The electrophysiological study of reception from certain internal organs in man

Сиротин, Б. З.

doi:10.1007/bf00787629

Cited by 4 publications

(5 citation statements)

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“…Most understanding of gut sensory innervation comes from studies in a small number of species of animals (mice, rats, guinea pigs, ferrets, cats, rabbits and sheep), although a few studies (including one dating back to the 1960s) have recorded from sensory neurons innervating human gut, in vitro. [11][12][13] To the extent that the sparse data enables conclusions, sensory nerves in human gut seem similar to those in animals.…”

Section: Sensory Innervation Of the Gutmentioning

confidence: 99%

Extrinsic primary afferent signalling in the gut

Brookes

Spencer

Costa

et al. 2013

Nat Rev Gastroenterol Hepatol

246

216

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Visceral sensory neurons activate reflex pathways that control gut function and also give rise to important sensations, such as fullness, bloating, nausea, discomfort, urgency and pain. Sensory neurons are organised into three distinct anatomical pathways to the central nervous system (vagal, thoracolumbar and lumbosacral). Although remarkable progress has been made in characterizing the roles of many ion channels, receptors, and second messengers in visceral sensory neurons, the basic aim of understanding how many classes there are, and how they differ, has proven difficult to achieve. We suggest that there are just five structurally distinct types of sensory endings in the gut wall that account for essentially all of the primary afferent neurons in the three pathways. Each of these five major structural types of endings seems to show distinctive combinations of physiological responses. These types are: 'intraganglionic laminar' endings in myenteric ganglia; 'mucosal' endings located in the subepithelial layer; 'muscular mucosal' afferents, with mechanosensitive endings close to the muscularis mucosae; 'intramuscular' endings, with endings within the smooth muscle layers; and 'vascular' afferents, with sensitive endings primarily on blood vessels. 'Silent' afferents might be a subset of inexcitable 'vascular' afferents, which can be switched on by inflammatory mediators.Extrinsic sensory neurons comprise an attractive focus for targeted therapeutic intervention in a range of gastrointestinal disorders.2

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Section: Sensory Innervation Of the Gutmentioning

confidence: 99%

Extrinsic primary afferent signalling in the gut

Brookes

Spencer

Costa

et al. 2013

Nat Rev Gastroenterol Hepatol

246

216

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“…The speed of response suggests, that the somatic responses to enteral feeds is likely to be neuronal sensory (afferent) signals. The foregut includes the stomach and duodenum and is innervated by the vagal and thoraco-lumbar vagal afferent fibers (derived from the left and right branches of the vagus nerve) ( 2 ). The right branch of the nodose ganglion innervates the duodenum down to the terminal ileum, the third and fourth parts of the duodenum are innervated by fibers running to the left nodose ganglion ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Celiac Plexus Block to Treat Refractory Feed Induced Dystonia in Children with Severe Neurodisability: A Single Center Case Series

Campbell¹,

Rabone²,

Fadilah³

et al. 2021

JPGN Reports

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Objectives: This observational study describes the procedure technique, safety outcomes, and patient responses to celiac plexus blockade (CPB) in children with severe neurodisability with refractory feed intolerance, feed induced pain or feed induced dystonia (FID). Method: A review of the pathophysiological response to feeding in children with significant neurodisability and the effect on the neuroenteric system. A 2-stage CT-guided temporary celiac plexus blockade followed by neurolysis technique is described. We compile a case series of 5 patients with life limiting conditions and significant disability undergoing CPB in a single tertiary pediatric hospital. Results: A total of 10 separate procedures in 5 children were completed. A positive outcome was observed in 3 out of 4 cases of pediatric FID. Two of the three patients on parenteral nutrition had improved feed tolerance postprocedure. All children tolerated the procedure well, no postprocedure complications were documented. Conclusions: In selected cases, children with life-threatening feed induced dystonia or effective intestinal failure can be safely treated with celiac plexus blockade when other therapies have failed.

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“…The technique of recording impulses in mesenteric nerves has been successful for single-unit afferent activity in the cat, where axons are mostly myelinated (Gammon & Bronk, 1935;Gernandt & Zotterman, 1946;Brown & Gray, 1948;Bessou & Perl, 1966). More often an analysis of multi-unit recordings in a variety of species has been made either in vivo (Zamiatina, 1957;Sharma & Nasset, 1962;Andrews & Andrews, 1971;Itina, 1971;Andrews, Andrews & Orbach, 1972;Hardcastle, Hardcastle & Sanford, 1978, 1980 or in vitro (Sirotin, 1961;Clothier, Green, Hardcastle, Hardcastle & Sanford, 1975;Sanford, 1976). Multi-unit records do not determine whether there is selective sensitivity (specificity) of particular enteroreceptors.…”

Section: Introductionmentioning

confidence: 99%

“…More often an analysis of multi-unit recordings in a variety of species has been made either in vivo (Zamiatina, 1957;Sharma & Nasset, 1962;Andrews & Andrews, 1971;Itina, 1971;Andrews, Andrews & Orbach, 1972;Hardcastle, Hardcastle & Sanford, 1978, 1980 or in vitro (Sirotin, 1961;Clothier, Green, Hardcastle, Hardcastle & Sanford, 1975;Sanford, 1976). Multi-unit records do not determine whether there is selective sensitivity (specificity) of particular enteroreceptors.…”

Section: Introductionmentioning

confidence: 99%

Mechanoreceptors of the Rabbit Duodenum

Cottrell¹

1984

Exp Physiol

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SUMMARYA preparation is described which allowed the investigation of single-unit afferent activity in non-myelinated mesenteric nerves in urethane-anaesthetized rabbits. Three classes of mechanoreceptors were isolated and were located in the muscularis externa (n = 17), the serosa (n = 5) and the mesentery (n = 2). Intraluminal perfusion of chemical solutions containing glucose and hypertonic saline caused increased movement in the loop and also excited mechanoreceptors. No specific chemoreceptors were identified. The results demonstrate that duodenal mechanoreceptors with non-myelinated axons in the rabbit are indirectly sensitive to the chemical composition of duodenal chyme.

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The electrophysiological study of reception from certain internal organs in man

Cited by 4 publications

References 0 publications

Extrinsic primary afferent signalling in the gut

Extrinsic primary afferent signalling in the gut

Celiac Plexus Block to Treat Refractory Feed Induced Dystonia in Children with Severe Neurodisability: A Single Center Case Series

Mechanoreceptors of the Rabbit Duodenum

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