their ileostomy and urine outputs they were similar to those patients studied by Gallagher et al (1962), Clarke et al (1967), and Isaacs et al (1976). Critchley et al (1977) (Muldowney et al, 1957).…”

Section: Discussionsupporting

confidence: 65%

“…Aldosterone was measured using a technique described by Isaacs et al (1976) and prolactin by use of a CIS Kit (Eurotope Services). Plasma renin activity was measured using a modification of an angiotensin I trapping method of Poulsen and Jorgensen (1974 Using the isotope dilution principle, measurements of TENa were completed in 13 subjects and of TEK in 12 subjects.…”

Section: Methodsmentioning

confidence: 99%

“…Evidence that the human small intestine shares this ability to respond to such hormones is, however, imperfect and conflicting. Isaacs et al (1976) demonstrated in an earlier study that plasma aldosterone concentrations were low or normal in patients with ileostomies, despite the observation that in these same patients electrical potential differences were raised across their ileal mucosa, and despite the observation of others (Clarke et al, 1967;Hill et al, 1975) that similar patients are usually in a state of mild continuing salt and water depletion.…”

mentioning

confidence: 92%

“…There is evidence to suggest that ileal mucosal function changes after colectomy and 'adapts' to the new situation by enhancing its capacity to absorb sodium. Isaacs et al (1976) have demonstrated, for instance, that patients with ileostomies have an increased potential difference across their ileal mucosa, and it is possible that this reflects enhanced absorption of sodium by the mucosa. Similarly, it is recognised that, after an ileostomy has been formed, the volume of ejecta decreases in the weeks after surgery, suggesting that the ileostomy adapts in some way (LeVeen et al, 1962;Wright et al, 1969).…”

mentioning

confidence: 99%

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Intracellular electrolyte depletion in patients with ileostomies.

Turnberg¹,

Morris²,

Hawker³

et al. 1978

Gut

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SUMMARY Fourteen apparently healthy patients with ileostomies were found to be depleted of total exchangeable sodium and potassium, but had normal serum electrolyte concentrations and normal extracellular fluid and total body water volumes. The low exchangeable sodium and potassiums were thus primarily due to depletion of the intracellular compartment. There was no evidence of renal or intestinal conservation of these ions and plasma aldosterone, renin activity, and prolactin concentrations were normal in most and only moderately raised in a few. This apparent lack of any hormonal compensatory change to the electrolyte depletion may be due to the normality of the extracellular fluid volume and electrolyte concentrations. These patients seem to have adapted to a stable but depleted intracellular sodium and potassium state.

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Section: Discussionsupporting

confidence: 65%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 92%

mentioning

confidence: 99%

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Intracellular electrolyte depletion in patients with ileostomies.

Turnberg¹,

Morris²,

Hawker³

et al. 1978

Gut

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“…Thus, jejunal PD was found to be +0O6 (Turnberg, Fordtran, Carter & Rector, 1970b) and + 2-0 mV (Sachar, Taylor, Saha & Phillips, 1969) and ileal PD was -5 0 and -6-0 mV in two studies (Turnberg, et al, 1970b;Sachar, et at. 1969) but -8 to -16 mV in another (Isaacs, Horth & Turnberg, 1976). When stripped human intestinal mucosa was investigated in vitro, ileal PD was -9 mV (Grady, Madoff, Duhamel & Chalmers, 1967) and -3-3mV (Corbett, Isaacs, Riley & Turnberg, 1977) and jejunal PD was -5-6 mV (Corbett et al 1977).…”

mentioning

confidence: 94%

Human intestinal potential difference: recording method and biophysical implications.

Gustke¹,

McCormick²,

Ruppin³

et al. 1981

The Journal of Physiology

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SUMMARY1. The transmural electrical potential difference (PD) of the intact human small intestine was recorded with close attention to electrical symmetry, shielding from electromagnetic waves and correction for junction potentials.2. The PD.is -12 mV (mucosa-negative) in the fasting jejunum and ileum and does not change during perfusion with isotonic NaCl.3. Absorption of Na and Cl appears to be non-electrogenic and the 'resting' PD is probably generated by active anion secretion of fasting intestinal contents.4. Diffusion potentials during isotonic D-mannitol perfusion indicated higher cation selectivity in the ileum than in the jejunum.5. The calculated contribution of a free-solution path to total paracellular permeability is 55 % in the jejunum but only 15 % in the ileum. 6. No 'streaming' potential was detected during osmotic water flow, suggesting that the cation-selectivity ofthe channels is temporarily inactivated during dilatation of the lateral intercellular space.

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Moran¹

Urinary Stone Disease

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The Electrical Potential Difference Across Human Ileostomy Mucosa

Cited by 20 publications

References 21 publications

Intracellular electrolyte depletion in patients with ileostomies.

Intracellular electrolyte depletion in patients with ileostomies.

Human intestinal potential difference: recording method and biophysical implications.

Associated Systemic Diseases

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