The elusive role of prolactin in the sociality of the naked mole-rat

Gilbert, James D.; Rossiter, Stephen J.; Bennett, Nigel C.; Faulkes, Christopher G.

doi:10.1016/j.yhbeh.2022.105196

Cited by 3 publications

(1 citation statement)

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“…PRL transcript was downregulated in more cooperative males. Prolactin is best known for its role in promoting parental care behaviors, including in cooperative breeders (Schoech et al, 1996), but emerging studies suggest other functions such as inhibiting aggression in cooperative breeders (Gilbert et al, 2022; Medger et al, 2019) and promoting nest defense behavior (Mohamed et al, 2016). The negative relationship observed appears contradictory to the role of prolactin in promoting prosocial behavior, and again, may reflect the origin of these cooperative displays from aggressive interactions (Díaz-Muñoz et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Neurogenomic landscape associated with status-dependent cooperative behavior

Bolton

Ryder

Dakin

et al. 2022

Preprint

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The neurogenomic mechanisms modulating cooperation are largely unknown, and previous work has been largely constrained to considering few genes in limited neurological space. Here we leverage transcriptomic and behavioral data on birds that perform cooperative courtship displays to better understand the mechanisms underlying cooperative behaviors. Males of the neotropical wire-tailed manakin (Pipra filicauda) form cooperative display coalitions, and their cooperative behaviors are modulated by testosterone in a status-specific manner: Testosterone promotes cooperation in non-territorial birds, but suppresses it in territory holders. To understand the neurogenomic basis of individual and status-specific regulation of cooperative display behavior, we profiled gene expression in 10 brain nuclei and two key endocrine tissues known to regulate social behavior. We associated gene expression with each bird's detailed behavioral and endocrine profile derived from years of repeated measures taken from free-living birds in the Ecuadorian Amazon. We found distinct landscapes of constitutive gene expression were associated with social status, testosterone phenotype, and cooperation, reflecting the modular organization and engagement of neuroendocrine tissues. Sex-steroid and neuropeptide signaling appear important in mediating status-specific relationships between testosterone and cooperation, and suggests shared regulatory mechanisms with male aggressive and sexual behaviors. We also find that systemic gene expression across the brain that could form the basis of social status-specific neuro-physical phenotypes, which are potentially mediated by testosterone and growth hormone. Overall, our findings provide new, systems-level insights into the mechanisms of cooperative behavior, and suggest differences in neurogenomic state form the basis for individual differences in behavioral phenotypes.

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Section: Discussionmentioning

confidence: 99%

Neurogenomic landscape associated with status-dependent cooperative behavior

Bolton

Ryder

Dakin

et al. 2022

Preprint

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Introduction to the Special Issue “Hormones and Hierarchies”

Edwards

Holmes

2023

Hormones and Behavior

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Neurogenomic landscape associated with status‐dependent cooperative behaviour

Bolton,

Ryder,

Dakin

et al. 2024

Molecular Ecology

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The neurogenomic mechanisms mediating male–male reproductive cooperative behaviours remain unknown. We leveraged extensive transcriptomic and behavioural data on a neotropical bird species (Pipra filicauda) that performs cooperative courtship displays to understand these mechanisms. In this species, the cooperative display is modulated by testosterone, which promotes cooperation in non‐territorial birds, but suppresses cooperation in territory holders. We sought to understand the neurogenomic underpinnings of three related traits: social status, cooperative display behaviour and testosterone phenotype. To do this, we profiled gene expression in 10 brain nuclei spanning the social decision‐making network (SDMN), and two key endocrine tissues that regulate social behaviour. We associated gene expression with each bird's behavioural and endocrine profile derived from 3 years of repeated measures taken from free‐living birds in the Ecuadorian Amazon. We found distinct landscapes of constitutive gene expression were associated with social status, testosterone phenotype and cooperation, reflecting the modular organization and engagement of neuroendocrine tissues. Sex‐steroid and neuropeptide signalling appeared to be important in mediating status‐specific relationships between testosterone and cooperation, suggesting shared regulatory mechanisms with male aggressive and sexual behaviours. We also identified differentially regulated genes involved in cellular activity and synaptic potentiation, suggesting multiple mechanisms underpin these genomic states. Finally, we identified SDMN‐wide gene expression differences between territorial and floater males that could form the basis of ‘status‐specific’ neurophysiological phenotypes, potentially mediated by testosterone and growth hormone. Overall, our findings provide new, systems‐level insights into the mechanisms of cooperative behaviour and suggest that differences in neurogenomic state are the basis for individual differences in social behaviour.

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The elusive role of prolactin in the sociality of the naked mole-rat

Cited by 3 publications

References 113 publications

Neurogenomic landscape associated with status-dependent cooperative behavior

Neurogenomic landscape associated with status-dependent cooperative behavior

Introduction to the Special Issue “Hormones and Hierarchies”

Neurogenomic landscape associated with status‐dependent cooperative behaviour

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