The electrostriction, surface potential and capacitance relaxation of bilayer lipid membranes induced by tetracaine

Hianik, Tibor; Fajkus, Martin; Tarus, Bogdan; Frangopol, Petre T.; Markin, Vladislav S.; Landers, Dennis F.

doi:10.1016/s0302-4598(98)00119-6

Cited by 20 publications

(7 citation statements)

References 15 publications

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“…The molecular mechanism of the pharmacological action for various drugs, such as anesthetics, is mediated by membranes [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. The interaction of anesthetic agents with excitable membranes is postulated to affect the specific trans-membrane proteins of the ionic channels by changing their membrane lipid micro-environment and thus, blocking the nerve signal propagation.…”

Section: Introductionmentioning

confidence: 99%

Procaine Effect on Human Erythrocyte Membrane Explored by Atomic Force Microscopy

Zdrenghea¹,

Tomoaia

Pop-Toader³

et al. 2011

CCHTS

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The procaine effect on human erythrocytes was investigated by atomic force microscopy (AFM) at three procaine concentrations, about 5 x 10(-7) M, 5 x 10(-5) M and 5 x 10(-4) M. The changes in surface morphology of erythrocyte membrane bring direct evidence on the procaine effect on the cell membrane at micro- and nanometer scale. AFM images of the control erythrocytes (without procaine) showed a well defined concave (donut) shape of cells. The structure of control erythrocytes membrane is featured by closely packed nanometer size intra-membranous particles. After the incubation of the fresh blood with increasing procaine concentrations, a progressive increase in both concave depth and surface roughness of erythrocyte membrane was observed. The particles (granules) of the membrane surface increased progressively with increasing procaine concentrations. The changes in the surface morphology of erythrocyte membrane can be associated with the enlargement of surface granules, due to the aggregation of membranous particles within the cell surface, and the domain structure formation induced by procaine. A large number of moderate elevations from 25 nm to almost 40 nm in lateral size were found to be rather uniformly distributed on the surface of whole erythrocytes at low and medium procaine concentrations, respectively. At the highest procaine concentration, the granules of about 80 nm to almost 90 nm lateral size were found to form rows rather well separated. These data are in substantial agreement with the published results obtained on membrane models in the presence of procaine.

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Section: Introductionmentioning

confidence: 99%

Procaine Effect on Human Erythrocyte Membrane Explored by Atomic Force Microscopy

Zdrenghea¹,

Tomoaia

Pop-Toader³

et al. 2011

CCHTS

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“…Dielectric Spectroscopy (DS), a non-invasive method used for detecting electrical, structural and dynamical characteristics of material systems, has been applied in the study of membrane systems by a few research groups, including ours [7][8][9][10][11][12] . Under an AC electrical field, the frequency response of a heterogeneous system containing adsorbate and adsorbent varies due to distribution of the adsorbate.…”

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confidence: 99%

Dielectric study on membrane adsorption and release: Relaxation mechanism and diffusion dynamics

Zhao

Han

2008

Sci. China Ser. B-Chem.

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Dielectric monitoring of the adsorption or release process of salicylic acid (SA) by chitosan membrane shows that the dielectric spectra of the chitosan membrane/ SA solution systems change regularly in the adsorption or release process. By analyzing the regularity, a new mechanism for the relaxations is proposed. The concentration polarization layer (CPL) caused by SA adsorption or release is confirmed to be essential for the dielectric relaxations. The changes of the spectra with time are explained by account of the relationship between CPL properties and dielectric strength. Based on this relaxation mechanism, a theoretical method can be established to calculate dynamical parameters of inner structure of the adsorption or release systems from their dielectric spectra. Therefore, dielectric spectroscopy is demonstrated to be a promising method for estimating interfacial distribution of ionic substances and their binding to membrane in a non-invasive way.

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“…The authors also concluded that TTC increases surface potential more effectively than LDC 37 . Furthermore, both the charged and uncharged forms of TTC and LDC induce substantial changes in the membrane dipole potential 38 , 39 .…”

Section: Introductionmentioning

confidence: 99%

Blocking ion channels induced by antifungal lipopeptide syringomycin E with amide-linked local anesthetics

Zakharova

Efimova

Schagina

et al. 2018

Sci Rep

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The effects of the amide-linked (lidocaine (LDC), mepivacaine (MPV), prilocaine (PLC)) and ester-bound local anesthetics (benzocaine (BZC), procaine (PRC), and tetracaine (TTC)) on the pore-forming activity of the antifungal lipopeptide syringomycin E (SRE) in lipid bilayers were studied. Independently on electrolyte concentration in the membrane bathing solution the observed changes in conductance of SRE channels agreed with the altered membrane dipole potential under the action of ester-bound local anesthetics. Effects of aminoamides in diluted and concentrated solutions were completely different. At 0.1 M KCl (pH 7.4) the effects of amide-linked anesthetics were in accordance with changes in the membrane surface potential, while at 2 M KCl aminoamides blocked ion passage through the SRE channels, leading to sharp reductions in pore conductance at negative voltages and 100-fold decreases in the channel lifetimes. The effects were not practically influenced by the membrane lipid composition. The interaction cooperativity implied the existence of specific binding sites for amide-bound anesthetics in SRE channels.

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The electrostriction, surface potential and capacitance relaxation of bilayer lipid membranes induced by tetracaine

Cited by 20 publications

References 15 publications

Procaine Effect on Human Erythrocyte Membrane Explored by Atomic Force Microscopy

Procaine Effect on Human Erythrocyte Membrane Explored by Atomic Force Microscopy

Dielectric study on membrane adsorption and release: Relaxation mechanism and diffusion dynamics

Blocking ion channels induced by antifungal lipopeptide syringomycin E with amide-linked local anesthetics

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