The Electrochemical Behavior of Methotrexate upon Binding to the DNA of Different Cell Lines

Abstract

Methotrexate (MTX) is a widely used anticancer agent whose DNA binding properties are well known. Despite its consolidated usage in the therapeutics of cancer, the physicochemical features of MTX binding to healthy and neoplastic DNA are still not fully understood. Therefore, this work showcases the electrochemical study of MTX binding to distinct DNA sequences through voltametric approaches.

Electroanalysis of Oenological Products for Fingerprinting: a Brief Overview

“…Nanomaterials such as carbon nanotubes, graphene, metal nanoparticles, and molecularly imprinted polymers exhibit unique electrochemical properties that can be leveraged to improve the performance of sensors for detecting specific wine components. Nonetheless, all these techniques have been extensively subjected to proof-of-concept through applications in fermented and unfermented consumer goods [45], pharmaceutical [35,[56][57][58], medical [59] and chemical industries, which highlights the benefits of designing recognition surfaces to enhance analytical response. c) Multimodal Sensing and Data Fusion.…”

Electrochemical Readout in Lab-On-Chip Platforms: Overview of State of the Art and Future Perspectives

“…Integrating multiple functions on a single chip enables LoC platforms to perform complex biochemical and chemical analyses, including DNA analysis, protein assays, cell sorting, and chemical reactions [23,24]. By automating and miniaturising these processes, LoC devices streamline workflows, reduce human error, and consume minimal amounts of reagents and samples, making them environmentally friendly [25].…”