The Electron Radiolysis of Benzene-M-Terphenyl and Perdeuterobenzene-M- Terphenyl Mixtures

Moffat, A.J.

doi:10.2172/4696611

Cited by 19 publications

(47 citation statements)

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“…6) Combined AAs and radiotherapy may optimize tumor control because single-agent objective response rates with AAs are generally 10% or less [16], and a gradual loss of activity may be seen with monotherapy [50 -52]. This finding is consistent with the adaptive ability of tumor cells in using multiple pathways for angiogenic signaling [53]. Tumors can call on these secondary pathways when the primary pathway is inhibited.…”

Section: Rationale For Combining Aas With Radiationmentioning

confidence: 82%

Design of Clinical Trials of Radiation Combined with Antiangiogenic Therapy

Senan

Smit

2007

The Oncologist

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LEARNING OBJECTIVESAfter completing this course, the reader will be able to:1. Discuss the impact of tumor angiogenesis and hypoxia on the outcome of radiation therapy.2. List the classes of antiangiogenic agents that are in clinical development.3. Identify mechanisms by which antiangiogenic therapy can enhance radiation efficacy.Access and take the CME test online and receive 1 AMA PRA Category 1 Credit ™ at CME.TheOncologist.com CME CME ABSTRACT

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Section: Rationale For Combining Aas With Radiationmentioning

confidence: 82%

Design of Clinical Trials of Radiation Combined with Antiangiogenic Therapy

Senan

Smit

2007

The Oncologist

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“…For comparison, McLaughlin & van der Marel (2005) found γ = 2.05 from fits to the full range of the HST data. 7 A value of γ = 1.65 ± 0.08 was also found for the slope of the number density profile for stars brighter than M V = −5 by Moffat, Drissen & Shara (1994). The extension of the power-law out to ∼10 pc makes R136 a good example of clusters with an extended halo -not all young clusters have such a halo, as illustrated 6 These are the original data from Mackey & Gilmore.…”

Section: Combined Radial Profilementioning

confidence: 83%

“…The extension of the power-law out to ∼10 pc makes R136 a good example of clusters with an extended halo -not all young clusters have such a halo, as illustrated 6 These are the original data from Mackey & Gilmore. McLaughlin & van der Marel (2005) by Moffat et al (1994) through a comparison with NGC 3603, which lacks bright stars beyond ∼1 pc. Maíz Apellániz (2001) shows several extragalactic examples of clusters with and without an extended halo.…”

Section: Combined Radial Profilementioning

confidence: 97%

VLT-MAD observations of the core of 30 Doradus

Campbell

Evans

Mackey

et al. 2010

Monthly Notices of the Royal Astronomical Society

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We present H- and Ks-band imaging of three fields at the centre of 30 Doradus in the Large Magellanic Cloud, obtained as part of the Science Demonstration programme with the Multi-conjugate Adaptive optics Demonstrator (MAD) at the Very Large Telescope. Strehl ratios of 15-30% were achieved in the Ks-band, yielding near-infrared images of this dense and complex region at unprecedented angular resolution at these wavelengths. The MAD data are used to construct a near-infrared luminosity profile for R136, the cluster at the core of 30 Dor. Using cluster profiles of the form used by Elson et al., we find the surface brightness can be fit by a relatively shallow power-law function (gamma~1.5-1.7) over the full extent of the MAD data, which extends to a radius of ~40" (~10pc). We do not see compelling evidence for a break in the luminosity profile as seen in optical data in the literature, arguing that cluster asymmetries are the dominant source, although extinction effects and stars from nearby triggered star-formation likely also contribute. These results highlight the need to consider cluster asymmetries and multiple spatial components in interpretation of the luminosity profiles of distant unresolved clusters. We also investigate seven candidate young stellar objects reported by Gruendl & Chu from Spitzer observations, six of which have apparent counterparts in the MAD images. The most interesting of these (GC09: 053839.24-690552.3) appears related to a striking bow-shock--like feature, orientated away from both R136 and the Wolf-Rayet star Brey 75, at distances of 19.5" and 8" (4.7 and 1.9pc in projection), respectively

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“…Observations suggest, however, that internal optical extinction in GEHRs is indeed fairly small. Studies of the stellar population in 30 Doradus (Malamuth & Heap 1994) and in NGC 3603 (Moffat, Drissen, & Shara 1994), for example, demonstrate that the massive stellar component that dominates production of ionizing radiation is relatively concentrated, suggesting that idealization of the nebula as a single Strömgren sphere is unlikely to be grossly in error. Empirical estimates of A V for GEHRs are also rarely more than A V ≈ 1 (Kennicutt 1984).…”

Section: Observable Extinctionmentioning

confidence: 99%

Consequences of Dust in Metal-rich H II Regions

Shields¹,

Kennicutt²

1995

ApJ

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Dust and associated depletion of heavy elements from the gas phase can modify the thermal properties of H II regions from the dust-free case, with significant consequences for the emergent optical spectrum. We present the results of theoretical calculations illustrating the effects of grains on the spectra of giant, extragalactic H II regions, with emphasis on high metallicity systems (Z > ∼ Z ⊙ ). Dust provides a simple explanation for the observational absence of pure Balmer-line spectra that are expected on theoretical grounds for dust-free, chemically enriched nebulae. Grains may also play a role in enhancements of forbidden-line emission observed in H II regions in the enriched nuclei of normal galaxies. In most cases, depletion introduces the strongest perturbations to the optical spectrum. Selective absorption of the ionizing continuum as well as heating by grain photoelectrons are important in some instances, however, and grain heating can be particularly important for enhancing emission in high-ionization lines. Allowing for depletion, the presence of dust is unlikely to introduce large errors in global metallicity indicators, although uncertainties in depletion factors coupled with the sensitivity of infrared cooling to electron density will make accurate calibrations difficult at high Z. The present calculations establish further that previous relative abundance analyses that fail to take into account dust effects in a self-consistent way (grain heating as well as depletion) may overestimate temperature gradients in high-Z nebulae, resulting in errors in relative abundances for different elements.

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The Electron Radiolysis of Benzene-M-Terphenyl and Perdeuterobenzene-M- Terphenyl Mixtures

Cited by 19 publications

References 0 publications

Design of Clinical Trials of Radiation Combined with Antiangiogenic Therapy

Design of Clinical Trials of Radiation Combined with Antiangiogenic Therapy

VLT-MAD observations of the core of 30 Doradus

Consequences of Dust in Metal-rich H II Regions

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