2008
DOI: 10.1002/ana.21434
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The electroencephalographic fingerprint of sleep is genetically determined: A twin study

Abstract: Humans have an individual profile of the electroencephalographic power spectra at the 8 to 16 Hz frequency during non-rapid eye movement sleep that is stable over time and resistant to experimental perturbations. We tested the hypothesis that this electroencephalographic "fingerprint" is genetically determined, by recording 40 monozygotic and dizygotic twins during baseline and recovery sleep after prolonged wakefulness. We show a largely greater similarity within monozygotic than dizygotic pairs, resulting in… Show more

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Cited by 252 publications
(202 citation statements)
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“…They recorded baseline and recovery sleep after sleep deprivation in 40 healthy subjects (mean age: 24.6 ± 2.4 years), consisting of 10 pairs of monozygotic (5 male pairs, 5 female pairs) and 10 pairs of dizygotic (5 male is as high as 95.9 % and independent of sleep propensity (De Gennaro et al, 2008). This finding suggests that the sleep EEG qualifies as the most heritable trait known so far, matched only by heritabilities for brain architecture such as the distribution of grey matter in the cerebral cortex (Andretic et al, 2008).…”
Section: Heritability Of Sleep Eegmentioning
confidence: 99%
“…They recorded baseline and recovery sleep after sleep deprivation in 40 healthy subjects (mean age: 24.6 ± 2.4 years), consisting of 10 pairs of monozygotic (5 male pairs, 5 female pairs) and 10 pairs of dizygotic (5 male is as high as 95.9 % and independent of sleep propensity (De Gennaro et al, 2008). This finding suggests that the sleep EEG qualifies as the most heritable trait known so far, matched only by heritabilities for brain architecture such as the distribution of grey matter in the cerebral cortex (Andretic et al, 2008).…”
Section: Heritability Of Sleep Eegmentioning
confidence: 99%
“…Especially alpha/sigma frequencies appear to reflect particularly strong genetic influences. Indeed, heritability in this frequency range may be as high as 96 % [32].…”
Section: Sleep and Waking Eegmentioning
confidence: 99%
“…In fact, the spatial distribution of EEG oscillations in nonREM sleep is highly stable across multiple recordings within the same individual. Thus, sleep EEG topography was proposed to reflect an individual "fingerprint", which is genetically determined [32,47,48].…”
Section: Homeostatic Sleep-wake Regulationmentioning
confidence: 99%
“…From a quantitative genetic viewpoint, twin studies in adults have determined that objectively measured sleep characteristics such as the overall EEG spectral composition of non-REM sleep (Ambrosius et al 2008;De Gennaro et al 2008), the proportion of time spent in sleep stage 2 and slow-wave sleep (stages 3 and 4), and the density of REM (rapid eye movement) sleep (Linkowski et al 1991;Linkowski et al 1989) have a strong genetic component. In addition, studies using selfreport data have estimated that around 30-50% of the variance in subjective sleep quality is accounted for by genetic influence Heath et al 1990;Partinen et al 1983).…”
Section: Introductionmentioning
confidence: 99%