The Electrical Response to Injury: Molecular Mechanisms and Wound Healing

Reid, Brian; Zhao, Min

doi:10.1089/wound.2013.0442

Cited by 141 publications

(102 citation statements)

References 103 publications

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“…Consequently, high amount of voltage and long duration of current time can result in electrothermal damage, and thus prevention of proper wound healing . Another factor is chemical production, as DC voltage application can cause chemical reactions creating disturbances in pH and, therefore, cell and tissue damage . Other issues with EF in wound healing include patients' reporting of skin tingling and irritation in the area exposed to the EF .…”

Section: Discussionmentioning

confidence: 99%

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A Case of Spinal Cord Stimulator Recharging Interruption in Wound Healing

Güngör

Aiyer

2017

Neuromodulation: Technology at the Neural Interface

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Section: Discussionmentioning

confidence: 99%

“…Another factor is chemical production, as DC voltage application can cause chemical reactions creating disturbances in pH and, therefore, cell and tissue damage . Other issues with EF in wound healing include patients' reporting of skin tingling and irritation in the area exposed to the EF .…”

Section: Discussionmentioning

confidence: 99%

A Case of Spinal Cord Stimulator Recharging Interruption in Wound Healing

Güngör

Aiyer

2017

Neuromodulation: Technology at the Neural Interface

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“…Following the subcutaneous implantation of PVA sponges into the mice, they were maintained in an unstimulated state, without electrodes attached, to enable the normal leukocyte infiltration for 3 days after sponge implantation as previously described. [32][33][34] The ES electrodes used in this study were additively printed to integrate the wires for easy placement and precise control of stimulation over different wound regions. The stimulation current range was chosen based on previous studies applying electrical stimulation to wound areas in animal models and patients.…”

Section: Doi: 101002/adbi201900106mentioning

confidence: 99%

A Platform to Study the Effects of Electrical Stimulation on Immune Cell Activation During Wound Healing

et al. 2019

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Acute and chronic wounds are a significant healthcare burden, and technologies for wound management [1][2][3] are highly desired. Since the endogenous electric field at wound sites is a critical driver of the healing process, [4,5] electrical stimulation (ES) of wound sites has been proposed as a means to accelerate the wound healing process and supplement the standard of care. [6][7][8][9] ES is thought to reduce the chances of infection, increase angiogenesis, and accelerate cell migration. The effects of ES on cutaneous wound healing in animal [10] as well

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“…25 Readers are referred to a special issue of the journal Advances in Wound Care where several articles reviewed experimental research conducted using animal models and in vitro cell studies and described cellular and physiological mechanisms by which EST stimulates tissue repair and wound closure. 26,27 In brief, EST has been shown to increase tissue perfusion and oxygenation due to increased local blood supply, reduced venous congestion, and enhanced capillary branching and angiogenesis. EST can also promote inflammation by enhancing white blood cell migration and infiltration into the site of injury (galvanotaxis), increasing the synthesis and release of chemical mediators, and enhancing phagocytosis and natural debridement of foreign and necrotic material.…”

Section: Purpose Of This Studymentioning

confidence: 99%

Electrical stimulation therapy to promote healing of chronic wounds: a review of reviews

Houghton¹

2017

CWCMR

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Purpose:The overall objective of this study is to identify and appraise all of the existing clinical research literature that has evaluated the effect of electrical stimulation therapy (EST) on wound healing outcomes in adults with various types of chronic wounds. Methods: A systematic and comprehensive search of four electronic databases and gray literature was carried out, and references included in related review articles were checked. Prospective and controlled clinical trials, systematic reviews (SRs), and meta-analyses that assessed the effects of EST on wound healing outcomes were described and appraised. A total PRISMA score was assigned for each included SR based on criteria included in the assessment of multiple systematic reviews (AMSTAR) measurement tool. The percentage of available research that was identified in the SR was also calculated. Results: Sixty-two clinical research studies involving 2082 patients with pressure ulcers, venous leg ulcers, diabetic foot wounds, and arterial/ischemic wounds, and ulcers of mixed etiology were located. Thirty-three of the studies with 1370 patients compared wound size reduction after EST to a control group. Eighteen reviews that used a systematic approach to identify, select, and evaluate published studies on this topic have yielded conflicting results. Poorer quality SRs with a low total PRISMA score were more likely to yield negative or inconclusive findings. Most of these low-quality SRs had very vague research questions and included less than 50% of the available literature that was known to exist. Results from 22 well-designed randomized clinical trials and 10 high-quality SRs consistently support that EST can stimulate faster wound size reduction and/or produce a greater number of closed wounds compared to a group of similar patients receiving either standard wound care or sham EST. Conclusion: Pooled results from well-conducted SRs provide strong support for the use of EST on various types of chronic wounds and pressure ulcers in particular.

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The Electrical Response to Injury: Molecular Mechanisms and Wound Healing

Cited by 141 publications

References 103 publications

A Case of Spinal Cord Stimulator Recharging Interruption in Wound Healing

A Case of Spinal Cord Stimulator Recharging Interruption in Wound Healing

A Platform to Study the Effects of Electrical Stimulation on Immune Cell Activation During Wound Healing

Electrical stimulation therapy to promote healing of chronic wounds: a review of reviews

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